Department of Chemistry, University of York

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Department of Chemistry, University of York
Chemistry A Block and Chemistry Bridge - geograph.org.uk - 4719065.jpg
The outside of Chemistry A Block
Type Academic department
Established1965
Affiliation University of York
Head of DepartmentProfessor Caroline Dessent
Academic staff
60
Undergraduates 620
Postgraduates 200
Location
York, Yorkshire, England
Website www.york.ac.uk/chemistry/

The Department of Chemistry at the University of York opened in 1965 with Sir Richard Norman being the founding professor of the department. [1] The department has since grown to over 820 students and provides both undergraduate and postgraduate courses in Chemistry and other related fields, with the current Head of department being Professor Caroline Dessent. [2]

Contents

Research

Chemistry Research Centres

Centre for Hyperpolarisation in Magnetic Resonance

The Centre for Hyperpolarisation in Magnetic Resonance is a interdisciplinary research centre jointly-run with the Department of Psychology, with a focus on the development of techniques for nuclear magnetic resonance and magnetic resonance imaging. [3] The centre is primarily located on York Science Park housing high resolution NMR machines and a 7 T pre-clinical MRI scanner. [4] Recent research has focused on Nitrogen-15 Hyperpolarized Nuclear Magnetic Resonance to study Nitrogen cycle Synthons. [5] The centre has also been working on research involving the tracking of anticancer agents for use in MRI. [6]

Centre of Excellence in Mass Spectrometry

Created in 2008 the centre is a joint venture with the Department of Biology and is currently based in the York Science Park. Research areas are very broad and range from therapeutic protein discovery to supporting archaeological research. [7]

Green Chemistry Centre of Excellence

Woldson Atmospheric Chemistry Laboratories Wolfson Atmospheric Chemistry Laboratories - geograph.org.uk - 4282599.jpg
Woldson Atmospheric Chemistry Laboratories

The research centre is associated with both the Biorenewables Development Centre and Centre for Novel Agricultural Products and focuses on making changes to help promote low carbon and bio-based economy. [8] [9] Recent research had led to exploration of harvesting fog for a renewable source of water and development of absorption techniques to reduce the impact of pollutants on the environment. [10] [11]

Wolfson Atmospheric Chemistry Laboratories

Established in 2013, the research group studies and develops technology for atmospheric science with key areas of focus including air pollution as well as ozone depleting substances. [12] The group also runs the Cape Verde Atmospheric Observatory studying the effects of nitrogen oxides and various other pollutants are having on the environment. [13]

Facilities

Developments

Outside of the Dorothy Hodgkin Building Dorothy Hodgkin Building - geograph.org.uk - 482387.jpg
Outside of the Dorothy Hodgkin Building

Since 2010 the Department of Chemistry has undergone £29 million of renovations with the development of phase 2 of the Dorothy Hodgkin research building. The 3 story building costing £9.4 million provides space for 100 researchers with research interests ranging from medical chemistry to solar energy. A secondary development consisting of chemistry F block was completed in 2014. The site provides new undergraduate facilities and social space. The top floor of the research building also houses the Green Chemistry centre of Excellence. [14] The centres for Biorenewables Development and Centre for Hyperpolarisation in Magnetic Resonance have also recently undergone developments. [15]

Associated departments and research centres

Related Research Articles

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References

  1. "About the Department - Chemistry, University of York". University of York. Archived from the original on 24 May 2023. Retrieved 23 May 2023.
  2. "Academic staff - About staff, University of York". University of York. Archived from the original on 15 May 2023. Retrieved 23 May 2023.
  3. "Centre for Hyperpolarisation in Magnetic Resonance - Centre for Hyperpolarisation in Magnetic Resonance, University of York". University of York. Archived from the original on 15 May 2023. Retrieved 23 May 2023.
  4. "About us - Centre for Hyperpolarisation in Magnetic Resonance, University of York". University of York. Archived from the original on 4 April 2023. Retrieved 23 May 2023.
  5. Rayner, Peter J.; Fekete, Marianna; Gater, Callum A.; Ahwal, Fadi; Turner, Norman; Kennerley, Aneurin J.; Duckett, Simon B. (18 May 2022). "Real-Time High-Sensitivity Reaction Monitoring of Important Nitrogen-Cycle Synthons by 15 N Hyperpolarized Nuclear Magnetic Resonance". Journal of the American Chemical Society. 144 (19): 8756–8769. doi:10.1021/jacs.2c02619. ISSN   0002-7863. PMC   9121385 . PMID   35508182.
  6. Fear, Elizabeth J.; Kennerley, Aneurin J.; Rayner, Peter J.; Norcott, Philip; Roy, Soumya S.; Duckett, Simon B. (7 March 2022). "SABRE hyperpolarized anticancer agents for use in 1 H MRI". Magnetic Resonance in Medicine. 88 (1): 11–27. doi:10.1002/mrm.29166. ISSN   0740-3194. PMC   9310590 . PMID   35253267. Archived from the original on 25 December 2022. Retrieved 23 May 2023.
  7. "About us - Centre of Excellence in Mass Spectrometry, University of York". University of York. Archived from the original on 17 February 2023. Retrieved 23 May 2023.
  8. "Introduction to Green Chemistry - Chemistry, University of York". University of York. Archived from the original on 25 February 2023. Retrieved 23 May 2023.
  9. York, University of (24 March 2023). "Green Chemistry Centre of Excellence - Research, University of York". University of York. Archived from the original on 6 May 2023. Retrieved 23 May 2023.
  10. Mistry, Kishan; Hurst, Glenn A. (11 October 2022). "A Simple Setup to Explore Fog Harvesting as a Clean and Sustainable Source of Water". Journal of Chemical Education. 99 (10): 3553–3557. doi: 10.1021/acs.jchemed.2c00018 . ISSN   0021-9584.
  11. Abdoul, Hayman J.; Yi, Minghao; Prieto, Manuel; Yue, Hangbo; Ellis, Gary J.; Clark, James H.; Budarin, Vitaliy L.; Shuttleworth, Peter S. (15 March 2023). "Efficient adsorption of bulky reactive dyes from water using sustainably-derived mesoporous carbons". Environmental Research. 221: 115254. doi:10.1016/j.envres.2023.115254. hdl: 10261/329510 . ISSN   0013-9351. Archived from the original on 29 March 2023. Retrieved 23 May 2023.
  12. "Wolfson Atmospheric Chemistry Laboratories - Research, University of York". University of York. Archived from the original on 15 May 2023. Retrieved 23 May 2023.
  13. "Scientists search for new source of air pollutants over Cape Verde". NCAS. 18 March 2020. Archived from the original on 22 March 2023. Retrieved 23 May 2023.
  14. "Chemistry F block". University of York. Archived from the original on 15 May 2023. Retrieved 23 May 2023.
  15. "Chemistry New Buildings Project - Chemistry, University of York". University of York. Archived from the original on 26 February 2023. Retrieved 23 May 2023.