Related Research Articles
Aplastic anemia (AA) is a severe hematologic condition in which the body fails to make blood cells in sufficient numbers. Blood cells are produced in the bone marrow by stem cells that reside there. Aplastic anemia causes a deficiency of all blood cell types: red blood cells, white blood cells, and platelets.
Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood, in order to replicate inside a patient and produce additional normal blood cells. HSCT may be autologous, syngeneic, or allogeneic.
Graft-versus-host disease (GvHD) is a syndrome, characterized by inflammation in different organs. GvHD is commonly associated with bone marrow transplants and stem cell transplants.
Allotransplant is the transplantation of cells, tissues, or organs to a recipient from a genetically non-identical donor of the same species. The transplant is called an allograft, allogeneic transplant, or homograft. Most human tissue and organ transplants are allografts.
Anthony Nolan is a UK charity that works in the areas of leukaemia and hematopoietic stem cell transplantation. It manages and recruits donors to the Anthony Nolan Register, which is part of an aligned registry that also includes the Welsh Bone Marrow Donor Registry, NHS Blood and Transplant's British Bone Marrow Registry and Deutsche KnochenMarkSpenderdatei (DKMS) UK. This aligned register is known as the Anthony Nolan & NHS Stem Cell Registry. It also carries out research to help make bone marrow transplants more effective.
Canadian Blood Services is a non-profit charitable organization that is independent from the Canadian government. The Canadian Blood Services was established as Canada's blood authority in all provinces and territories except for Quebec in 1998. The federal, provincial and territorial governments created the Canadian Blood Services through a memorandum of understanding. Canadian Blood Services is funded mainly through the provincial and territorial governments.
Cell therapy is a therapy in which viable cells are injected, grafted or implanted into a patient in order to effectuate a medicinal effect, for example, by transplanting T-cells capable of fighting cancer cells via cell-mediated immunity in the course of immunotherapy, or grafting stem cells to regenerate diseased tissues.
Total body irradiation (TBI) is a form of radiotherapy used primarily as part of the preparative regimen for haematopoietic stem cell transplantation. As the name implies, TBI involves irradiation of the entire body, though in modern practice the lungs are often partially shielded to lower the risk of radiation-induced lung injury. Total body irradiation in the setting of bone marrow transplantation serves to destroy or suppress the recipient's immune system, preventing immunologic rejection of transplanted donor bone marrow or blood stem cells. Additionally, high doses of total body irradiation can eradicate residual cancer cells in the transplant recipient, increasing the likelihood that the transplant will be successful.
Transfusion-associated graft-versus-host disease (TA-GvHD) is a rare complication of blood transfusion, in which the immunologically competent donor T lymphocytes mount an immune response against the recipient's lymphoid tissue. These donor lymphocytes engraft, recognize recipient cells as foreign and mount an immune response against recipient tissues. Donor lymphocytes are usually identified as foreign and destroyed by the recipient's immune system. However, in situations where the recipient is severely immunocompromised, or when the donor and recipient HLA type is similar, the recipient's immune system is not able to destroy the donor lymphocytes. This can result in transfusion associated graft-versus-host disease. This is in contrast with organ/tissue transplant associated GvHD, where matching HLA reduces the incident of the complication.
Jay Feinberg is a long-term leukemia survivor, community organizer and founder and current CEO of the Gift of Life Marrow Registry.
The National Marrow Donor Program (NMDP) is a nonprofit organization founded in 1987 and based in Minneapolis, Minnesota, that operates the Be The Match Registry of volunteer hematopoietic cell donors and umbilical cord blood units in the United States.
Treosulfan, sold under the brand name Trecondi, is a medication given to people before they have a bone marrow transplant from a donor known as allogeneic hematopoietic stem cell transplantation. It is used as a 'conditioning' treatment to clear the bone marrow and make room for the transplanted bone marrow cells, which can then produce healthy blood cells. It is used together with another medicine called fludarabine in adults and children from one month of age with blood cancers as well as in adults with other severe disorders requiring a bone marrow transplant.
Transplantable organs and tissues may refer to both organs and tissues that are relatively often transplanted, as well as organs and tissues which are relatively seldom transplanted. In addition to this it may also refer to possible-transplants which are still in the experimental stage.
The Gift of Life Marrow Registry is a non-profit organization founded in 1991 and headquartered in Boca Raton, Florida that operates a public blood stem cell and bone marrow registry while facilitating transplants for children and adults battling life-threatening illnesses, including leukemia, lymphoma, other cancers and genetic diseases.
Bone marrow failure occurs in individuals who produce an insufficient amount of red blood cells, white blood cells or platelets. Red blood cells transport oxygen to be distributed throughout the body's tissue. White blood cells fight off infections that enter the body. Bone marrow progenitor cells known as megakaryocytes produce platelets, which trigger clotting, and thus help stop the blood flow when a wound occurs.
Ayelet Yakira Galena was born with a rare genetic disorder dyskeratosis congenita and was famous for the massive outpouring of support she attracted, including bone marrow drives that led to finding 162 lifesaving matches.
Deutsche Knochenmarkspenderdatei, abbreviated as DKMS, is an international nonprofit bone marrow donor center based in Tübingen, Germany, with entities in Chile, India, Poland, South Africa, the United Kingdom and the United States. DKMS works in the areas of blood cancer and hematopoietic stem cell transplantation and raises awareness of the need for donors for hematopoietic stem cell transplantation which people with blood cancers need for treatment as well as helping people sign up to their national bone marrow registries. Over the years, DKMS has expanded beyond Germany.
The World Transplant Games (WTG) are an international multi-sport event, occurring every two years, organized by the World Transplant Games Federation (WTGF). The Games promote amateur sport amongst organ transplant recipients, living donors and donor families.
Amal Bishara is an Israeli Arab doctor, and the director of Bone Marrow Registry Outreach, Hadassah Medical Center, which is associated with the Hebrew University of Jerusalem in Israel. There she runs the only bone marrow transplant registry in the world for unrelated Arab donors. Dr. Amal has published and presented internationally on her research into immunogenetics. She serves on the Accreditation Committee of the European Federation for Immunogenetics.
Shimon Slavin is an Israeli professor of medicine. He pioneered immunotherapy mediated by allogeneic donor lymphocytes and innovative methods for stem cell transplantation to cure hematological malignancies and solid tumors. He also used hematopoietic stem cells to induce transplantation tolerance to bone marrow and organ allografts.
References
General references
- Saragoza, Ana (2019). "The Kids Are Alright? The Need for Kidfluencer Protections". American University Journal of Gender, Social Policy & the Law . 28 (4): 575–602.
Inline citations
- 1 2 3 "Meet the Clements twins -- the 'most beautiful twins in the world'". Yahoo! Finance . December 24, 2019. Retrieved May 21, 2022.
- ↑ "Most Beautiful Twins in the World. Then & Now". What's Good?. April 13, 2022. Retrieved January 12, 2024.
- 1 2 3 Keating, Caitlin (December 24, 2019). "9-Year-Old Instagram Stars Ask Fans to Help Find Bone Marrow Transplant to Save Their Dad's Life". People . Archived from the original on August 12, 2023. Retrieved August 12, 2023.
- 1 2 Adeaga, Favour; Wangare, Jackline (May 16, 2023). "Meet the most beautiful twins in the world: Ava Marie and Leah Rose Clements". Yen.com.gh. Archived from the original on August 12, 2023. Retrieved August 12, 2023.
- ↑ Clements twins [@clementstwins] (July 7, 2021). "11 today 🎉🎂" . Retrieved June 26, 2022– via Instagram.
- 1 2 "Clements Twins Search on Social Media for Dad's Bone Marrow Donor as He Battles Cancer". Inside Edition . December 11, 2019. Retrieved May 21, 2022.
- ↑ Clements, Jaqi (October 10, 2017). "The CrAzY, FUN, not always easy but at least we have each other... Journey of The Clements Twins". TheClementsTwins.com. Archived from the original on December 31, 2017. Retrieved May 24, 2022.
- ↑ Armstrong, Harriet (June 22, 2018). "'The most beautiful girls in the world' strike again". 9Honey . Retrieved August 12, 2023.