Daniel Senzile Ndima is a South African structural biologist of infectious diseases and bio-entrepreneur. His specialty is in genetic/protein engineering and protein crystallography. He is the founding CEO of CapeBio. He is an Allan Gray Orbis fellow and The Mandela Rhodes Scholar. The CapeBio company has developed a coronavirus testing kit. The kit is called qPCR. The Coronavirus test kits produce results in 65 minutes. [1] [2] [3] Ndima says, “Our kits help pathologists isolate and identify a virus’s DNA or genetic material from an infected person. This makes it possible to detect the virus accurately in a laboratory.” [4] [5] [6] [7]
Ndima was born in Eastern Cape and grew up in Cape Town. He earned a bachelor's degree in biotechnology from University of the Western Cape. [8] In 2016, he earned a master's degree in biochemistry from the University of Pretoria; his thesis was Investigating the Potentially Expanded Target Repertoire of Murinized Internalin of Listeria Monocytogenes [9]
Following graduation, he joined the Council for Scientific and Industrial Research as a researcher and business developer for CapeBio Initiative which ultimately became CapeBio Technologies. Ndima is an Allan Gray Orbis Foundation Fellow, and the founding CEO of CapeBio Technologies. The Allan Gray Orbis Foundation was founded by Allan Gray (investor). Ndima worked with a group of researchers at CSIR that developed reagents enzymes as business developer of the start-up and product developer. The company produces molecular biology reagents, enzymes and kits which are used at universities, research councils, and companies in South Africa and United States. [10] [11] [12] [13] [14] [15]
Listeria monocytogenes is the species of pathogenic bacteria that causes the infection listeriosis. It is a facultative anaerobic bacterium, capable of surviving in the presence or absence of oxygen. It can grow and reproduce inside the host's cells and is one of the most virulent foodborne pathogens. Twenty to thirty percent of foodborne listeriosis infections in high-risk individuals may be fatal. In the European Union, listeriosis continues an upward trend that began in 2008, causing 2,161 confirmed cases and 210 reported deaths in 2014, 16% more than in 2013. In the EU, listeriosis mortality rates also are higher than those of other foodborne pathogens. Responsible for an estimated 1,600 illnesses and 260 deaths in the United States annually, listeriosis ranks third in total number of deaths among foodborne bacterial pathogens, with fatality rates exceeding even Salmonella spp. and Clostridium botulinum.
Listeria is a genus of bacteria that acts as an intracellular parasite in mammals. By 2024, 28 species had been identified. The genus is named in honour of the British pioneer of sterile surgery Joseph Lister. Listeria species are Gram-positive, rod-shaped, and facultatively anaerobic, and do not produce endospores.
Listeriosis is a bacterial infection most commonly caused by Listeria monocytogenes, although L. ivanovii and L. grayi have been reported in certain cases. Listeriosis can cause severe illness, including severe sepsis, meningitis, or encephalitis, sometimes resulting in lifelong harm and even death. Those at risk of severe illness are the elderly, fetuses, newborns and those who are immunocompromised. In pregnant women it may cause stillbirth or spontaneous abortion, and preterm birth is common. Listeriosis may cause mild, self-limiting gastroenteritis and fever in anyone.
Pascale Cossart is a French bacteriologist who is affiliated with the Pasteur Institute of Paris. She is the foremost authority on Listeria monocytogenes, a deadly and common food-borne pathogen responsible for encephalitis, meningitis, bacteremia, gastroenteritis, and other diseases.
Victoria Girls' High School is a state (public) school in Grahamstown, South Africa with a 100% pass rate and 94% endorsement. It is a girls-only school that caters for learners from Grade 8 to Grade 12. Victoria Girls' High School is a leading school in the province. It has repeatedly produced the top matric pupil in its educational district of Cacadu. VGHS has twice, in 2007 and again in 2011, been the winner of the PetroSA Proudly South African HomeGrown Awards, "Educational Institute of the Year." The school is also a member of the Allan Gray Orbis Foundation's "Circle of Excellence. Victoria Girls' High has also been placed sixth in the Eastern Cape based on its outstanding Mathematics and Science results. Victoria Girls' High School also offers boarding facilities ranging from small and homely to large and social. Victoria Girls' High offers a wide range of facilities including the Johan Carinus Art Centre, computer centres, three science labs and a ninety-seat audio-visual presentation venue. Currently under construction is a new music centre.
Cognician is a web-based, e-learning platform for personal development and organisational development produced by Cognician Software (Pty) Ltd. The company is located in Cape Town, South Africa, and San Jose, California, and was founded by brothers Barry Kayton and Patrick Kayton in 2010.
Cepheid is an American molecular diagnostics company that is a wholly owned subsidiary of Danaher Corporation. Its systems automate traditional nucleic acid tests. The tests can be used to identify and analyze pathogens and genetic disorders. Cepheid sells clinical tests for healthcare-associated infections, infectious diseases, sexual health, oncology and genetics.
Allan Gray is an investment management firm headquartered in South Africa, established with the objective of offering a range of investments. In addition to its primary location, the firm has expanded its operations to include offices in Botswana, Namibia, and Eswatini, reflecting its broader geographic reach within the region. It also works in collaboration with sister companies, Orbis Investment Management and Allan Gray Australia, to leverage global investment insights and strategies. Allan Gray caters to a diverse clientele, which encompasses both institutional and individual investors, along with insurance companies, trusts, foundations, and foreign institutions. This diverse client base is indicative of the firm's comprehensive service offering, designed to meet a variety of investment needs.
Allan William Buchanan Gray was a South African billionaire businessman and philanthropist. He founded the privately owned investment management company named after him, and the non-profit Allan Gray Orbis Foundation, and the Allan and Gill Gray Charitable Trust. Before he donated his stake in the Allan Gray investment management company, his net worth was estimated to have been US$1.8 billion in 2017.
The 2017–2018 South African listeriosis outbreak, also known as Listeriosis Histeriosis, was a widespread outbreak of Listeria monocytogenes food poisoning that resulted from contaminated processed meats produced by Enterprise Foods, a subsidiary of Tiger Brands, in Polokwane. There were 1,060 confirmed cases of listeriosis during the outbreak, and about 216 deaths. It is the world's deadliest listeriosis outbreak.
Events in the year 2020 in South Africa.
Primerdesign is a UK-based biotechnology company that designs and sells products for quantitative real-time polymerase chain reaction (qPCR).
COVID-19 testing involves analyzing samples to assess the current or past presence of SARS-CoV-2, the virus that cases COVID-19 and is responsible for the COVID-19 pandemic. The two main types of tests detect either the presence of the virus or antibodies produced in response to infection. Molecular tests for viral presence through its molecular components are used to diagnose individual cases and to allow public health authorities to trace and contain outbreaks. Antibody tests instead show whether someone once had the disease. They are less useful for diagnosing current infections because antibodies may not develop for weeks after infection. It is used to assess disease prevalence, which aids the estimation of the infection fatality rate.
The COVID-19 pandemic in South Africa was part of the pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Sindiswa Griselda Gomba is a South African politician who was the Eastern Cape MEC for Health from 2019 to 2021. She became a Member of the Eastern Cape Provincial Legislature in March 2019. Gomba is a member of the African National Congress (ANC) and previously served as a municipal councillor of the Buffalo City Metropolitan Municipality.
The Beta variant, (B.1.351), was a variant of SARS-CoV-2, the virus that causes COVID-19. One of several SARS-CoV-2 variants initially believed to be of particular importance, it was first detected in the Nelson Mandela Bay metropolitan area of the Eastern Cape province of South Africa in October 2020, which was reported by the country's health department on 18 December 2020. Phylogeographic analysis suggests this variant emerged in the Nelson Mandela Bay area in July or August 2020.
COVID-19 testing in the Republic of Ireland can identify whether a person is infected with SARS-CoV-2, the virus which causes COVID-19. The developing and delivering of testing of Ireland was led by the staff in the National Virus Reference Laboratory. With the acquisition of the sequence of the virus, they used this to develop and validate in-house assays in advance of obtaining any commercial diagnostic kits. The NVRL played a vital role in the early detection of COVID-19 cases in Ireland, and began playing a vital role in the detection of new variants of COVID-19 in 2021.
The ImmunityBio COVID-19 vaccine, codenamed hAd5, is a non replicating viral vector COVID-19 vaccine developed by the United States-based pharmaceutical company ImmunityBio.