Chung-Kang Peng

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Chung-Kang Peng
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Chung-Kang Peng, 2017
Scientific career
Fields Statistical physics
Institutions Beth Israel Deaconess Medical Center
Harvard Medical School
National Central University
National Chiao Tung University

Chung-Kang Peng is the Director of the Center for Dynamical Biomarkers at Beth Israel Deaconess Medical Center / Harvard Medical School (BIDMC/HMS). [1] Under his direction the Center for Dynamical Biomarkers researches fundamental theories and novel computational algorithms for characterizing physiological states in terms of their dynamical properties. He is also currently the K.-T. Li Visiting Chair Professor at National Central University (NCU), Visiting Chair Professor at National Chiao Tung University (NCTU) in Taiwan, and Visiting Professor at China Academy of Chinese Medical Sciences in China. During 2012–2014, he served as the founding Dean of the College of Health Sciences and Technology at NCU in Taiwan.

Contents

Research

Biomarker development

Peng has extensive expertise in statistical physics and its application to the study of physiological measures. Along with fellow collaborators he has developed many novel techniques in this area, including:

Peng's publications have been cited more than 37,000 times (h-index: 73). [10] He was the recipient of the 10-Years (2002-2012) Innovator Award from BIDMC in 2013, and Distinguished Alumnus Award of NCTU in 2015.[ citation needed ]

Physionet

Peng is one of the founding members of the PhysioNet resource. PhysioNet offers free web access to large collections of recorded physiologic signals and related open-source software. PhysioNet has more than 1 million visitors, and more than 200 TB of data downloaded each year.

Biomedical device development

Jointly with the HTC Corporation, Peng led a team, called Dynamical Biomarkers Group (DBG), of physicians, scientists and engineers to compete in the Qualcomm Tricorder XPRIZE international competition, the biggest biomedical prize in history. Since its announcement in 2012, this XPRIZE attracted the interest of more than 300 teams around the world. The goal of the competition is to develop a mobile solution for end-patients to diagnose their health conditions and monitor their vital signs. The Tricorder name is based on the medical diagnostic device of Star Trek fame. After 4 years of competition and several rounds of eliminations, DBG is one of the top 2 teams that advanced to the final round of competition, and received a $1 million prize for its achievement in April 2017. [11]

Related Research Articles

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Self-organized criticality (SOC) is a property of dynamical systems that have a critical point as an attractor. Their macroscopic behavior thus displays the spatial or temporal scale-invariance characteristic of the critical point of a phase transition, but without the need to tune control parameters to a precise value, because the system, effectively, tunes itself as it evolves towards criticality.

Network theory Study of graphs as a representation of relations between discrete objects

Network theory is the study of graphs as a representation of either symmetric relations or asymmetric relations between discrete objects. In computer science and network science, network theory is a part of graph theory: a network can be defined as a graph in which nodes and/or edges have attributes.

In quantum mechanics, einselections, short for "environment-induced superselection", is a name coined by Wojciech H. Zurek for a process which is claimed to explain the appearance of wavefunction collapse and the emergence of classical descriptions of reality from quantum descriptions. In this approach, classicality is described as an emergent property induced in open quantum systems by their environments. Due to the interaction with the environment, the vast majority of states in the Hilbert space of a quantum open system become highly unstable due to entangling interaction with the environment, which in effect monitors selected observables of the system. After a decoherence time, which for macroscopic objects is typically many orders of magnitude shorter than any other dynamical timescale, a generic quantum state decays into an uncertain state which can be expressed as a mixture of simple pointer states. In this way the environment induces effective superselection rules. Thus, einselection precludes stable existence of pure superpositions of pointer states. These 'pointer states' are stable despite environmental interaction. The einselected states lack coherence, and therefore do not exhibit the quantum behaviours of entanglement and superposition.

Complex network Network with non-trivial topological features

In the context of network theory, a complex network is a graph (network) with non-trivial topological features—features that do not occur in simple networks such as lattices or random graphs but often occur in networks representing real systems. The study of complex networks is a young and active area of scientific research inspired largely by empirical findings of real-world networks such as computer networks, biological networks, technological networks, brain networks, climate networks and social networks.

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The mathematical expressions for thermodynamic entropy in the statistical thermodynamics formulation established by Ludwig Boltzmann and J. Willard Gibbs in the 1870s are similar to the information entropy by Claude Shannon and Ralph Hartley, developed in the 1940s.

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Anomalous diffusion is a diffusion process with a non-linear relationship between the mean squared displacement (MSD), , and time. This behavior is in stark contrast to Brownian motion, the typical diffusion process described by Einstein and Smoluchowski, where the MSD is a linear in time. Examples of anomalous diffusion in nature have been observed in biology in the cell nucleus, plasma membrane and cytoplasm.

Community structure

In the study of complex networks, a network is said to have community structure if the nodes of the network can be easily grouped into sets of nodes such that each set of nodes is densely connected internally. In the particular case of non-overlapping community finding, this implies that the network divides naturally into groups of nodes with dense connections internally and sparser connections between groups. But overlapping communities are also allowed. The more general definition is based on the principle that pairs of nodes are more likely to be connected if they are both members of the same community(ies), and less likely to be connected if they do not share communities. A related but different problem is community search, where the goal is to find a community that a certain vertex belongs to.

In stochastic processes, chaos theory and time series analysis, detrended fluctuation analysis (DFA) is a method for determining the statistical self-affinity of a signal. It is useful for analysing time series that appear to be long-memory processes or 1/f noise.

The percolation threshold is a mathematical concept in percolation theory that describes the formation of long-range connectivity in random systems. Below the threshold a giant connected component does not exist; while above it, there exists a giant component of the order of system size. In engineering and coffee making, percolation represents the flow of fluids through porous media, but in the mathematics and physics worlds it generally refers to simplified lattice models of random systems or networks (graphs), and the nature of the connectivity in them. The percolation threshold is the critical value of the occupation probability p, or more generally a critical surface for a group of parameters p1, p2, ..., such that infinite connectivity (percolation) first occurs.

Surrogate data testing is a statistical proof by contradiction technique and similar to parametric bootstrapping used to detect non-linearity in a time series. The technique basically involves specifying a null hypothesis describing a linear process and then generating several surrogate data sets according to using Monte Carlo methods. A discriminating statistic is then calculated for the original time series and all the surrogate set. If the value of the statistic is significantly different for the original series than for the surrogate set, the null hypothesis is rejected and non-linearity assumed.

In theoretical physics, a dynamical horizon (DH) is a local description of evolving black-hole horizons. In the literature there exist two different mathematical formulations of DHs—the 2+2 formulation developed by Sean Hayward and the 3+1 formulation developed by Abhay Ashtekar and others. It provides a description of a black hole that is evolving. A related formalism, for black holes with zero influx, is an isolated horizon.

Differential dynamic microscopy (DDM) is an optical technique that allows performing light scattering experiments by means of a simple optical microscope. DDM is suitable for typical soft materials such as for instance liquids or gels made of colloids, polymers and liquid crystals but also for biological materials like bacteria and cells.

Sample entropy (SampEn) is a modification of approximate entropy (ApEn), used for assessing the complexity of physiological time-series signals, diagnosing diseased states. SampEn has two advantages over ApEn: data length independence and a relatively trouble-free implementation. Also, there is a small computational difference: In ApEn, the comparison between the template vector and the rest of the vectors also includes comparison with itself. This guarantees that probabilities are never zero. Consequently, it is always possible to take a logarithm of probabilities. Because template comparisons with itself lower ApEn values, the signals are interpreted to be more regular than they actually are. These self-matches are not included in SampEn. However, since SampEn makes direct use of the correlation integrals, it is not a real measure of information but an approximation. The foundations and differences with ApEn, as well as a step-by-step tutorial for its application is available at.

Dynamical decoupling (DD) is an open-loop quantum control technique employed in quantum computing to suppress decoherence by taking advantage of rapid, time-dependent control modulation. In its simplest form, DD is implemented by periodic sequences of instantaneous control pulses, whose net effect is to approximately average the unwanted system-environment coupling to zero. Different schemes exist for designing DD protocols that use realistic bounded-strength control pulses, as well as for achieving high-order error suppression, and for making DD compatible with quantum gates. In spin systems in particular, commonly used protocols for dynamical decoupling include the Carr-Purcell and the Carr-Purcell-Meiboom-Gill schemes. They are based on the Hahn spin echo technique of applying periodic pulses to enable refocusing and hence extend the coherence times of qubits.

Ary Louis Goldberger is a physician-educator, whose collaborative research work is at the interface of biomedicine and complexity science. He holds a BA from Harvard College and an MD from Yale Medical School. He did his clinical training in internal medicine and cardiovascular disease at Yale–New Haven Hospital and at the University of California, San Diego, respectively. He currently serves as Professor of Medicine at Harvard Medical School and was one of the Core Founding Faculty (2010-2015) of the Wyss Institute for Biologically Inspired Engineering at Harvard University.

Quantum machine learning Interdisciplinary research area at the intersection of quantum physics and machine learning

Quantum machine learning is the integration of quantum algorithms within machine learning programs. The most common use of the term refers to machine learning algorithms for the analysis of classical data executed on a quantum computer, i.e. quantum-enhanced machine learning. While machine learning algorithms are used to compute immense quantities of data, quantum machine learning utilizes qubits and quantum operations or specialized quantum systems to improve computational speed and data storage done by algorithms in a program. This includes hybrid methods that involve both classical and quantum processing, where computationally difficult subroutines are outsourced to a quantum device. These routines can be more complex in nature and executed faster on a quantum computer. Furthermore, quantum algorithms can be used to analyze quantum states instead of classical data. Beyond quantum computing, the term "quantum machine learning" is also associated with classical machine learning methods applied to data generated from quantum experiments, such as learning the phase transitions of a quantum system or creating new quantum experiments. Quantum machine learning also extends to a branch of research that explores methodological and structural similarities between certain physical systems and learning systems, in particular neural networks. For example, some mathematical and numerical techniques from quantum physics are applicable to classical deep learning and vice versa. Furthermore, researchers investigate more abstract notions of learning theory with respect to quantum information, sometimes referred to as "quantum learning theory".

Dwight Barkley is a professor of mathematics at the University of Warwick.

In many-body physics, the problem of analytic continuation is that of numerically extracting the spectral density of a Green function given its values on the imaginary axis. It is a necessary post-processing step for calculating dynamical properties of physical systems from quantum Monte Carlo simulations, which often compute Green function values only at imaginary-times or Matsubara frequencies.

References

  1. "Chung-Kang Peng". Rey Labs.
  2. Yang, Albert; Hseu, Shu-Shya; Yien, Huey-Wen; Goldberger, Ary; Peng, C.-K. (March 2003). "Linguistic Analysis of the Human Heartbeat Using Frequency and Rank Order Statistics". Physical Review Letters. 90 (10): 108103. Bibcode:2003PhRvL..90j8103Y. doi:10.1103/PhysRevLett.90.108103. PMID   12689038.
  3. Peng, C.-K; Buldyrev, S. V; Havlin, S; Simons, M; Stanley, H. E; Goldberger, A. L (1994). "Mosaic organization of DNA nucleotides". Physical Review E. 49 (2): 1685. Bibcode:1994PhRvE..49.1685P. doi: 10.1103/PhysRevE.49.1685 . PMID   9961383.
  4. Costa, Madalena; Goldberger, Ary L; Peng, C.-K (2005). "Multiscale entropy analysis of biological signals". Physical Review E. 71 (2): 021906. Bibcode:2005PhRvE..71b1906C. doi:10.1103/PhysRevE.71.021906. PMID   15783351.
  5. Costa, Madalena; Goldberger, Ary L; Peng, C.-K (2002). "Multiscale Entropy Analysis of Complex Physiologic Time Series". Physical Review Letters. 89 (6): 068102. Bibcode:2002PhRvL..89f8102C. CiteSeerX   10.1.1.377.7077 . doi:10.1103/PhysRevLett.89.068102. PMID   12190613.
  6. Yang, Albert; Hseu, Shu-Shya; Yien, Huey-Wen; Goldberger, Ary; Peng, C.-K. (March 2003). "Linguistic Analysis of the Human Heartbeat Using Frequency and Rank Order Statistics". Physical Review Letters. 90 (10): 108103. Bibcode:2003PhRvL..90j8103Y. doi:10.1103/PhysRevLett.90.108103. PMID   12689038.
  7. Yang, ACC; Peng, C-K; Yien, HW; Goldberger, AL (2003). "Information categorization approach to literary authorship disputes". Physica A. 329 (3–4): 473–483. Bibcode:2003PhyA..329..473Y. doi:10.1016/S0378-4371(03)00622-8.
  8. Thomas, Robert Joseph; Mietus, Joseph E; Peng, Chung-Kang; Goldberger, Ary L (2005). "An Electrocardiogram-Based Technique to Assess Cardiopulmonary Coupling During Sleep". Sleep. 28 (9): 1151–61. doi: 10.1093/sleep/28.9.1151 . PMID   16268385.
  9. Hu, Kun; Peng, C.K; Huang, Norden E; Wu, Zhaohua; Lipsitz, Lewis A; Cavallerano, Jerry; Novak, Vera (2008). "Altered phase interactions between spontaneous blood pressure and flow fluctuations in type 2 diabetes mellitus: Nonlinear assessment of cerebral autoregulation". Physica A: Statistical Mechanics and its Applications. 387 (10): 2279–2292. Bibcode:2008PhyA..387.2279H. doi:10.1016/j.physa.2007.11.052. PMC   2329796 . PMID   18432311.
  10. "Chung-Kang Peng". Google Scholar.
  11. "Tricorder teams". X Prize Foundation. Archived from the original on 2017-09-21. Retrieved 2017-09-20.