George John Romanes (anatomist)

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George John Romanes
George Stuffy.jpg
Romanes in 1984
Born2 December 1916
Edinburgh
Died9 April 2014
Isle of Skye
NationalityScottish
TitleProfessor of Anatomy
AwardsC.B.E, F.R.S.Ed., B.A., Ph.D., M.B., ChB., D.Sc.(h.c.), F.R.C.S.Ed., F.R.S.E., H.R.S.A.

George John Romanes was an anatomist. Born in Edinburgh in 1916, he received his education at the Edinburgh Academy, the University of Cambridge, and the University of Edinburgh. [1]

Contents

Career

At Cambridge, Romanes studied for the Natural Sciences Tripos, graduating with a B.A. in 1938. In 1941, he returned to Edinburgh to finish the clinical part of his medical course and graduated with an M.B., Ch.B. in 1944. He then returned to Cambridge for two years, as a Beit Memorial Fellow for Medical Research.

In 1942, he completed a Ph.D. in Anatomy during the tenure of a Marmaduke Shield Scholarship (1938–40), and a Demonstratorship in Anatomy.

In 1946, Romanes was appointed Lecturer in Neuro-anatomy in Edinburgh and spent 1949–50 in the Department of Neurology at Columbia University, New York funded by a Commonwealth Fund Fellowship. In 1954, he succeeded J.C. Brash as Professor of Anatomy to become the twelfth holder of the chair since its institution in 1705. In 1956 he was elected a member of the Harveian Society of Edinburgh. [2] In 1962 he was elected a member of the Aesculapian Club. [3]

He retired in 1984, having spent 45 years as a member of the University's staff.

Publications

Romanes published papers demonstrating that the large neurons in the spinal cord that supply individual muscles are clustered together in discrete, nuclei-termed pools that are arranged according to the position of the limb muscles they are programmed to innervate. In a paper published in 1951, Romanes showed that the pools of motor neurons innervating the muscles that act together to control a limb joint are themselves grouped into larger clusters – thus uncovering a positional registration between a motor neuron and its target muscle. Romanes reasoned that “all the higher parts of the central nervous system would be organized in a similar, basic way," a premise that is now gathering experimental support. [4]

His contemporaries used his maps to identify the pathognomonic lesions of motoneurones seen in the polio epidemic that was sweeping the United States of America. Modern workers using transgenic mice have confirmed the genetically-determined location of the motor neuron pools and shown the rest of the spinal cord network, including the connection of the sensory nerves, to be dependent on the positional template described first by Romanes. [5]

Related Research Articles

<span class="mw-page-title-main">Motor neuron</span> Nerve cell sending impulse to muscle

A motor neuron is a neuron whose cell body is located in the motor cortex, brainstem or the spinal cord, and whose axon (fiber) projects to the spinal cord or outside of the spinal cord to directly or indirectly control effector organs, mainly muscles and glands. There are two types of motor neuron – upper motor neurons and lower motor neurons. Axons from upper motor neurons synapse onto interneurons in the spinal cord and occasionally directly onto lower motor neurons. The axons from the lower motor neurons are efferent nerve fibers that carry signals from the spinal cord to the effectors. Types of lower motor neurons are alpha motor neurons, beta motor neurons, and gamma motor neurons.

Pronator quadratus is a square-shaped muscle on the distal forearm that acts to pronate the hand.

<span class="mw-page-title-main">Accessory nerve</span> Cranial nerve XI, for head and shoulder movements

The accessory nerve, also known as the eleventh cranial nerve, cranial nerve XI, or simply CN XI, is a cranial nerve that supplies the sternocleidomastoid and trapezius muscles. It is classified as the eleventh of twelve pairs of cranial nerves because part of it was formerly believed to originate in the brain. The sternocleidomastoid muscle tilts and rotates the head, whereas the trapezius muscle, connecting to the scapula, acts to shrug the shoulder.

<span class="mw-page-title-main">Motor nerve</span> Nerve located in the central nervous system

A motor nerve is a nerve that transmits motor signals from the central nervous system (CNS) to the muscles of the body. This is different from the motor neuron, which includes a cell body and branching of dendrites, while the nerve is made up of a bundle of axons. Motor nerves act as efferent nerves which carry information out from the CNS to muscles, as opposed to afferent nerves, which transfer signals from sensory receptors in the periphery to the CNS. Efferent nerves can also connect to glands or other organs/issues instead of muscles. In addition, there are nerves that serve as both sensory and motor nerves called mixed nerves.

<span class="mw-page-title-main">Grey column</span>

The grey column refers to a somewhat ridge-shaped mass of grey matter in the spinal cord. This presents as three columns: the anterior grey column, the posterior grey column, and the lateral grey column, all of which are visible in cross-section of the spinal cord.

<span class="mw-page-title-main">Reflex arc</span> Neural pathway which controls a reflex

A reflex arc is a neural pathway that controls a reflex. In vertebrates, most sensory neurons do not pass directly into the brain, but synapse in the spinal cord. This allows for faster reflex actions to occur by activating spinal motor neurons without the delay of routing signals through the brain. The brain will receive the input while the reflex is being carried out and the analysis of the signal takes place after the reflex action.

<span class="mw-page-title-main">Pyramidal tracts</span> Include both the corticobulbar tract and the corticospinal tract

The pyramidal tracts include both the corticobulbar tract and the corticospinal tract. These are aggregations of efferent nerve fibers from the upper motor neurons that travel from the cerebral cortex and terminate either in the brainstem (corticobulbar) or spinal cord (corticospinal) and are involved in the control of motor functions of the body.

<span class="mw-page-title-main">Upper motor neuron</span> Neurons in the brain that carry signals to lower motor neurons

Upper motor neurons (UMNs) is a term introduced by William Gowers in 1886. They are found in the cerebral cortex and brainstem and carry information down to activate interneurons and lower motor neurons, which in turn directly signal muscles to contract or relax. UMNs represent the major origin point for voluntary somatic movement.

<span class="mw-page-title-main">Gamma motor neuron</span>

A gamma motor neuron, also called gamma motoneuron, or fusimotor neuron, is a type of lower motor neuron that takes part in the process of muscle contraction, and represents about 30% of (Aγ) fibers going to the muscle. Like alpha motor neurons, their cell bodies are located in the anterior grey column of the spinal cord. They receive input from the reticular formation of the pons in the brainstem. Their axons are smaller than those of the alpha motor neurons, with a diameter of only 5 μm. Unlike the alpha motor neurons, gamma motor neurons do not directly adjust the lengthening or shortening of muscles. However, their role is important in keeping muscle spindles taut, thereby allowing the continued firing of alpha neurons, leading to muscle contraction. These neurons also play a role in adjusting the sensitivity of muscle spindles.

<span class="mw-page-title-main">Vestibulospinal tract</span> Neural tract in the central nervous system

The vestibulospinal tract is a neural tract in the central nervous system. Specifically, it is a component of the extrapyramidal system and is classified as a component of the medial pathway. Like other descending motor pathways, the vestibulospinal fibers of the tract relay information from nuclei to motor neurons. The vestibular nuclei receive information through the vestibulocochlear nerve about changes in the orientation of the head. The nuclei relay motor commands through the vestibulospinal tract. The function of these motor commands is to alter muscle tone, extend, and change the position of the limbs and head with the goal of supporting posture and maintaining balance of the body and head.

<span class="mw-page-title-main">Lateral grey column</span>

The lateral grey column is one of the three grey columns of the spinal cord ; the others being the anterior and posterior grey columns. The lateral grey column is primarily involved with activity in the sympathetic division of the autonomic motor system. It projects to the side as a triangular field in the thoracic and upper lumbar regions of the postero-lateral part of the anterior grey column.

<span class="mw-page-title-main">Anterior corticospinal tract</span>

The anterior corticospinal tract is a small bundle of descending fibers that connect the cerebral cortex to the spinal cord. Descending tracts are pathways by which motor signals are sent from upper motor neurons in the brain to lower motor neurons which then directly innervate muscle to produce movement. The anterior corticospinal tract is usually small, varying inversely in size with the lateral corticospinal tract, which is the main part of the corticospinal tract.

<span class="mw-page-title-main">Rexed laminae</span>

The Rexed laminae comprise a system of ten layers of grey matter (I–X), identified in the early 1950s by Bror Rexed to label portions of the grey columns of the spinal cord.

<span class="mw-page-title-main">Alpha motor neuron</span>

Alpha (α) motor neurons (also called alpha motoneurons), are large, multipolar lower motor neurons of the brainstem and spinal cord. They innervate extrafusal muscle fibers of skeletal muscle and are directly responsible for initiating their contraction. Alpha motor neurons are distinct from gamma motor neurons, which innervate intrafusal muscle fibers of muscle spindles.

<span class="mw-page-title-main">Lumbar ganglia</span>

The lumbar ganglia are paravertebral ganglia located in the inferior portion of the sympathetic trunk. The lumbar portion of the sympathetic trunk typically has 4 lumbar ganglia. The lumbar splanchnic nerves arise from the ganglia here, and contribute sympathetic efferent fibers to the nearby plexuses. The first two lumbar ganglia have both white and gray rami communicates.

The Golgi tendon reflex (also called inverse stretch reflex, autogenic inhibition, tendon reflex) is an inhibitory effect on the muscle resulting from the muscle tension stimulating Golgi tendon organs (GTO) of the muscle, and hence it is self-induced. The reflex arc is a negative feedback mechanism preventing too much tension on the muscle and tendon. When the tension is extreme, the inhibition can be so great it overcomes the excitatory effects on the muscle's alpha motoneurons causing the muscle to suddenly relax. This reflex is also called the inverse myotatic reflex, because it is the inverse of the stretch reflex.

<span class="mw-page-title-main">Spinal cord</span> Long, tubular central nervous system structure in the vertebral column

The spinal cord is a long, thin, tubular structure made up of nervous tissue that extends from the medulla oblongata in the brainstem to the lumbar region of the vertebral column (backbone) of vertebrate animals. The center of the spinal cord is hollow and contains a structure called central canal, which contains cerebrospinal fluid. The spinal cord is also covered by meninges and enclosed by the neural arches. Together, the brain and spinal cord make up the central nervous system (CNS).

A motor pool consists of all individual motor neurons that innervate a single muscle. Each individual muscle fiber is innervated by only one motor neuron, but one motor neuron may innervate several muscle fibers. This distinction is physiologically significant because the size of a given motor pool determines the activity of the muscle it innervates: for example, muscles responsible for finer movements are innervated by motor pools consisting of higher numbers of individual motor neurons. Motor pools are also distinguished by the different classes of motor neurons that they contain. The size, composition, and anatomical location of each motor pool is tightly controlled by complex developmental pathways.

<span class="mw-page-title-main">Spinal interneuron</span> Interneuron relaying signals between sensory and motor neurons in the spinal cord

A spinal interneuron, found in the spinal cord, relays signals between (afferent) sensory neurons, and (efferent) motor neurons. Different classes of spinal interneurons are involved in the process of sensory-motor integration. Most interneurons are found in the grey column, a region of grey matter in the spinal cord.

<span class="mw-page-title-main">Byrom Bramwell</span> British physician and medical author

Sir Byrom BramwellFRSEFRCPE was a British physician and medical author. He was a general physician, but became known for his work in neurology, diseases of the heart and blood, and disorders of the endocrine organs. He was president of the Royal College of Physicians of Edinburgh.

References

  1. "Professor George Romanes: Acclaimed medical scholar whose teaching". The Independent. 17 April 2014.
  2. Minute Books of the Harveian Society. Library of the Royal College of Physicians of Edinburgh.
  3. Minute Books of the Aesculapian Club. Library of the Royal College of Physicians of Edinburgh.
  4. Romanes, George J. (1951). "The motor cell columns of the lumbo-sacral spinal cord of the cat". The Journal of Comparative Neurology. 94 (2): 313–363. doi:10.1002/cne.900940209. ISSN   1096-9861. PMID   14832391. S2CID   7481510.
  5. Jessell, Thomas M.; Sürmeli, Gülşen; Kelly, John S. (2011). "Motor Neurons and the Sense of Place". Neuron. 72 (3): 419–424. doi: 10.1016/j.neuron.2011.10.021 . PMID   22078502.