Cement glands

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Diagram of a male P. lauroi showing the anterior and posterior testes, and eight cement glands in a clustered arrangement. Pachysentis lauroi.png
Diagram of a male P. lauroi showing the anterior and posterior testes, and eight cement glands in a clustered arrangement.

Cement glands are small organs found in Acanthocephala that are used to temporarily close the posterior end of the female after copulation. [1]

Cement glands are also mucus-secreting organs that can attach embryos or larvae to a solid substrate. These can be found in frogs such as those in the genus Xenopus , [2] fish such as the Mexican tetra, [3] and crustaceans.

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Anterior gradient protein 2 homolog (AGR-2), also known as secreted cement gland protein XAG-2 homolog, is a protein that in humans is encoded by the AGR2 gene. Anterior gradient homolog 2 was originally discovered in Xenopus laevis. In Xenopus AGR2 plays a role in cement gland differentiation, but in human cancer cell lines high levels of AGR2 correlate with downregulation of the p53 response, cell migration, and cell transformation. However, there have been other observations that AGR2 can repress growth and proliferation.

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References

  1. Bush, Albert O.; Fernández, Jacqueline C.; Esch, Gerald W.; Seed, J. Richard (2001). Parasitism : the diversity and ecology of animal parasites. Cambridge, UK New York, NY: Cambridge University Press. p. 203. ISBN   0-521-66278-8. OCLC   44131774.
  2. Sive, Hazel; Bradley, Leila (1996). "A sticky problem: The Xenopus cement gland as a paradigm for anteroposterior patterning". Developmental Dynamics. 205 (3): 265–280. doi:10.1002/(SICI)1097-0177(199603)205:3<265::AID-AJA7>3.0.CO;2-G. PMID   8850563. S2CID   22326745 . Retrieved 29 September 2021.
  3. Pottin, Karen; Hyacinthe, Carole; Rétaux, Sylvie (October 5, 2010). "Conservation, development, and function of a cement gland-like structure in the fish Astyanax mexicanus". Proceedings of the National Academy of Sciences. 107 (40): 17256–17261. Bibcode:2010PNAS..10717256P. doi: 10.1073/pnas.1005035107 . PMC   2951400 . PMID   20855623.