Collen Masimirembwa | |
---|---|
Born | 1967 (age 56–57) |
Nationality | Zimbabwean |
Citizenship | Zimbabwe |
Occupation(s) | President and chief scientific officer of the African Institute of Biomedical Science and Technology |
Known for | Pharmacogenetics, pharmacology, and drug discovery |
Awards | Fellow of the African Academy of Sciences, Fellow of the Zimbabwe Academy of Sciences, HUGO Africa Award |
Collen Masimirembwa (born 1967) is a biomedical pharmacologist from Zimbabwe. He is a Distinguished Professor of Clinical Pharmacology at the University of Witswatersrand, [1] and serves as the president and chief scientific officer at the African Institute of Biomedical Science and Technology (AiBST). His research in Africa has contributed to the field of pharmacogenetics, particularly in understanding the genetic diversity and drug response of African populations. In 2018, he was awarded the HUGO Africa Award. [2] He is a fellow of the Calestous Juma Leadership Fellowship, [3] African Academy of Sciences (AAS) and the Zimbabwe Academy of Sciences (ZAS).
He has authored over 100 papers in peer-reviewed journals and book chapters and has guided numerous postgraduate students and postdoctoral fellows. [4]
Masimirembwa was born in 1967 in Zimbabwe [5] and received his BSc (Hons) and DPhil degrees in biochemistry from the University of Zimbabwe in 1993. [6] Fascinated by the then-emerging field of pharmacogenetics, he conducted studies at the Karolinska Institute in Sweden in 1995, [5] where he earned his PhD in Medical Biochemistry and Biophysics. His doctoral research was centered on the molecular mechanisms of drug metabolism and toxicity. [7] [8]
After obtaining his PhD, Masimirembwa returned to the University of Zimbabwe and served as a senior lecturer and head of the Department of Biochemistry from 1992 to 1997. [6] He later joined AstraZeneca R&D in Sweden as a principal scientist and project leader, focusing on drug discovery and development in various areas such as cardiovascular, gastrointestinal, and infectious diseases. He played a key role in establishing the AstraZeneca Africa Pharmacogenetics Research Network, which aimed to study the genetic diversity and drug response of African populations. [7] [6]
Later in 2008, Masimirembwa founded and assumed the position of president and chief scientific officer at the African Institute of Biomedical Science and Technology (AiBST), a non-profit research institute in Zimbabwe that focuses on biomedical science and technology, with an emphasis on pharmacogenetics and clinical pharmacology. [9]
At the institute, he manages collaborations with various academic, industry, and government partners. He also leads the African Pharmacogenomics Consortium (APC), a network that aims to advance pharmacogenomics research and applications in Africa. [6] He is also a distinguished professor of health sciences research at the University of the Witwatersrand (South Africa). [7] [10]
Masimirembwa is a fellow of the Zimbabwe Academy of Sciences (ZAS) [5] and the African Academy of Sciences (AAS) among many other honors. In November 2021, Masimirembwa was selected as a Calestous Juma Science Leadership Fellow by the Bill and Melinda Gates Foundation, to develop a research and innovation ecosystem, train scientists, and create centres of excellence in genomic medicine research to enhance Africa’s sustainable development in genomic and pharmaceutical capabilities. [11]
Collen Masimirembwa was named a Fellow of the Zimbabwe Academy of Sciences in 2017 and the African Academy of Sciences in 2018. In 2018, he was awarded the HUGO Africa Award. [12] The Grand Challenges Africa Award was presented to him in 2016. He was the recipient of the EDCTP Senior Fellowship Award in 2014 [13] and the Wellcome Trust Senior Fellowship Award in 2012. AstraZeneca R&D acknowledged his work with the Global Scientific Award in 2006 and the Global Innovation Award in 2005. [7] [11] Additionally, he received the Calestous Juma Leadership Fellowship in 2021 [14] and the PMCW 2025 Pioneer Award. [15]
Pharmacology is the science of drugs and medications, including a substance's origin, composition, pharmacokinetics, pharmacodynamics, therapeutic use, and toxicology. More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function. If substances have medicinal properties, they are considered pharmaceuticals.
Omeprazole, sold under the brand names Prilosec and Losec, among others, is a medication used in the treatment of gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger–Ellison syndrome. It is also used to prevent upper gastrointestinal bleeding in people who are at high risk. Omeprazole is a proton-pump inhibitor (PPI) and its effectiveness is similar to that of other PPIs. It can be taken by mouth or by injection into a vein. It is also available in the fixed-dose combination medication omeprazole/sodium bicarbonate as Zegerid and as Konvomep.
Pharmacogenomics, often abbreviated "PGx," is the study of the role of the genome in drug response. Its name reflects its combining of pharmacology and genomics. Pharmacogenomics analyzes how the genetic makeup of a patient affects their response to drugs. It deals with the influence of acquired and inherited genetic variation on drug response, by correlating DNA mutations with pharmacokinetic, pharmacodynamic, and/or immunogenic endpoints.
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Cytochrome P450 2C19 is an enzyme protein. It is a member of the CYP2C subfamily of the cytochrome P450 mixed-function oxidase system. This subfamily includes enzymes that catalyze metabolism of xenobiotics, including some proton pump inhibitors and antiepileptic drugs. In humans, it is the CYP2C19 gene that encodes the CYP2C19 protein. CYP2C19 is a liver enzyme that acts on at least 10% of drugs in current clinical use, most notably the antiplatelet treatment clopidogrel (Plavix), drugs that treat pain associated with ulcers, such as omeprazole, antiseizure drugs such as mephenytoin, the antimalarial proguanil, and the anxiolytic diazepam.
The International Union of Basic and Clinical Pharmacology (IUPHAR) is a voluntary, non-profit association representing the interests of scientists in pharmacology-related fields to facilitate Better Medicines through Global Education and Research around the world.
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