DTaP-IPV/Hib vaccine

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DTaP-IPV/Hib vaccine
Combination of
DTaP vaccine Vaccine
Inactivated poliovirus vaccine Vaccine
Hib vaccine Vaccine
Clinical data
Trade names Pentacel, Pediacel, Infanrix IPV + Hib, others
AHFS/Drugs.com FDA Professional Drug Information
Routes of
administration 		Intramuscular injection
ATC code
Legal status
Legal status
Identifiers
CAS Number

DTaP-IPV/Hib vaccine is a 5-in-1 combination vaccine that protects against diphtheria, tetanus, whooping cough, polio, and Haemophilus influenzae type B. [1] [2]

Contents

Its generic name is "diphtheria and tetanus toxoids and acellular pertussis adsorbed, inactivated poliovirus and haemophilus B conjugate vaccine", and it is also known as DTaP-IPV-Hib. [1]

Uses

DTaP-IPV/Hib vaccine is administered to young children to immunise against diphtheria, tetanus, pertussis, poliomyelitis, and diseases caused by Haemophilus influenzae type B . [1]

Formulations

A branded formulation marketed in the United States is Pentacel, manufactured by Sanofi Pasteur. [3]

Pentacel is known in the UK and Canada as Pediacel. [4] [5]

An equivalent vaccine marketed in the UK and Canada by GlaxoSmithKline is Infanrix IPV + Hib. [5] This is a two-part vaccine. The DTaP-IPV component is supplied as a sterile liquid, which is used to reconstitute lyophilized (freeze-dried) Hib vaccine.[ citation needed ]

Pentaxim is a liquid formulation marketed by Sanofi Pasteur. [6]

Availability

It is only licensed for young children. [7] The United States Food and Drug Administration has approved[ when? ] the vaccine for children from age 6 weeks up to age 5 years. [1] It was used in the UK until 2017, following which a 6-in-1 vaccine became available containing the additional protection against Hepatitis B. [2]

References

  1. 1 2 3 4 "Diphtheria and Tetanus Toxoids, Acellular Pertussis, Poliovirus and Haemophilus b Conjugate Vaccine". Drugs.com. Retrieved 15 July 2018.
  2. 1 2 "5-in-1 Vaccine (also called Pentavalent Vaccine)". Vaccine Knowledge Project. 3 January 2021. Retrieved 3 July 2018.
  3. ↑ "Pentacel". U.S. Food and Drug Administration(FDA). STN 125145. Retrieved 15 July 2018.
  4. ↑ "Pediacel syringe - Summary of Product Characteristics (SmPC)". Datapharm. 17 April 2019. Archived from the original on 17 October 2019. Retrieved 16 October 2019.
  5. 1 2 "Diphteria Toxoid: Canadian Immunization Guide". Public Health Agency of Canada. December 2014. Archived from the original on 24 September 2019. Retrieved 16 October 2019.
  6. ↑ Plotkin SA, Liese J, Madhi SA, Ortiz E (July 2011). "A DTaP-IPV/PRP~T vaccine (Pentaxim): a review of 16 years' clinical experience". Expert Rev Vaccines. 10 (7): 981–1005. doi:10.1586/erv.11.72. PMID   21749196. S2CID   207224675.
  7. ↑ "Diphtheria toxoid / haemophilus b conjugate (prp-t) vaccine / pertussis, acellular / poliovirus vaccine, inactivated / tetanus toxoid (Pentacel) Use During Pregnancy". Drugs.com. Retrieved 2 January 2021.
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