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Fulhold Pharma Limited (formerly Fulhold Pharma plc) [1] is a British pharmaceutical company. It produces the patented CarboHydrate Derived Fulvic Acid (CHD-FA) and formulations containing this product.
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Fulhold Pharma Limited (formerly Fulhold Pharma plc) [1] is a British pharmaceutical company. It produces the patented CarboHydrate Derived Fulvic Acid (CHD-FA) and formulations containing this product.
Fulhold Pharma was incorporated in February 2014. [2] The main reason was to consolidate its predecessor, Fulhold Ltd (BVI) and its other operations, and to create a vehicle for raising further funding.
Fulhold Pharma’s Intellectual Property is a biological platform technology with a wide range of applications in human and animal health. This was developed over a period of 10 years prior to the incorporation of Fulhold Pharma. The molecule that is at the heart of this biological platform is CarboHydrate Derived Fulvic Acid (CHD-FA).
CHD-FA is a broad-spectrum anti-microbial/anti-inflammatory compound active on drug resistant Gram positive, Gram negative, and fungal pathogens that can be both ingested and topically applied. CHD-FA in combination with lower levels of antibiotics has demonstrated the same efficacy as higher levels of the same antibiotics alone.
The company's shares were admitted for trading on the GXG Market on 14 April 2015. Trading was suspended on 3 June 2015 at a price of 1.40 GBP and a market capitalisation of $108.9 million. [2] [3] [4] According to financial media group, MoneyWeb, the trading suspension was due to "fallout from the investigations into companies with links to Belvedere Management." [2] A June 2015 article in BizNews described Belvedere Management as one of "four dubious British shell companies." [5] Shareholders include founding director David Cosgrove, who resigned in March 2015, as well as Dualstar Capital Private Equity Fund and the Alexander High Yield Fund. [2] A regulatory investigation by the Guernsey Financial Services Commission (GFSC) downgraded these original accusations to technical administrative breaches and ended in 2017 without any action being taken. A parallel investigation in Mauritius is currently facing legal challenge. [6]
In August 2015, the company acquired Ful Hold Limited [2] which had worked on a topical drug for wounds with Euprotec in 2013. [7]
Fulhold Pharma is a British pharmaceutical company with its manufacturing plant located in South Africa. [2] Fulhold Pharma's Intellectual Property is a biological molecule, CarboHydrate Derived Fulvic Acid (CHD-FA) and is manufactured as an ingredient in medications. [8]
Research into CHD-FA's broad-spectrum anti-microbial/anti-inflammatory agency on drug-resistant Gram positive, Gram negative, and fungal pathogens through ingestion and topical application includes:
A 2015 company press release listed David Squire as chief executive officer and chairman and Stephen Leivers as founder and chief scientific officer. [12]
An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of such infections. They may either kill or inhibit the growth of bacteria. A limited number of antibiotics also possess antiprotozoal activity. Antibiotics are not effective against viruses such as the common cold or influenza; drugs which inhibit growth of viruses are termed antiviral drugs or antivirals rather than antibiotics. They are also not effective against fungi; drugs which inhibit growth of fungi are called antifungal drugs.
A broad-spectrum antibiotic is an antibiotic that acts on the two major bacterial groups, Gram-positive and Gram-negative, or any antibiotic that acts against a wide range of disease-causing bacteria. These medications are used when a bacterial infection is suspected but the group of bacteria is unknown or when infection with multiple groups of bacteria is suspected. This is in contrast to a narrow-spectrum antibiotic, which is effective against only a specific group of bacteria. Although powerful, broad-spectrum antibiotics pose specific risks, particularly the disruption of native, normal bacteria and the development of antimicrobial resistance. An example of a commonly used broad-spectrum antibiotic is ampicillin.
An antifungal medication, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others. Such drugs are usually obtained by a doctor's prescription, but a few are available over the counter (OTC). The evolution of antifungal resistance is a growing threat to health globally.
Fusidic acid, sold under the brand names Fucidin among others, is an antibiotic that is often used topically in creams or ointments and eyedrops but may also be given systemically as tablets or injections.
As of October 2008, the global problem of advancing antimicrobial resistance has led to a renewed interest in its use.
Neomycin/polymyxin B/bacitracin, also known as triple antibiotic ointment, is an antibiotic medication used to reduce the risk of infections following minor skin injuries. It contains the three antibiotics neomycin, polymyxin B, and bacitracin. It is for topical use.
Antimicrobial peptides (AMPs), also called host defence peptides (HDPs) are part of the innate immune response found among all classes of life. Fundamental differences exist between prokaryotic and eukaryotic cells that may represent targets for antimicrobial peptides. These peptides are potent, broad spectrum antimicrobials which demonstrate potential as novel therapeutic agents. Antimicrobial peptides have been demonstrated to kill Gram negative and Gram positive bacteria, enveloped viruses, fungi and even transformed or cancerous cells. Unlike the majority of conventional antibiotics it appears that antimicrobial peptides frequently destabilize biological membranes, can form transmembrane channels, and may also have the ability to enhance immunity by functioning as immunomodulators.
A biopesticide is a biological substance or organism that damages, kills, or repels organisms seen as pests. Biological pest management intervention involves predatory, parasitic, or chemical relationships.
Betamethasone dipropionate is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities. It is applied as a topical cream, ointment, lotion or gel (Diprolene) to treat itching and other skin conditions such as eczema. Minor side effects include dry skin and mild, temporary stinging when applied. Betamethasone dipropionate is a "super high potency" corticosteroid used to treat inflammatory skin conditions such as dermatitis, eczema and psoriasis. It is a synthetic analog of the adrenal corticosteroids. Although its exact mechanism of action is not known, it is effective when applied topically to cortico-responsive inflammatory dermatoses. It is available as a generic medication.
Ceragenix Pharmaceuticals, Inc. is a biopharmaceutical company headquartered in Denver, Colorado that develops prescription therapies based on a platform of proprietary surface active technologies—skin Barrier Repair Technology (BRT) and Cerageninis, a new class of broad spectrum anti-infectives. The company discovers, develops and commercializes anti-infective drugs based on its proprietary class of compounds, Ceragenins. Active against a range of gram positive and gram negative bacteria, these agents are being developed as anti-infective medical device coatings and as therapeutics for antibiotic-resistant organisms.
Marbofloxacin is a carboxylic acid derivative third generation fluoroquinolone antibiotic. It is used in veterinary medicine under the brand names Marbocyl, Forcyl, Marbo vet and Zeniquin. A formulation of marbofloxacin combined with clotrimazole and dexamethasone is available under the name Aurizon.
Nadifloxacin is a topical fluoroquinolone antibiotic for the treatment of acne vulgaris. It is also used to treat bacterial skin infections.
Iclaprim is an antibiotic drug candidate that is active against Gram positive organisms. It is administered intravenously.
Taurolidine is an antimicrobial that is used to prevent infections in catheters. Side effects and the induction of bacterial resistance is uncommon. It is also being studied as a treatment for cancer.
Cephalosporins are a broad class of bactericidal antibiotics that include the β-lactam ring and share a structural similarity and mechanism of action with other β-lactam antibiotics. The cephalosporins have the ability to kill bacteria by inhibiting essential steps in the bacterial cell wall synthesis which in the end results in osmotic lysis and death of the bacterial cell. Cephalosporins are widely used antibiotics because of their clinical efficiency and desirable safety profile.
David Dawson Cosgrove is an Irish businessman whose Belvedere Management group claimed to have $16 billion of assets under administration. In 2016 he was barred from serving as an officer of any company regulated by the Mauritius Financial Services Commission (FSC) for a period of 5 years and the funds he managed were liquidated.
Kenneth Jean Georgy Maillard is a Mauritian accountant who is one of the principals of the Belvedere Management group.
William Francis Redford is a British businessman. He is the chief executive, since October 2014, of Eligere Investments plc, a company formerly traded on the GXG Market in Denmark.
Eligere Investments plc was a company that traded in environmental services such as the generation, provision and distribution of voluntary carbon offsets. The company received a warning from the UK's Financial Conduct Authority that it may be providing financial services or products in the UK without authorisation. The company became insolvent in 2017 and was liquidated in April 2020.
A proteolipid is a protein covalently linked to lipid molecules, which can be fatty acids, isoprenoids or sterols. The process of such a linkage is known as protein lipidation, and falls into the wider category of acylation and post-translational modification. Proteolipids are abundant in brain tissue, and are also present in many other animal and plant tissues. They include ghrelin, a peptide hormone associated with feeding. Many proteolipids are composed of proteins covalenently bound to fatty acid chains, often granting them an interface for interacting with biological membranes. They are not to be confused with lipoproteins, a kind of spherical assembly made up of many molecules of lipids and some apolipoproteins.
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