Zidovudine (ZDV), also known as azidothymidine (AZT), was the first antiretroviral medication used to prevent and treat HIV/AIDS. It is generally recommended for use in combination with other antiretrovirals. It may be used to prevent mother-to-child spread during birth or after a needlestick injury or other potential exposure. It is sold both by itself and together as lamivudine/zidovudine and abacavir/lamivudine/zidovudine. It can be used by mouth or by slow injection into a vein.
The United States President's Emergency Plan For AIDS Relief (PEPFAR) is a United States governmental initiative to address the global HIV/AIDS epidemic and help save the lives of those suffering from the disease. Launched by U.S. President George W. Bush in 2003, as of May 2020, PEPFAR has provided about $90 billion in cumulative funding for HIV/AIDS treatment, prevention, and research since its inception, making it the largest global health program focused on a single disease in history until the COVID-19 pandemic. PEPFAR is implemented by a combination of U.S. government agencies in over 50 countries and overseen by the Global AIDS Coordinator at the United States Department of State. As of 2023, PEPFAR has saved over 25 million lives, primarily in sub-Saharan Africa.
Elizabeth Glaser was an American AIDS activist and child advocate married to actor and director Paul Michael Glaser. She contracted HIV very early in the AIDS epidemic after receiving an HIV-contaminated blood transfusion in 1981 while giving birth. Like other HIV-infected mothers, Glaser unknowingly passed the virus to her infant daughter, Ariel, who died in 1988.
HIV/AIDS in India is an epidemic. The National AIDS Control Organisation (NACO) estimated that 2.14 million people lived with HIV/AIDS in India in 2017. Despite being home to the world's third-largest population of persons with HIV/AIDS, the AIDS prevalence rate in India is lower than that of many other countries. In 2016, India's AIDS prevalence rate stood at approximately 0.30%—the 80th highest in the world. Treatment of HIV/AIDS is via a combination of antiretroviral drugs and education programs to help people avoid infection.
Mozambique is a country particularly hard-hit by the HIV/AIDS epidemic. According to 2008 UNAIDS estimates, this southeast African nation has the 8th highest HIV rate in the world. With 1,600,000 Mozambicans living with HIV, 990,000 of which are women and children, Mozambique's government realizes that much work must be done to eradicate this infectious disease. To reduce HIV/AIDS within the country, Mozambique has partnered with numerous global organizations to provide its citizens with augmented access to antiretroviral therapy and prevention techniques, such as condom use. A surge toward the treatment and prevention of HIV/AIDS in women and children has additionally aided in Mozambique's aim to fulfill its Millennium Development Goals (MDGs). Nevertheless, HIV/AIDS has made a drastic impact on Mozambique; individual risk behaviors are still greatly influenced by social norms, and much still needs to be done to address the epidemic and provide care and treatment to those in need.
HIV and AIDS is a major public health issue in Zimbabwe. The country is reported to hold one of the largest recorded numbers of cases in Sub-Saharan Africa. According to reports, the virus has been present in the country since roughly 40 years ago. However, evidence suggests that the spread of the virus may have occurred earlier. In recent years, the government has agreed to take action and implement treatment target strategies in order to address the prevalence of cases in the epidemic. Notable progress has been made as increasingly more individuals are being made aware of their HIV/AIDS status, receiving treatment, and reporting high rates of viral suppression. As a result of this, country progress reports show that the epidemic is on the decline and is beginning to reach a plateau. International organizations and the national government have connected this impact to the result of increased condom usage in the population, a reduced number of sexual partners, as well as an increased knowledge and support system through successful implementation of treatment strategies by the government. Vulnerable populations disproportionately impacted by HIV/AIDS in Zimbabwe include women and children, sex workers, and the LGBTQ+ population.
Cases of HIV/AIDS in Peru are considered to have reached the level of a concentrated epidemic.
The first HIV/AIDS case in Malaysia made its debut in 1986. Since then, HIV/AIDS has become one of the country's most serious health and development challenges. As of 2020, the Ministry of Health estimated that 87 per cent of an estimated 92,063 people living with HIV (PLHIV) in Malaysia were aware of their status, 58 per cent of reported PLHIV received antiretroviral therapy, and 85 per cent of those on antiretroviral treatment became virally suppressed. Despite making positive progress, Malaysia still fell short of meeting the global 2020 HIV goals of 90-90-90, with a scorecard of 87-58-85.
Anita Rachlis, M.D. is a Canadian HIV/AIDS researcher and is the principal author of the HIV treatment guidelines in Canada. She is an associate scientist at the Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, in Toronto, Ontario, Canada.
Michael Stuart Gottlieb is an American physician and immunologist known for his 1981 identification of acquired immune deficiency syndrome (AIDS) as a new disease, and for his HIV/AIDS research, HIV/AIDS activism, and philanthropic efforts associated with HIV/AIDS treatment.
HIV prevention refers to practices that aim to prevent the spread of the human immunodeficiency virus (HIV). HIV prevention practices may be undertaken by individuals to protect their own health and the health of those in their community, or may be instituted by governments and community-based organizations as public health policies.
Arthur J. Ammann was an American pediatric immunologist and advocate known for his research on HIV transmission, discovering in utero transmission and the risk of contaminated transfusions and blood products, and his role in the development of the first successful vaccine to prevent pneumococcal infection in 1977. He founded Global Strategies for HIV Prevention and was Clinical Professor of Pediatrics at the UCSF Medical Center.
Deborah Persaud is a Guyanese-born American virologist who primarily works on HIV/AIDS at Johns Hopkins Children's Center.
Breastfeeding by HIV-infected mothers is the practice of breastfeeding of HIV-infected mothers and include those who may want to or are currently breastfeeding. HIV can be transmitted to the infant through breastfeeding. The risk of transmission varies and depends on the viral load in the mother's milk. An infant can be infected with HIV throughout the duration of the pregnancy or during childbirth (intrapartum).
The Catholic Medical Mission Board (CMMB) is an international, faith-based NGO, providing long-term, co-operative medical and development aid to communities affected by poverty and healthcare issues. It was established in 1912 and officially registered in 1928. CMMB is headquartered in New York City, USA, and currently has country offices in Haiti, Kenya, Peru, South Sudan, and Zambia.
Janet L. Mitchell was an American physician known for her advances in perinatal HIV/AIDS treatment. During the early days of the AIDS epidemic in the U.S. Mitchell developed protocols for health treatment of pregnant women who were HIV positive or at risk for developing AIDS. She advocated against mandatory testing and testifying before Congress, she advocated in favor of an inclusive approach to health care and social services. One of her innovations derived from a study that saw a 70% decrease in HIV transmission to babies when AZT was administered to their mothers during the pregnancy.
Mark W. Kline is an American pediatrician and infectious diseases specialist who currently serves as the Physician-in-Chief, Senior Vice President and Chief Medical Officer at Children's Hospital New Orleans and Professor of Pediatrics at the Tulane University School of Medicine and LSU Health New Orleans. Kline is known for his life-long work in building programs for children with HIV/AIDS all over the world.
Etienne Karita is a Rwandan scientist who has been researching HIV/AIDS in Rwanda since the mid-1980s. He has held numerous leadership positions in different organizations that are working to control HIV in Rwanda. Some of his work is concentrated on preventing mother to child transmission of HIV and in collaboration with Projet San Francisco, he has studied HIV in discordant couples.
Josephine Nabukenya is a Ugandan HIV/AIDS activist who is also living with HIV/AIDS. She serves as a Stephen Lewis Foundation Youth program coordinator at Makerere University Johns Hopkins University (MUJHU). She was awarded the Queen’s Young Leader Award in 2016 for her advocacy work. She is also an Ambassador at Elizabeth Glaser Pediatric AIDS Foundation (EGPAF)'s Ariel Club. She is one of the young leaders who grew from being timid to a resilient and powerful young leader who encourages other children to live positively and take their pills.
Catherine Wilfert was an American pediatrician specializing in infectious diseases. She became a professor at Duke University School of Medicine and known internationally for her work in pediatric HIV prevention. After 1993, using zidovudine during pregnancy led to an estimated reduction of mother-to-infant transmission of HIV in the United States by 75 percent and a 47 percent decrease in new HIV infections globally.
