Denise R. Aberle | |
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Academic background | |
Education | MD, 1979, University of Kansas School of Medicine |
Academic work | |
Institutions | David Geffen School of Medicine at UCLA UCLA Henry Samueli School of Engineering and Applied Science |
Denise R. Aberle is an American radiologist and oncologist. As a professor of radiology in the David Geffen School of Medicine at UCLA and a professor of bioengineering in the UCLA Henry Samueli School of Engineering and Applied Science,Aberle was elected a member of the National Academy of Medicine and Fellow of the American Institute for Medical and Biological Engineering.
Aberle completed her medical degree from the University of Kansas School of Medicine and completed her fellowship at the University of California,San Francisco. [1]
Upon completing her residency and fellowship,Aberle joined the faculty at the David Geffen School of Medicine at UCLA. While working there,she was also named to lead the National Lung Screening Trial (NLST) in 2011. Her research team found that administering CT scans for high-risk patients saved their lives,pushing for more support for CT scans for bladder cancer survivors. [2] She followed this up by publishing the first annual screening examinations NLST in 2013,showing that low-dose CT scans could detect early-stage lung cancer at a faster rate than chest X-ray. [3] In recognition of her work with the NLST,she received the 2014 Clinical Research Achievement Award from Clinical Research Forum. [4]
As a professor of radiology in the David Geffen School of Medicine at UCLA and a professor of bioengineering in the UCLA Henry Samueli School of Engineering and Applied Science,Aberle was the principal investigator of a project to develop liquid biopsy tools for testing individuals who could have lung cancer. [5] In recognition of her work,she was also elected a Fellow of the American Institute for Medical and Biological Engineering. [6]
In 2019,Aberle was elected a member of the National Academy of Medicine for "leading the American College of Radiology Imaging Network in the National Cancer Institute–sponsored National Lung Screening Trial,in which low-dose CT screening was shown to reduce mortality from lung cancer by 20% compared with chest radiographic screening." [7] She also received the International Association for the Study of Lung Cancer’s Joseph W. Cullen Prevention/Early Detection Award for her "lifetime contributions to the prevention of lung cancer or other thoracic malignancies." [8]
A computed tomography scan is a medical imaging technique used to obtain detailed internal images of the body. The personnel that perform CT scans are called radiographers or radiology technologists.
In medical or research imaging,an incidental imaging finding is an unanticipated finding which is not related to the original diagnostic inquiry. As with other types of incidental medical findings,they may represent a diagnostic,ethical,and philosophical dilemma because their significance is unclear. While some coincidental findings may lead to beneficial diagnoses,others may lead to overdiagnosis that results in unnecessary testing and treatment,sometimes called the "cascade effect".
Virtual colonoscopy is the use of CT scanning or magnetic resonance imaging (MRI) to produce two- and three-dimensional images of the colon,from the lowest part,the rectum,to the lower end of the small intestine,and to display the images on an electronic display device. The procedure is used to screen for colon cancer and polyps,and may detect diverticulosis. A virtual colonoscopy can provide 3D reconstructed endoluminal views of the bowel. VC provides a secondary benefit of revealing diseases or abnormalities outside the colon.
A chest radiograph,called a chest X-ray (CXR),or chest film,is a projection radiograph of the chest used to diagnose conditions affecting the chest,its contents,and nearby structures. Chest radiographs are the most common film taken in medicine.
Henry Samueli is an American businessman,engineer,and philanthropist.
Lung cancer screening refers to cancer screening strategies used to identify early lung cancers before they cause symptoms,at a point where they are more likely to be curable. Lung cancer screening is critically important because of the incidence and prevalence of lung cancer. More than 235,000 new cases of lung cancer are expected in the United States in 2021 with approximately 130,000 deaths expected in 2021. In addition,at the time of diagnosis,57% of lung cancers are discovered in advanced stages,meaning they are more widespread or aggressive cancers. Because there is a substantially higher probability of long-term survival following treatment of localized (60%) versus advanced stage (6%) lung cancer,lung cancer screening aims to diagnose the disease in the localized stage.
In radiology,the tree-in-bud sign is a finding on a CT scan that indicates some degree of airway obstruction. The tree-in-bud sign is a nonspecific imaging finding that implies impaction within bronchioles,the smallest airway passages in the lung. The differential for this finding includes malignant and inflammatory etiologies,either infectious or sterile. This includes fungal infections,mycobacterial infections such as tuberculosis or mycobacterium avium intracellulare,bronchopneumonia,chronic aspiration pneumonia,cystic fibrosis or cellular impaction from bronchovascular spread of malignancy,as can occur with breast cancer,leukemia or lymphoma. It also includes lung manifestations of autoimmune diseases such as Sjögren syndrome or rheumatoid arthritis.
The UCLA Henry Samueli School of Engineering and Applied Science,informally known as UCLA Samueli School of Engineering or UCLA Engineering,is the school of engineering at the University of California,Los Angeles (UCLA). It opened as the College of Engineering in 1945 and was renamed the School of Engineering in 1969. Since its initial enrollment of 379 students,the school has grown to approximately 6,500 students. The school offers 28 degree programs and is home to eight externally funded interdisciplinary research centers,including those in space exploration,wireless sensor systems,and nanotechnology.
A lung nodule or pulmonary nodule is a relatively small focal density in the lung. A solitary pulmonary nodule (SPN) or coin lesion,is a mass in the lung smaller than three centimeters in diameter. A pulmonary micronodule has a diameter of less than three millimetres. There may also be multiple nodules.
Joseph W. Cullen was an American cancer prevention and rehabilitation researcher and briefly director of the AMC Cancer Research Center (1989-1990). He previously worked at the VA Hospital in Maryland (1968-1973),the National Institutes of Health (1973),the National Cancer Institute (NCI),and the Jonsson Comprehensive Cancer Center (1976-1982),holding high-level positions such as division director at several. He was a coordinator,creator,and researcher for the Smoking Tobacco and Cancer Program at the NCI,the largest anti-smoking campaign in the world at that time. Cullen wrote more than 90 publications in his lifetime,including four books.
In medicine,the Golden S sign is a sign seen on imaging of the chest that suggests a central lung mass or lung collapse. It was first described by Dr. Ross Golden (1889-1975) in 1925 in association with bronchial carcinoma,but it is also seen in metastatic cancer,enlarged lymph nodes,and collapse of the right upper lobe of the lung.
Asbestos-related diseases are disorders of the lung and pleura caused by the inhalation of asbestos fibres. Asbestos-related diseases include non-malignant disorders such as asbestosis,diffuse pleural thickening,pleural plaques,pleural effusion,rounded atelectasis and malignancies such as lung cancer and malignant mesothelioma.
The National Lung Screening Trial was a United States-based clinical trial which recruited research participants between 2002 and 2004. It was sponsored by the National Cancer Institute and conducted by the American College of Radiology Imaging Network and the Lung Screening Study Group. The major objective of the trial was to compare the efficacy of low-dose helical computed tomography and standard chest X-ray as methods of lung cancer screening. The primary study ended in 2010,and the initial findings were published in November 2010,with the main results published in 2011 in the New England Journal of Medicine.
Emphysema is any air-filled enlargement in the body's tissues. Most commonly emphysema refers to the enlargement of air spaces (alveoli) in the lungs,and is also known as pulmonary emphysema.
Maryellen L. Giger, is an American physicist and radiologist who has made significant contributions to the field of medical imaging.
Kimberlee Jane Kearfott is a professor in the Department of Nuclear Engineering and Radiological Sciences at University of Michigan in Ann Arbor,Michigan. The American Nuclear Society recognised her notable contributions to the field of radiation protection in 2017.
Judy Yee is an American radiologist. She is the University Chair of Radiology at Montefiore and professor of radiology at Albert Einstein College of Medicine.
Danijela Branislav Cabric is an Serbian-American electrical engineer. She is an associate professor in the Department of Electrical and Computer Engineering at the University of California,Los Angeles. During the COVID-19 pandemic,Cabric was elected a Fellow of the Institute of Electrical and Electronics Engineers (IEEE) for her "contributions to theory and practice of spectrum sensing and cognitive radio systems."
Beth Young Karlan is an American gynecologic oncologist. In 2008,she was named editor-in-chief of the medical journals Gynecologic Oncology and Gynecologic Oncology Reports. In 2012,Karlan was appointed by the White House to serve on the National Cancer Advisory Board,and in 2015,she was elected to the National Academy of Medicine.
Sergey Pavlovich Morozov is a Russian radiologist and healthcare official.
Denise Aberle publications indexed by Google Scholar