The drop is an approximated unit of measure of volume, the amount dispensed as one drop from a dropper or drip chamber. It is often used in giving quantities of liquid drugs to patients, and occasionally in cooking and in organic synthesis. The abbreviations gt or gtt come from the Latin noun gutta ("drop").
The volume of a drop is not well defined: it depends on the device and technique used to produce the drop, on the strength of the gravitational field, and on the viscosity, density, and the surface tension of the liquid. [1]
Several exact definitions exist:
In organic synthesis, a synthetic procedure will often call for the addition of a reagent "dropwise" with the aid of a syringe or a dropping funnel. The rate of addition for such a procedure is taken to be slow but is otherwise vague: one chemist might consider dropwise to be one drop per second, another five to ten drops per second (almost a stream). Furthermore, needle gauge or the dimensions of the glassware also affect drop volume. To improve reproducibility, experimental procedures also note the total amount of time required to add the liquid or another measure of addition rate. In a related usage, the amount of a reagent, whose precise quantity is unimportant, will sometimes be given in terms of the number of drops, often from a glass pipette. In this usage, a drop is typically considered to be approximately 0.05 ml. The practice of giving quantities this way has declined in usage.
In the first decade of the 19th century, the minim, the smallest unit of Apothecary Measure, was promoted by the pharmaceutical and medical establishments as an alternative to the drop. [3] It was noted that the size of a drop can vary considerably depending on the viscosity and specific gravity of the fluid, as well as the size and shape of the vessel from which it is poured. (At the time, surface tension was not well understood.) The minim came with a set of procedures for ensuring accurate measurement, specifically, diluting powerful medicines that had previously been measured by the drop, then using a "minimometer" or "minim glass" (graduated pipette) with minim marks at regular intervals. The minim was defined as one 60th of a fluid dram or one 480th of a fluid ounce. [4] This is equal to about 61.6 μL (U.S.) or 59.2 μL (Britain).
Pharmacists have since moved to metric measurements, with a drop being rounded to exactly 0.05 mL (50 μL, that is, 20 drops per milliliter). In hospitals, intravenous tubing is used to deliver medication in drops of various sizes ranging from 10 drops/mL to 60 drops/mL. A drop is abbreviated gtt, with gtts used for the plural, often seen on prescriptions. [5] Other sources abbreviate gt for singular, and gtt for plural. [6] [7] These abbreviations come from gutta (plural guttae), the Latin word for drop. [8] [5]
A teaspoon (tsp.) is an item of cutlery. It is a small spoon that can be used to stir a cup of tea or coffee, or as a tool for measuring volume. The size of teaspoons ranges from about 2.5 to 7.3 mL. For cooking purposes and dosing of medicine, a teaspoonful is defined as 5 mL, and standard measuring spoons are used.
United States customary units form a system of measurement units commonly used in the United States and most U.S. territories, since being standardized and adopted in 1832. The United States customary system developed from English units that were in use in the British Empire before the U.S. became an independent country. The United Kingdom's system of measures was overhauled in 1824 to create the imperial system, which was officially adopted in 1826, changing the definitions of some of its units. Consequently, while many U.S. units are essentially similar to their imperial counterparts, there are significant differences between the systems.
A viscometer is an instrument used to measure the viscosity of a fluid. For liquids with viscosities which vary with flow conditions, an instrument called a rheometer is used. Thus, a rheometer can be considered as a special type of viscometer. Viscometers can measure only constant viscosity, that is, viscosity that does not change with flow conditions.
In recipes, quantities of ingredients may be specified by mass, by volume, or by count.
Paregoric, or camphorated tincture of opium, also known as tinctura opii camphorata, is a traditional patent medicine known for its antidiarrheal, antitussive, and analgesic properties.
A pipette is a type of laboratory tool commonly used in chemistry and biology to transport a measured volume of liquid, often as a media dispenser. Pipettes come in several designs for various purposes with differing levels of accuracy and precision, from single piece glass pipettes to more complex adjustable or electronic pipettes. Many pipette types work by creating a partial vacuum above the liquid-holding chamber and selectively releasing this vacuum to draw up and dispense liquid. Measurement accuracy varies greatly depending on the instrument.
The minim is a unit of volume in both the imperial and U.S. customary systems of measurement. Specifically it is 1⁄60 of a fluid drachm or 1⁄480 of a fluid ounce.
Pitch is a viscoelastic polymer which can be natural or manufactured, derived from petroleum, coal tar, or plants. Pitch produced from petroleum may be called bitumen or asphalt, while plant-derived pitch, a resin, is known as rosin in its solid form. Tar is sometimes used interchangeably with pitch, but generally refers to a more liquid substance derived from coal production, including coal tar, or from plants, as in pine tar.
The dram is a unit of mass in the avoirdupois system, and both a unit of mass and a unit of volume in the apothecaries' system. It was originally both a coin and a weight in ancient Greece. The unit of volume is more correctly called a fluid dram, fluid drachm, fluidram or fluidrachm.
English units were the units of measurement used in England up to 1826, which evolved as a combination of the Anglo-Saxon and Roman systems of units. Various standards have applied to English units at different times, in different places, and for different applications.
Both the British imperial measurement system and United States customary systems of measurement derive from earlier English unit systems used prior to 1824 that were the result of a combination of the local Anglo-Saxon units inherited from Germanic tribes and Roman units.
An eye dropper, also called Pasteur pipette or simply dropper, is a device used to transfer small quantities of liquids. They are used in the laboratory and also to dispense small amounts of liquid medicines. A very common use was to dispense eye drops into the eye. The commonly recognized form is a glass tube tapered to a narrow point and fitted with a rubber bulb at the top, although many styles of both plastic and glass droppers exist. The combination of the pipette and rubber bulb has also been referred to as a teat pipette. The Pasteur pipette name is from the French scientist Louis Pasteur, who used a variant of them extensively during his research. In the past, there was no equipment to transfer a chemical solution without exposing it to the external environment. The hygiene and purity of chemical compounds is necessary for the expected result of each experiment. The eye dropper, both glass and plastic types, can be sterilized and plugged with a rubber bulb at the open end of the pipette preventing any contamination from the atmosphere. Generally, they are considered cheap enough to be disposable, however, so long as the glass point is not chipped, the eye dropper may be washed and reused indefinitely.
The viscosity of a fluid is a measure of its resistance to deformation at a given rate. For liquids, it corresponds to the informal concept of "thickness": for example, syrup has a higher viscosity than water. Viscosity is defined scientifically as a force multiplied by a time divided by an area. Thus its SI units are newton-seconds per square meter, or pascal-seconds.
In fluid mechanics, the Reynolds number is a dimensionless quantity that helps predict fluid flow patterns in different situations by measuring the ratio between inertial and viscous forces. At low Reynolds numbers, flows tend to be dominated by laminar (sheet-like) flow, while at high Reynolds numbers, flows tend to be turbulent. The turbulence results from differences in the fluid's speed and direction, which may sometimes intersect or even move counter to the overall direction of the flow. These eddy currents begin to churn the flow, using up energy in the process, which for liquids increases the chances of cavitation.
Alcoholic spirits measures are instruments designed to measure exact amounts or shots of alcoholic spirits.
Piston-driven air displacement pipettes are a type of micropipette, which are tools to handle volumes of liquid in the microliter scale. They are more commonly used in biology and biochemistry, and less commonly in chemistry; the equipment is susceptible to damage from many organic solvents.
A drip chamber is a device used to allow gas to rise out from a fluid so that it is not passed downstream. It is commonly employed in delivery systems of intravenous therapy and acts to prevent air embolism.
Reagent bottles, also known as media bottles or graduated bottles, are containers made of glass, plastic, borosilicate or related substances, and topped by special caps or stoppers. They are intended to contain chemicals in liquid or powder form for laboratories and stored in cabinets or on shelves. Some reagent bottles are tinted amber (actinic), brown or red to protect light-sensitive chemical compounds from visible light, ultraviolet and infrared radiation which may alter them; other bottles are tinted blue or uranium green for decorative purposes -mostly vintage apothecary sets, from centuries in which a doctor or apothecary was a prominent figure. The bottles are called "graduated" when they have marks on the sides indicating the approximate amount of liquid at a given level within the container. A reagent bottle is a type of laboratory glassware. The term "reagent" refers to a substance that is part of a chemical reaction, and "media" is the plural form of "medium" which refers to the liquid or gas which a reaction happens within, or is a processing chemical tool such as a flux.
A spray is a dynamic collection of drops dispersed in a gas. The process of forming a spray is known as atomization. A spray nozzle is the device used to generate a spray. The two main uses of sprays are to distribute material over a cross-section and to generate liquid surface area. There are thousands of applications in which sprays allow material to be used most efficiently. The spray characteristics required must be understood in order to select the most appropriate technology, optimal device and size.
A graduated pipette is a pipette with its volume, in increments, marked along the tube. It is used to accurately measure and transfer a volume of liquid from one container to another. It is made from plastic or glass tubes and has a tapered tip. Along the body of the tube are graduation markings indicating volume from the tip to that point. A small pipette allows for more precise measurement of fluids; a larger pipette can be used to measure volumes when the accuracy of the measurement is less critical. Accordingly, pipettes vary in volume, with most measuring between 0 and 25.0 millilitres.