Ayahuasca is a South American psychoactive and entheogenic brewed drink traditionally used both socially and as a ceremonial or shamanic spiritual medicine among the indigenous peoples of the Amazon basin, and more recently in Western society. The tea causes altered states of consciousness often known as "psychedelic experiences" which include visual hallucinations and altered perceptions of reality.
N,N-Dimethyltryptamine is a substituted tryptamine that occurs in many plants and animals, including human beings, and which is both a derivative and a structural analog of tryptamine. It is used as a psychedelic drug and prepared by various cultures for ritual purposes as an entheogen.
Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states and/or an apparent expansion of consciousness. Sometimes, they are called classic hallucinogens, serotonergic hallucinogens, or serotonergic psychedelics, and the term psychedelic is sometimes used more broadly to include various types of hallucinogens or those which are atypical or adjacent to psychedelia such as MDMA or cannabis; this article uses the narrower definition of psychedelics. True psychedelics cause specific psychological, visual, and auditory changes, and oftentimes a substantially altered state of consciousness. Psychedelic states are often compared to meditative, psychodynamic or transcendental types of alterations of mind. The "classical" psychedelics, the psychedelics with the largest scientific and cultural influence, are mescaline, LSD, psilocybin, and DMT. LSD in particular has long been considered the paradigmatic psychedelic compound, to which all other psychedelics are often or usually compared.
Ralph Herman Abraham is an American mathematician. He has been a member of the faculty of the University of California, Santa Cruz since 1968.
Terence Kemp McKenna was an American ethnobotanist and mystic who advocated the responsible use of naturally occurring psychedelic plants. He spoke and wrote about a variety of subjects, including psychedelic drugs, plant-based entheogens, shamanism, metaphysics, alchemy, language, philosophy, culture, technology, environmentalism, and the theoretical origins of human consciousness. He was called the "Timothy Leary of the '90s", "one of the leading authorities on the ontological foundations of shamanism", and the "intellectual voice of rave culture".
Joseph James Rogan is an American UFC color commentator, podcaster, comedian, actor, and former television presenter. He hosts The Joe Rogan Experience, a podcast in which he discusses current events, comedy, politics, philosophy, science, and hobbies with a variety of guests.
5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine) or O-methyl-bufotenin is a psychedelic of the tryptamine class. It is found in a wide variety of plant species, and also is secreted by the glands of at least one toad species, the Colorado River toad. Like its close relatives DMT and bufotenin (5-HO-DMT), it has been used as an entheogen in South America. Slang terms include Five-methoxy, The power, and Toad venom.
Dennis Jon McKenna is an American ethnopharmacologist, research pharmacognosist, lecturer and author. He is the brother of well-known psychedelics proponent Terence McKenna and is a founding board member and the director of ethnopharmacology at the Heffter Research Institute, a non-profit organization concerned with the investigation of the potential therapeutic uses of psychedelic medicines.
Rick Strassman is an American clinical associate professor of psychiatry at the University of New Mexico School of Medicine. He has held a fellowship in clinical psychopharmacology research at the University of California San Diego and was Professor of Psychiatry for eleven years at the University of New Mexico. After 20 years of intermission, Strassman was the first person in the United States to undertake human research with psychedelic, hallucinogenic, or entheogenic substances with his research on N,N-dimethyltryptamine, also known as DMT. He is also the author of DMT: The Spirit Molecule, which summarizes his academic research into DMT and other experimental studies of it, and includes his own reflections and conclusions based on this research.
O-Acetylpsilocin is a semi-synthetic psychoactive drug that has been suggested by David Nichols to be a potentially useful alternative to psilocybin for pharmacological studies, as they are both believed to be prodrugs of psilocin. However, some users report that O-acetylpsilocin's subjective effects differ from those of psilocybin and psilocin. Additionally, some users prefer 4-AcO-DMT to natural psilocybin mushrooms due to feeling fewer adverse side effects such as nausea and heavy body load, which are more frequently reported in experiences involving natural mushrooms. It is the acetylated form of the psilocybin mushroom alkaloid psilocin and is a lower homolog of 4-AcO-MET, 4-AcO-DET, 4-AcO-MiPT and 4-AcO-DiPT.
5-Bromo-DMT (5-bromo-N,N-dimethyltryptamine) is a psychedelic brominated indole alkaloid found in the sponges Smenospongia aurea and Smenospongia echina, as well as in Verongula rigida alongside 5,6-Dibromo-DMT and seven other alkaloids. It is the 5-bromo derivative of DMT, a psychedelic found in many plants and animals.
Stephen István Szára was a Hungarian-American chemist and psychiatrist who made major contributions in the field of pharmacology.
Honey, I Shrunk the Kids is an American media franchise consisting of a series of family-science fiction-comedy films and a television adaptation, among other works, based on a concept created by Stuart Gordon and Brian Yuzna, and an original story co-written by Gordon, Yuzna, and Ed Naha. Following the release of Honey, I Shrunk the Kids (1989), and its subsequent financial and critical success, two sequels and a television series followed; titled Honey, I Blew Up the Kid (1992), Honey, We Shrunk Ourselves (1997), and Honey, I Shrunk the Kids: The TV Show, respectively. Another sequel titled Shrunk entered development in 2019.
The Joe Rogan Experience is a podcast hosted by American comedian, presenter, and UFC color commentator Joe Rogan. It launched on December 24, 2009, on YouTube by Rogan and comedian Brian Redban, who was its sole co-host and producer until 2012 when Jamie Vernon was hired to co-produce. Vernon would eventually take over production. By 2015, it was one of the world's most popular podcasts, regularly receiving millions of views per episode, also including a wide array of guests, including business magnate Elon Musk, whistleblower Edward Snowden, and Senator Bernie Sanders. Since December 2020, the podcast has been exclusively available on Spotify, with highlights uploaded onto the main Joe Rogan Experience YouTube channel. The podcast was originally recorded at Rogan's home in California, before moving to a private studio in Woodland Hills, Los Angeles. Production was relocated to Austin, Texas after the podcast was exclusively licensed on Spotify in 2020.
Andrew "Andy" C. Stone is an American computer programmer best known for his iOS app Twittelator, which to date has sold over a million units for the iPhone and the iPad. The founder, director, and principal programmer for Stone Design Corporation, Albuquerque, New Mexico. In his 25 plus year career as a programmer, he has published over 35 software titles for Hypercard, the NeXT workstation, Mac OS X, and for iOS iPhones and iPads. He retired from software development in 2015.
Hamilton Morris is an American journalist, documentarian, and scientific researcher. He is the creator and director of the television series Hamilton's Pharmacopeia, in which he investigates the chemistry, history, and cultural impact of various psychoactive drugs.
James Fadiman is an American writer known for his research on microdosing psychedelics. He co-founded the Institute of Transpersonal Psychology, which later became Sofia University.
This is an overview of the legality of ayahuasca by country. DMT, one of the active ingredients in ayahuasca, is classified as a Schedule I drug under the United Nations 1971 Convention on Psychotropic Substances, meaning that international trade in DMT is supposed to be closely monitored; use of DMT is supposed to be restricted to scientific research and medical use. Natural materials containing DMT, including ayahuasca, are not regulated under the 1971 Psychotropic Convention. The majority of the world's nations classify DMT as a scheduled drug; however, few countries seem to have laws specifically addressing the possession or use of ayahuasca.
How to Change Your Mind: What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence is a 2018 book by Michael Pollan. It became a No. 1 New York Times best-seller.
Psychoplastogens are a group of small molecule drugs that produce rapid and sustained effects on neuronal structure and function, intended to manifest therapeutic benefit after a single administration. Several existing psychoplastogens have been identified and their therapeutic effects demonstrated; several are presently at various stages of development as medications including Ketamine, MDMA, Scopolamine, and the serotonergic psychedelics, including LSD, psilocin – the active metabolite of psilocybin, DMT, and 5-MeO-DMT. Compounds of this sort are being explored as therapeutics for a variety of brain disorders including depression, addiction, and PTSD. The ability to rapidly promote neuronal changes via mechanisms of neuroplasticity was recently discovered as the common therapeutic activity and mechanism of action.
