Eva-Maria Mandelkow

Last updated
Eva-Maria Mandelkow
CitizenshipGermany
Known for Alzheimer's disease
SpouseEckhard Mandelkow
Awards Metlife Foundation Award for Medical Research in Alzheimer's Disease (2009)
Potamkin Prize (2011)
Alz. Assoc. Lifetime Award (2013)
Scientific career
Fields neurology
Institutions DZNE, Bonn (2011-)
MPASMB, Hamburg

Eva-Maria Mandelkow is a German neuroscientist and Alzheimer's disease researcher at the German Center for Neurodegenerative Diseases (DZNE), Bonn. [1]

Contents

Biography

Eva-Maria Mandelkow studied medicine in Hamburg and Heidelberg, qualifying in 1968. After three years of medical internships, she began doctoral studies at the Max Planck Institute for Medical Research, Heidelberg, investigating the enzyme kinetics of the motor protein myosin. She graduated in 1973 with a Ph.D. in biochemistry, then undertook postdoctoral training at Brandeis University in Massachusetts (1974-1975) researching cytoskeletal proteins. She continued to work in this area after returning to the Max Planck Institute in Heidelberg as a staff scientist (1977-1985). In 1986 she moved with her husband and colleague, Eckhard Mandelkow  [ de ], to lead research teams at the Max Planck Unit for Structural Molecular Biology  [ de ] (MPASMB) located within the DESY facility, Hamburg. [1] Since 2011 Eva-Maria and Eckhard Mandelow have led closely aligned research teams at DZNE.

Awards

The Mandelkows' best-known work is on the role of tau protein in the development of Alzheimer's disease, which they have been studying since 1989. [2] Mandelkow won the Hans and Ilse Breuer Foundation Alzheimer's Research Award in 2007. [3] Eva-Maria and her husband were jointly awarded the Metlife Foundation Award for Medical Research in Alzheimer's Disease in 2009, [2] the Potamkin Prize of the American Academy of Neurology in 2011 (the goal of the prize is to help attract the best medical minds and most dedicated scientists in the world to the field of dementia research), [4] and a Lifetime Achievement Award from the Alzheimer's Association in 2013. [5]

Related Research Articles

<span class="mw-page-title-main">Fred Gage</span> American geneticist

Fred "Rusty" Gage is an American geneticist known for his discovery of stem cells in the adult human brain. Gage is a former president (2018–2023) of the Salk Institute for Biological Studies, where he holds the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Disease and works in the Laboratory of Genetics.

<span class="mw-page-title-main">Leibniz Prize</span> German research award

The Gottfried Wilhelm Leibniz Prize, or Leibniz Prize, is awarded by the German Research Foundation to "exceptional scientists and academics for their outstanding achievements in the field of research". Since 1986, up to ten prizes have been awarded annually to individuals or research groups working at a research institution in Germany or at a German research institution abroad. It is considered the most important research award in Germany.

Christine Van Broeckhoven is a Belgian molecular biologist and professor in Molecular genetics at the University of Antwerp. She is also leading the VIB Department of Molecular Genetics, University of Antwerp of the Flanders Institute for Biotechnology (VIB). Christine Van Broeckhoven does research on Alzheimer dementia, bipolar mental disorders and other neurological diseases. Since 1983 she has had her own laboratory for molecular genetics at the University of Antwerp, and since 2005 is focussing her research on neurodegenerative brain diseases. She is an associate editor of the scientific journal Genes, Brain and Behavior.

The Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases was established in 1988 and is sponsored by the American Academy of Neurology. The prize is funded through the philanthropy of the Potamkin Foundation. The prize is awarded for achievements on emerging areas of research in Pick's disease, Alzheimer's disease and other dementias.

Sir John Anthony Hardy is a human geneticist and molecular biologist at the Reta Lila Weston Institute of Neurological Studies at University College London with research interests in neurological diseases.

Bart De Strooper is a Belgian molecular biologist and professor at Vlaams Instituut voor Biotechnologie and KU Leuven and the UK Dementia Research Institute and University College London, UK. De Strooper's research seeks to translate genetic data into the identification and treatment of neurodegenerative diseases and treatments. interest are the secretases, proteases which cleave the amyloid precursor protein (APP), resulting in amyloid peptides.

Christian Haass is a German biochemist who specializes in metabolic biochemistry and neuroscience.

John Quinn Trojanowski was an American academic research neuroscientist specializing in neurodegeneration. He and his partner, Virginia Man-Yee Lee, MBA, Ph.D., are noted for identifying the roles of three proteins in neurodegenerative diseases: tau in Alzheimer's disease, alpha-synuclein in Parkinson's disease, and TDP-43 in Amyotrophic Lateral Sclerosis (ALS) and frontotemporal degeneration.

Peter Henry St George-Hyslop, OC, FRS, FRSC, FRCPC, is a British and Canadian medical scientist, neurologist and molecular geneticist who is known for his research into neurodegenerative diseases. St George-Hyslop is one of the most cited authors in the field of Alzheimer's disease research. He has identified a number of key genes that are responsible for nerve cell degeneration and early-onset forms of Alzheimer's disease. These include the discovery of the presenilins, Nicastrin, and SORL1 genes. Presenilin mutations are the most common cause of familial Alzheimer's disease. St George-Hyslop also co-led the discovery of the gene for the amyloid precursor protein.

<span class="mw-page-title-main">Thomas C. Südhof</span> German-American biochemist

Thomas Christian Südhof, ForMemRS, is a German-American biochemist known for his study of synaptic transmission. Currently, he is a professor in the school of medicine in the department of molecular and cellular physiology, and by courtesy in neurology, and in psychiatry and behavioral sciences at Stanford University.

Peter Davies was a Welsh scientist and active researcher. He was the head and director of the Litwin-Zucker Research Center for The Study of Alzheimer's disease and memory disorders, associated with the Feinstein Institute for Medical Research in Manhasset, New York, US.

<span class="mw-page-title-main">Michel Goedert</span> Luxembourgish-British neuroscientist

Michel Goedert FRS, FMedSci is a Luxembourgish-British neuroscientist and former Head of Neurobiology, at the MRC Laboratory of Molecular Biology.

Magdalena Götz is a German neuroscientist. She is noted for her study of glial cells and holds a chair at Ludwig Maximilian University of Munich's Department of Physiology. She is involved in the field of adult neurogenesis. Götz discovered that glial cells are neural stem cells in the developing mammalian brain. Current investigations study the mechanisms involved in determining how adult neural stem cells are specified. Götz current work focuses on refining ways to reprogram glial cells into neurons in organisms with traumatic brain injury. The German Stem Cell Network published an interview with Götz in 2015 explaining her research field.

Bradley Theodore Hyman is currently John B. Penney, Jr. Professor of Neurology at Harvard Medical School and Director of the Massachusetts Alzheimer Disease Research Center and Memory Disorder Unit at Massachusetts General Hospital. He was educated at Northwestern University and the University of Iowa. He was awarded the Metlife Foundation Award for Medical Research in Alzheimer's Disease in 2001 and the Potamkin Prize in 2006, together with Karen Duff and Karen Ashe.

Chester Mathis is an American chemist who is currently the Distinguished Professor of Radiology at University of Pittsburgh and holds the UPMC Endowed Chair of PET Research.

Konrad Beyreuther is a German molecular biologist and chemist known for his work on neurodegenerative diseases.

Colin Louis MastersMD is an Australian neuropathologist who researches Alzheimer's disease and other neurodegenerative disorders. He is laureate professor of pathology at the University of Melbourne.

The Metlife Foundation Award for Medical Research in Alzheimer's Disease were awarded annually from 1986 to 2016 to recognize scientific contributions toward a better understanding of the underlying causes, prevention, and treatments of Alzheimer's disease. The awards were endowed by the Metlife Foundation and administered by The American Federation for Aging Research.

Mathias Jucker is a Swiss neuroscientist, Professor, and a Director at the Hertie Institute for Clinical Brain Research of the University of Tübingen. He is also a group leader at the German Center for Neurodegenerative Diseases in Tübingen. Jucker is known for his research on the basic biologic mechanisms underlying brain aging and Alzheimer’s disease.

Dennis J. Selkoe is an American physician (neurologist) known for his research into the molecular basis of Alzheimer's disease. In 1985 he became Co-Director of the Center for Neurological Diseases and from 1990, Vincent and Stella Coates Professor of Neurological Diseases at Harvard Medical School. He is also a Fellow of the AAAS and a member of the National Academy of Medicine.

References

  1. 1 2 "Curriculum vitae". DZNE. Retrieved 11 October 2018.
  2. 1 2 "2016 Metlife Foundation Awards for Medical Research in Alzheimer's Disease" (PDF). MetLife Foundation. 2016. Retrieved 11 October 2018.
  3. "Hans und Ilse Breuer-Stiftung: Preisträger" [Hans and Ilse Breuer Foundation: Award Winners]. Hans and Ilse Breuer Foundation (in German). Retrieved 1 October 2018.
  4. "Three Researchers Awarded $100,000 Potamkin Prize from AAN". Official AAN Home Page. Archived from the original on 14 April 2015. Retrieved 11 October 2018.
  5. "Pioneers in Alzheimer's research: Research couple honored for its lifetime achievement". EurekAlert!. 16 July 2013. Retrieved 11 October 2018.