A mouse is a small rodent. Characteristically, mice are known to have a pointed snout, small rounded ears, a body-length scaly tail, and a high breeding rate. The best known mouse species is the common house mouse. Mice are also popular as pets. In some places, certain kinds of field mice are locally common. They are known to invade homes for food and shelter.
The southern platyfish, common platy, or moonfish is a species of freshwater fish in family Poeciliidae of order Cyprinodontiformes. A live-bearer, it is closely related to the green swordtail and can interbreed with it. It is native to an area of North and Central America stretching from Veracruz, Mexico, to northern Belize.
Inbred strains are individuals of a particular species which are nearly identical to each other in genotype due to long inbreeding. A strain is inbred when it has undergone at least 20 generations of brother x sister or offspring x parent mating, at which point at least 98.6% of the loci in an individual of the strain will be homozygous, and each individual can be treated effectively as clones. Some inbred strains have been bred for over 150 generations, leaving individuals in the population to be isogenic in nature. Inbred strains of animals are frequently used in laboratories for experiments where for the reproducibility of conclusions all the test animals should be as similar as possible. However, for some experiments, genetic diversity in the test population may be desired. Thus outbred strains of most laboratory animals are also available, where an outbred strain is a strain of an organism that is effectively wildtype in nature, where there is as little inbreeding as possible.
ENU, also known as N-ethyl-N-nitrosourea (chemical formula C3H7N3O2), is a highly potent mutagen. For a given gene in mice, ENU can induce 1 new mutation in every 700 loci. It is also toxic at high doses.
A microbiological culture, or microbial culture, is a method of multiplying microbial organisms by letting them reproduce in predetermined culture medium under controlled laboratory conditions. Microbial cultures are foundational and basic diagnostic methods used as research tools in molecular biology.
Xiphophorus is a genus of euryhaline and freshwater fishes in the family Poeciliidae of order Cyprinodontiformes, native to Mexico and northern Central America. The many Xiphophorus species are all known as platyfish and swordtails. Platyfish formerly were classified in another genus, Platypoecilia, which is now obsolete. The type species is X. hellerii, the green swordtail. Like most other new world Poeciliids, platies and swordtails are live-bearers that use internal fertilization and give birth to live young instead of laying eggs like the bulk of the world's fishes. The name Xiphophorus derives from the Greek words ξίφος (dagger) and φόρος (bearer), referring to the gonopodium on the males. All are relatively small fishes, which reach a maximum length of 3.5–16 cm (1.4–6.3 in) depending on the exact species involved.
The laboratory mouse or lab mouse is a small mammal of the order Rodentia which is bred and used for scientific research or feeders for certain pets. Laboratory mice are usually of the species Mus musculus. They are the most commonly used mammalian research model and are used for research in genetics, physiology, psychology, medicine and other scientific disciplines. Mice belong to the Euarchontoglires clade, which includes humans. This close relationship, the associated high homology with humans, their ease of maintenance and handling, and their high reproduction rate, make mice particularly suitable models for human-oriented research. The laboratory mouse genome has been sequenced and many mouse genes have human homologues. Lab mice sold at pet stores for snake food can also be kept as pets.
In biology, a strain is a genetic variant, a subtype or a culture within a biological species. Strains are often seen as inherently artificial concepts, characterized by a specific intent for genetic isolation. This is most easily observed in microbiology where strains are derived from a single cell colony and are typically quarantined by the physical constraints of a Petri dish. Strains are also commonly referred to within virology, botany, and with rodents used in experimental studies.
Laboratory rats or lab rats are strains of the subspecies Rattus norvegicus domestica which are bred and kept for scientific research. While less commonly used for research than laboratory mice, rats have served as an important animal model for research in psychology and biomedical science.
The Jackson Laboratory is an independent, non-profit biomedical research institution which was founded by Clarence Cook Little in 1929. It employs over 3,000 employees in Bar Harbor, Maine; Sacramento, California; Farmington, Connecticut; Shanghai, China; and Yokohama, Japan. The institution is a National Cancer Institute-designated Cancer Center and has NIH Centers of Excellence in aging and systems genetics. The stated mission of The Jackson Laboratory is "to discover the genetic basis for preventing, treating and curing human diseases, and to enable research and education for the global biomedical community."
Forbidden World, originally titled Mutant, is a 1982 American science fiction-horror film. The screenplay was written by Tim Curnen, from a screenstory by R.J. Robertson and Jim Wynorski. It was co-edited and directed by Allan Holzman, who had edited Battle Beyond the Stars two years earlier. The cast includes Jesse Vint, Dawn Dunlap, June Chadwick, Linden Chiles, Fox Harris and Michael Bowen. Forbidden World has also been released under the titles Mutant and Subject 20.
C57BL/6, often referred to as "C57 black 6", "B6", "C57" or "black 6", is a common inbred strain of laboratory mouse.
BALB/c is an albino, laboratory-bred strain of the house mouse from which a number of common substrains are derived. Now over 200 generations from New York in 1920, BALB/c mice are distributed globally, and are among the most widely used inbred strains used in animal experimentation.
The history of model organisms began with the idea that certain organisms can be studied and used to gain knowledge of other organisms or as a control (ideal) for other organisms of the same species. Model organisms offer standards that serve as the authorized basis for comparison of other organisms. Model organisms are made standard by limiting genetic variance, creating, hopefully, this broad applicability to other organisms.
Established in 1960, the Fungal Genetics Stock Center is the main open repository for genetically characterized fungi. The FGSC is a member of the World Federation for Culture Collections and is a leading collection in the US Culture Collection Network Research Coordination Network.
Myron Gordon was an American biologist and geneticist and became an expert on platy fish Xiphophorus while using them for his pioneering cancer research, starting in the late 1920s. Early papers were published while still a graduate student at Cornell University, but he is best known for his research at New York University and the New York Zoological Society.
The northern platyfish is a small, endangered species of fish in the family Poeciliidae. It is endemic to the vicinity of Cuatro Ciénegas in the Mexican state of Coahuila. It is restricted to hot-spring heated ditches and marshes of the Laguna Santa Tecla. Its native water is shallow and vegetation-choked, with very stable temperatures that generally are around 27–30 °C (81–86 °F), although captive studies show the species also can live in slightly colder water.
A genetically modified mouse or genetically engineered mouse model (GEMM) is a mouse that has had its genome altered through the use of genetic engineering techniques. Genetically modified mice are commonly used for research or as animal models of human diseases and are also used for research on genes. Together with patient-derived xenografts (PDXs), GEMMs are the most common in vivo models in cancer research. Both approaches are considered complementary and may be used to recapitulate different aspects of disease. GEMMs are also of great interest for drug development, as they facilitate target validation and the study of response, resistance, toxicity and pharmacodynamics.
A knockout mouse, or knock-out mouse, is a genetically modified mouse in which researchers have inactivated, or "knocked out", an existing gene by replacing it or disrupting it with an artificial piece of DNA. They are important animal models for studying the role of genes which have been sequenced but whose functions have not been determined. By causing a specific gene to be inactive in the mouse, and observing any differences from normal behaviour or physiology, researchers can infer its probable function.
The Geisenheim Yeast Breeding Center was founded in 1894 and is located in the town of Geisenheim, in Germany's Rheingau.
