Crichton-Browne sign

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Crichton-Browne sign is a clinical sign in which there is twitching of the outer margins of the eyes and mouth. It is an early sign of general paralysis of the insane.

A medical sign is an objective indication of some medical fact or characteristic that may be detected by a patient or anyone, especially a physician, before or during a physical examination of a patient. For example, whereas a tingling paresthesia is a symptom, erythema is a sign. Symptoms and signs are often nonspecific, but often combinations of them are at least suggestive of certain diagnoses, helping to narrow down what may be wrong. In other cases they are specific even to the point of being pathognomonic.

General paresis, also known as general paralysis of the insane (GPI) or paralytic dementia, is a severe neuropsychiatric disorder, classified as an organic mental disorder and caused by the chronic meningoencephalitis that leads to cerebral atrophy in late-stage syphilis. Degenerative changes are associated primarily with the frontal and temporal lobar cortex. The disease affects approximately 7% of infected individuals. It is more common among men.

The sign was described by Sir James Crichton-Browne. [1]

James Crichton-Browne British psychiatrist

Sir James Crichton-Browne MD FRS FRSE was a leading British psychiatrist, neurologist and medical psychologist. He is known for studies on the relationship of mental illness to brain injury and for the development of public health policies in relation to mental health. Crichton-Browne's father was the asylum reformer Dr William A.F. Browne, a prominent member of the Edinburgh Phrenological Society and, from 1838 until 1857, the superintendent of the Crichton Royal at Dumfries where Crichton-Browne spent much of his childhood.

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The Crichton Hospital in Scotland

The Crichton is an institutional campus in Dumfries in southwest Scotland. It serves as a remote campus for the University of Glasgow, the University of the West of Scotland, Dumfries and Galloway College, and the Open University. The site also includes a hotel and conference centre, and Crichton Memorial Church, set in a 100-acre (40 ha) park. The campus was established in the 19th century as the Crichton Royal Hospital, a psychiatric hospital.

Edinburgh Phrenological Society learned society for phrenology

The Edinburgh Phrenological Society was founded in 1820 by lawyer George Combe and his physician brother Andrew. The Edinburgh Society was the first and foremost phrenological grouping in Great Britain; more than forty phrenological societies followed in other parts of the British Isles. The Society's influence was greatest over the next two decades but declined in the 1840s; the final meeting was recorded in 1870.

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James Browne may refer to:

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William A. F. Browne British doctor

Dr William Alexander Francis Browne (1805–1885) was one of the most significant asylum doctors of the nineteenth century. At Montrose Asylum (1834–1838) in Angus and at the Crichton Royal in Dumfries (1838–1857), Browne introduced activities for patients including writing, group activity and drama, pioneered early forms of occupational therapy and art therapy, and initiated one of the earliest collections of artistic work by patients in a psychiatric hospital. In an age which rewarded self-control, Browne encouraged self-expression and may thus be counted alongside William Tuke, Vincenzo Chiarugi and John Conolly as one of the pioneers of the moral treatment of mental illness. Sociologist Andrew Scull has identified Browne's career with the institutional climax of nineteenth century psychiatry.

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