Geroprotector

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A geroprotector aims to affect the root cause of aging and age-related diseases, and thus prolong the life span of animals. [1] [2] Some possible geroprotectors include melatonin, [3] carnosine, [4] metformin, [5] rapamycin, [6] nicotinamide mononucleotide (NMN) [7] , delta sleep-inducing peptide [8] and glycine. [9]

Contents

Geroprotectors could belong to multiple classes, depending on which of the hallmarks of aging they influence. [10] [11]

The distinction between geroprotectors and senotherapeutics is an evolving area of aging research. Geroprotectors broadly aim to target multiple mechanisms of aging, prolonging lifespan and healthspan by addressing the fundamental causes of aging. Senotherapeutics, on the other hand, are a subset of therapies that specifically target senescent cells, which are dysfunctional cells that accumulate with age and contribute to inflammation and age-related diseases. [12]

See also

References

  1. ↑ Alexey Moskalev, Elizaveta Chernyagina, Anna Kudryavtseva & Mikhail Shaposhnikov (2017). "Geroprotectors: A Unified Concept and Screening Approaches". Aging and Disease. 8 (3): 354–363. doi:10.14336/AD.2016.1022. PMC   5440114 . PMID   28580190.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ↑ Alexey Moskalev, Elizaveta Chernyagina, João Pedro de Magalhães & Alex Zhavoronkov (2015). "Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease". Aging . 7 (9): 616–628. doi:10.18632/aging.100799. PMC   4600621 . PMID   26342919.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ↑ Anisimov, VN; Popovich, IG; Zabezhinski, MA; Anisimov, SV; Vesnushkin, GM; Vinogradova, IA (2006). "Melatonin as antioxidant, geroprotector and anticarcinogen". Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1757 (5–6): 573–89. doi: 10.1016/j.bbabio.2006.03.012 . PMID   16678784.
  4. ↑ Boldyrev, AA; Stvolinsky, SL; Fedorova, TN; Suslina, ZA (2010). "Carnosine as a natural antioxidant and geroprotector: From molecular mechanisms to clinical trials". Rejuvenation Research. 13 (2–3): 156–8. doi:10.1089/rej.2009.0923. PMID   20017611.
  5. ↑ Bulterijs, S (2011). "Metformin As a Geroprotector". Rejuvenation Research. 14 (5): 469–82. doi:10.1089/rej.2011.1153. PMID   21882902. S2CID   40645408.
  6. ↑ Dumas, Sabrina N; Lamming, Dudley W (2020-01-01). "Next Generation Strategies for Geroprotection via mTORC1 Inhibition". The Journals of Gerontology: Series A. 75 (1): 14–23. doi:10.1093/gerona/glz056. ISSN   1079-5006. PMC   6909887 . PMID   30794726.
  7. ↑ Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice, Cell Metabolism 24, 795–806, December 13, 2016 ª 2016 Elsevier Inc.
  8. ↑ Bondarenko, TI (2011). "Mechanism of delta-sleep inducing peptide geroprotective activity". Adv Gerontol. 24 (1): 80–92. PMID   21809625.
  9. ↑ Soh J, Raventhiran S, Lee JH, Lim ZX, Goh J, Kennedy BK, Maier AB (February 2024). "The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review". GeroScience. 46 (1): 219–239. doi:10.1007/s11357-023-00970-8. PMC   10828290 . PMID   37851316.
  10. ↑ Moskalev, Alexey; Chernyagina, Elizaveta; Kudryavtseva, Anna; Shaposhnikov, Mikhail (May 2017). "Geroprotectors: A Unified Concept and Screening Approaches". Aging and Disease. 8 (3): 354–363. doi:10.14336/AD.2016.1022. ISSN   2152-5250. PMC   5440114 . PMID   28580190.
  11. ↑ Moqri, Mahdi; Herzog, Chiara; Poganik, Jesse R.; Justice, Jamie; Belsky, Daniel W.; Higgins-Chen, Albert; Moskalev, Alexey; Fuellen, Georg; Cohen, Alan A.; Bautmans, Ivan; Widschwendter, Martin; Ding, Jingzhong; Fleming, Alexander; Mannick, Joan; Han, Jing-Dong Jackie (2023-08-31). "Biomarkers of aging for the identification and evaluation of longevity interventions". Cell. 186 (18): 3758–3775. doi:10.1016/j.cell.2023.08.003. ISSN   0092-8674.
  12. ↑ Al-Naggar, Iman M. A. (24 October 2020). "Senolytics: Targeting Senescent Cells for Age-Associated Diseases". Current Molecular Biology Reports. 6: 161–172 – via Springer.
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