The Nuremberg Code is a set of ethical research principles for human experimentation created by the court in U.S. v Brandt, one of the Subsequent Nuremberg trials that were held after the Second World War.
Karl Brandt was a German physician and Schutzstaffel (SS) officer in Nazi Germany. Trained in surgery, Brandt joined the Nazi Party in 1932 and became Adolf Hitler's escort doctor in August 1934. A member of Hitler's inner circle at the Berghof, he was selected by Philipp Bouhler, the head of Hitler's Chancellery, to administer the Aktion T4 euthanasia program. Brandt was later appointed the Reich Commissioner of Sanitation and Health. Accused of involvement in human experimentation and other war crimes, Brandt was indicted in late 1946 and faced trial before a U.S. military tribunal along with 22 others in United States of America v. Karl Brandt, et al. He was convicted, sentenced to death, and hanged on 2 June 1948.
Eugen Fischer was a German professor of medicine, anthropology, and eugenics, and a member of the Nazi Party. He served as director of the Kaiser Wilhelm Institute of Anthropology, Human Heredity, and Eugenics, and also served as rector of the Frederick William University of Berlin.
The Doctors' Trial was the first of 12 trials for war crimes of high-ranking German officials and industrialists that the United States authorities held in their occupation zone in Nuremberg, Germany, after the end of World War II. These trials were held before US military courts, not before the International Military Tribunal, but took place in the same rooms at the Palace of Justice. The trials are collectively known as the "subsequent Nuremberg trials", formally the "Trials of War Criminals before the Nuremberg Military Tribunals" (NMT).
Human subject research is systematic, scientific investigation that can be either interventional or observational and involves human beings as research subjects, commonly known as test subjects. Human subject research can be either medical (clinical) research or non-medical research. Systematic investigation incorporates both the collection and analysis of data in order to answer a specific question. Medical human subject research often involves analysis of biological specimens, epidemiological and behavioral studies and medical chart review studies. On the other hand, human subject research in the social sciences often involves surveys which consist of questions to a particular group of people. Survey methodology includes questionnaires, interviews, and focus groups.
Gerhard August Heinrich Rose was a German expert on tropical medicine. He participated in Nazi experiments on human beings at Dachau and Buchenwald without the subjects' consent. He infected Jews, Romani people, and the mentally ill with malaria and typhus. Rose was sentenced to life in prison, but he was released in 1953.
George J. Annas is the William Fairfield Warren Distinguished Professor and Director of the Center for Health Law, Ethics & Human Rights at the Boston University School of Public Health, School of Medicine, and School of Law.
Stateville Correctional Center (SCC) is a maximum security state prison for men in Crest Hill, Illinois, United States, near Chicago. It is a part of the Illinois Department of Corrections.
The Stateville Penitentiary malaria study was a controlled but ethically questionable study of the effects of malaria on prisoners of Stateville Penitentiary near Joliet, Illinois in the 1940s, conducted by the Department of Medicine at the University of Chicago in conjunction with the United States Army and the State Department. The Stateville experiment was viewed as coercive because it offered shortened sentences to participants. The Green report was written in 1945 about it by Andrew Conway Ivy, used in Nuremberg Medical Trial, which affected the Nuremberg Code, and used to discuss how medical experimentation on prisoners should be carried out.
An ethics committee is a body responsible for ensuring that medical experimentation and human subject research are carried out in an ethical manner in accordance with national and international law.
Andrew Conway Ivy was an American physician. He was appointed by the American Medical Association as its representative at the 1946 Nuremberg Medical Trial for Nazi doctors, but later fell into disrepute for advocating the fraudulent drug Krebiozen.
Nazi human experimentation was a series of medical experiments on large numbers of prisoners, including children, by Nazi Germany in its concentration camps in the early to mid 1940s, during World War II and the Holocaust. Chief target populations included Romani, Sinti, ethnic Poles, Soviet POWs, disabled Germans, and Jews from across Europe.
lcClaus Karl Schilling, also recorded as Klaus Schilling, was a German tropical medicine specialist who participated in the Nazi human experiments at the Dachau concentration camp during World War II.
Numerous experiments which are performed on human test subjects in the United States are considered unethical, because they are performed without the knowledge or informed consent of the test subjects. Such tests have been performed throughout American history, but some of them are ongoing. The experiments include the exposure of humans to many chemical and biological weapons, human radiation experiments, injections of toxic and radioactive chemicals, surgical experiments, interrogation and torture experiments, tests which involve mind-altering substances, and a wide variety of other experiments. Many of these tests are performed on children, the sick, and mentally disabled individuals, often under the guise of "medical treatment". In many of the studies, a large portion of the subjects were poor, racial minorities, or prisoners.
Human subject research legislation in the United States can be traced to the early 20th century. Human subject research in the United States was mostly unregulated until the 20th century, as it was throughout the world, until the establishment of various governmental and professional regulations and codes of ethics. Notable – and in some cases, notorious – human subject experiments performed in the US include the Tuskegee syphilis experiment, human radiation experiments, the Milgram obedience experiment and Stanford prison experiments and Project MKULTRA. With growing public awareness of such experimentation, and the evolution of professional ethical standards, such research became regulated by various legislation, most notably, those that introduced and then empowered the institutional review boards.
Michael Alan Grodin is Professor of Health Law, Bioethics, and Human Rights at the Boston University School of Public Health, where he has received the distinguished Faculty Career Award for Research and Scholarship, and 20 teaching awards, including the "Norman A. Scotch Award for Excellence in Teaching." He is also Professor of Family Medicine and Psychiatry at the Boston University School of Medicine. In addition, Dr. Grodin is the Director of the Project on Medicine and the Holocaust at the Elie Wiesel Center for Judaic Studies, and a member of the faculty of the Division of Religious and Theological Studies. He has been on the faculty at Boston University for 35 years. He completed his B.S. degree at the Massachusetts Institute of Technology, his M.D. degree from the Albert Einstein College of Medicine, and his postdoctoral and fellowship training at UCLA and Harvard University.
Various organizations have created guidelines for human subject research for various kinds of research involving human subjects and for various situations.
The Euthanasia trials were legal proceedings against the main perpetrators and accomplices involved in the euthanasia killings of the Nazi era in Germany.
Unethical human experimentation is human experimentation that violates the principles of medical ethics. Such practices have included denying patients the right to informed consent, using pseudoscientific frameworks such as race science, and torturing people under the guise of research. Around World War II, Imperial Japan and Nazi Germany carried out brutal experiments on prisoners and civilians through groups like Unit 731 or individuals like Josef Mengele; the Nuremberg Code was developed after the war in response to the Nazi experiments. Countries have carried out brutal experiments on marginalized populations. Examples include American abuses during Project MKUltra and the Tuskegee syphilis experiments, and the mistreatment of indigenous populations in Canada and Australia. The Declaration of Helsinki, developed by the World Medical Association (WMA), is widely regarded as the cornerstone document on human research ethics.
