Christian Sell | |
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Alma mater | State University of New York at Binghampton |
Known for | aging |
Scientific career | |
Institutions | Drexel University College of Medicine and Albany Medical College |
Website | drexel |
Christian Sell is an American scientist who works as an associate professor in the department of biochemistry and molecular biology at the Drexel University College of Medicine. [1]
Sell attended the State University of New York at Binghampton, and received his bachelor's degree in biology in 1982. He then moved to Albany Medical College, where he received his PhD in pathology in 1990. [1] He then continued his research career as a postdoctoral researcher, first at Temple University and then at Thomas Jefferson University. Finally, he joined the Medical College of Pennsylvania as an assistant professor in 1994. He moved to the Lankenau Institute for Medical Research as an associate investigator in 1998, and since 2005 has been a tenured associate professor at the Drexel University College of Medicine. [1] [2]
From 2017 to 2018 Sell served as president of the American Aging Association, the largest scientific society devoted to the study of the biology of aging in the United States of America. [3] In 2018, he was elected as a Fellow of the Gerontological Society of America. Since 2019, Sell has served as an associate editor of GeroScience, [4] and from 2016 to 2020 he served as Editor-in-chief of Frontiers in Endocrinology; Endocrinology of Aging. [5] [ failed verification ]
Sell's laboratory focuses on the role of the mTOR protein kinase in cellular senescence, and in 2019 his research group showed that the mTOR inhibitor rapamycin can extend the lifespan of human cells and decrease the appearance of aged cells in human skin. [6] [7]
Life extension is the concept of extending the human lifespan, either modestly through improvements in medicine or dramatically by increasing the maximum lifespan beyond its generally-settled limit of 125 years. Several researchers in the area, along with "life extensionists", "immortalists", or "longevists", postulate that future breakthroughs in tissue rejuvenation, stem cells, regenerative medicine, molecular repair, gene therapy, pharmaceuticals, and organ replacement will eventually enable humans to have indefinite lifespans through complete rejuvenation to a healthy youthful condition (agerasia). The ethical ramifications, if life extension becomes a possibility, are debated by bioethicists.
Edward Calvin Kendall was an American chemist. In 1950, Kendall was awarded the Nobel Prize for Physiology or Medicine along with Swiss chemist Tadeusz Reichstein and Mayo Clinic physician Philip S. Hench, for their work with the hormones of the adrenal gland. Kendall did not only focus on the adrenal glands, he was also responsible for the isolation of thyroxine, a hormone of the thyroid gland and worked with the team that crystallized glutathione and identified its chemical structure.
Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumor (PEComa). It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants. It is a mechanistic target of rapamycin kinase (mTOR) inhibitor that inhibits activation of T cells and B cells by reducing their sensitivity to interleukin-2 (IL-2).
The mammalian target of rapamycin (mTOR), also referred to as the mechanistic target of rapamycin, and sometimes called FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene. mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases.
Robert Joseph Lefkowitz is an American physician and biochemist. He is best known for his groundbreaking discoveries that reveal the inner workings of an important family G protein-coupled receptors, for which he was awarded the 2012 Nobel Prize for Chemistry with Brian Kobilka. He is currently an Investigator with the Howard Hughes Medical Institute as well as a James B. Duke Professor of Medicine and Professor of Biochemistry and Chemistry at Duke University.
MAP kinase-activated protein kinase 2 is an enzyme that in humans is encoded by the MAPKAPK2 gene.
Ribosomal protein S6 kinase beta-1 (S6K1), also known as p70S6 kinase, is an enzyme that in humans is encoded by the RPS6KB1 gene. It is a serine/threonine kinase that acts downstream of PIP3 and phosphoinositide-dependent kinase-1 in the PI3 kinase pathway. As the name suggests, its target substrate is the S6 ribosomal protein. Phosphorylation of S6 induces protein synthesis at the ribosome.
Kun-Liang Guan, is a Chinese and American biochemist. He won the MacArthur Award in 1998.
Masayoshi Yamaguchi is a Japanese scientist and researcher in the biomedical fields related to biochemistry, endocrinology, metabolism, nutrition, pharmacology and toxicology.
Manchanahalli Rangaswamy Satyanarayana Rao was an Indian scientist. He was awarded the fourth-highest civilian award, the Padma Shri, for Science and Engineering in 2010. From 2003 to 2013 he was president of Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) in Bangalore, India.
GeroScience is a premier bi-monthly, international, peer-reviewed journal that publishes cutting-edge research related to the biology of aging, pathophysiology of age-related diseases, and research on biomedical applications that impact aging and/or the pathogenesis of diseases associated with old age. GeroScience publishes manuscripts that cover the entire spectrum of geroscience, ranging from basic science, translational and clinical research, to epidemiology and public health interventions, all centered around aging research.
David Gems is a British geneticist who studies the biology and genetics of ageing (biogerontology). He is Professor of Biogerontology at the Research Department of Genetics, Evolution and Environment, University College London and he is a co-founder and Research Director of the UCL Institute of Healthy Ageing. His work concerns understanding the underlying causes of aging. His research laboratory tests theories of aging and develops new ones using a short-lived animal model C. elegans.
David M. Sabatini is an American scientist and a former professor of biology at the Massachusetts Institute of Technology. From 2002 to 2021, he was a member of the Whitehead Institute for Biomedical Research. He was also an investigator of the Howard Hughes Medical Institute from 2008 to 2021 and was elected to the National Academy of Sciences in 2016. He is known for his contributions in the areas of cell signaling and cancer metabolism, most notably the co-discovery of mTOR.
Michael Nip Hall is an American-Swiss molecular biologist and professor at the Biozentrum of the University of Basel, Switzerland. He discovered TOR, a protein central for regulating cell growth.
Henry Jay Forman is both Distinguished Professor Emeritus of Biochemistry at the University of California, Merced. and Research Professor Emeritus of Gerontology at the USC Leonard Davis School of Gerontology. He is a specialist in free radical biology and chemistry, antioxidant defense, and pioneered work in redox signaling including the mechanisms of induced resistance to oxidative stress.
Sandhya Srikant Visweswariah is a scientist and academic at the Indian Institute of Science, Bangalore, India. She is currently the Chairperson of the Department of Molecular Reproduction, Development and Genetics and the Co-chair of the Centre for Biosystems Science and Engineering, Indian Institute of Science. She additionally holds the position of Adjunct Professor, Faculty of Medicine and Dentistry, University of Bergen, Norway. Her research involves the investigation of the mechanism of signal transduction via cyclic nucleotides, phosphodiesterases and novel cyclases in bacteria. Most recently, she was awarded a Bill and Melinda Gates Grand Challenges Explorations Grant for her proposal entitled "A Small Animal Model of ETEC-Mediated Diarrhea".
Joseph Heitman is an American physician-scientist focused on research in genetics, microbiology, and infectious diseases. He is the James B. Duke Professor and Chair of the Department of Molecular Genetics and Microbiology at Duke University School of Medicine.
Senescence-associated secretory phenotype (SASP) is a phenotype associated with senescent cells wherein those cells secrete high levels of inflammatory cytokines, immune modulators, growth factors, and proteases. SASP may also consist of exosomes and ectosomes containing enzymes, microRNA, DNA fragments, chemokines, and other bioactive factors. Soluble urokinase plasminogen activator surface receptor is part of SASP, and has been used to identify senescent cells for senolytic therapy. Initially, SASP is immunosuppressive and profibrotic, but progresses to become proinflammatory and fibrolytic. SASP is the primary cause of the detrimental effects of senescent cells.
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. The hallmarks of aging are the types of biochemical changes that occur in all organisms that experience biological aging and lead to a progressive loss of physiological integrity, impaired function and, eventually, death. They were first listed in a landmark paper in 2013 to conceptualize the essence of biological aging and its underlying mechanisms.
Veronica Galvan is a Professor and the Donald W. Reynolds Endowed Chair of Aging Research in the Department of Biochemistry and Molecular Biology at the University of Oklahoma Health Sciences Center. Since December 2022, she has served as Director of the Oklahoma Nathan Shock Center on Aging. She also serves as co-director of the Center for Geroscience and Healthy Brain Aging at the University of Oklahoma Health Sciences Center.
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