A half-sider budgerigar is an unusual congenital condition that causes a budgerigar to display one color on one side of its body and a different color on the other.
This is not a simple genetic mutation, as can be observed in other color and pattern variations in this species. It is a rare example of a tetragametic chimera, which originates when two fertilized embryos merge during a very early stage of development — between the 2-cell and the 64-cell stage. Each half has different DNA, with genetically distinct cells and the resultant bird is in effect two budgerigars fused together to form a single autonomous individual. [1]
The half-sider's coloring is usually divided bilaterally down the center, although, it can differ depending on which stage the twin embryos merged during development. Twin embryos that merged later in development will result in a budgerigar that has a splotchier distribution of the different cell populations. [1]
In the case of the half-sider budgerigar, both embryos must possess different genetic phenotypes (one yellow-based and one white-based) [2] in order for a visible half-sider to be produced. If both "halves" were the same base, it would still be a tetragametic chimera, but not a half-sider. It is also possible for the half-sider to be male on one side and female on the other (evidenced by a half blue, half brown cere) – an example of a bilateral gynandromorph. [1]
Breeding a half-sider is unlikely to produce more half-siders, even when breeding two half-siders together, as the genetic makeup of the half that contributed the cells that make up the reproductive system is that which would then be perpetuated, assuming that the bird is even fertile in the first place. The chance of producing another half-sider would be the same as for any other budgerigar pairing. [3]
An embryo is the initial stage of development for a multicellular organism. In organisms that reproduce sexually, embryonic development is the part of the life cycle that begins just after fertilization of the female egg cell by the male sperm cell. The resulting fusion of these two cells produces a single-celled zygote that undergoes many cell divisions that produce cells known as blastomeres. The blastomeres are arranged as a solid ball that when reaching a certain size, called a morula, takes in fluid to create a cavity called a blastocoel. The structure is then termed a blastula, or a blastocyst in mammals.
In botany, apomixis is asexual development of seed or embryo without fertilization. However, other definitions include replacement of the seed by a plantlet or replacement of the flower by bulbils.
Twins are two offspring produced by the same pregnancy. Twins can be either monozygotic ('identical'), meaning that they develop from one zygote, which splits and forms two embryos, or dizygotic, meaning that each twin develops from a separate egg and each egg is fertilized by its own sperm cell. Since identical twins develop from one zygote, they will share the same sex, while fraternal twins may or may not. In very rare cases twins can have the same mother and different fathers.
A genetic chimerism or chimera is a single organism composed of cells with more than one distinct genotype. In animals and human chimeras, this means an individual derived from two or more zygotes, which can include possessing blood cells of different blood types, and subtle variations in form (phenotype). Animal chimeras are produced by the merger of two embryos. In plant chimeras, however, the distinct types of tissue may originate from the same zygote, and the difference is often due to mutation during ordinary cell division. Normally, genetic chimerism is not visible on casual inspection; however, it has been detected in the course of proving parentage. More practically, in agronomy Chimera indicates a plant or portion of a plant whose tissues are made up of two or more types of cells with different genetic makeup; it can derive from a bud mutation or, more rarely, at the grafting point, from the concrescence of cells of the two bionts; in this case it is improperly known with the name of "graft hybrid".
Embryology is the branch of animal biology that studies the prenatal development of gametes, fertilization, and development of embryos and fetuses. Additionally, embryology encompasses the study of congenital disorders that occur before birth, known as teratology.
An egg is an organic vessel grown by an animal to carry a possibly fertilized egg cell and to incubate from it an embryo within the egg until the embryo has become an animal fetus that can survive on its own, at which point the animal hatches.
In biology, a blastomere is a type of cell produced by cell division (cleavage) of the zygote after fertilization; blastomeres are an essential part of blastula formation, and blastocyst formation in mammals.
The endosperm is a tissue produced inside the seeds of most of the flowering plants following double fertilization. It is triploid in most species, which may be auxin-driven. It surrounds the embryo and provides nutrition in the form of starch, though it can also contain oils and protein. This can make endosperm a source of nutrition in animal diet. For example, wheat endosperm is ground into flour for bread, while barley endosperm is the main source of sugars for beer production. Other examples of endosperm that forms the bulk of the edible portion are coconut "meat" and coconut "water", and corn. Some plants, such as certain orchids, lack endosperm in their seeds.
The somites are a set of bilaterally paired blocks of paraxial mesoderm that form in the embryonic stage of somitogenesis, along the head-to-tail axis in segmented animals. In vertebrates, somites subdivide into the dermatomes, myotomes, sclerotomes and syndetomes that give rise to the vertebrae of the vertebral column, rib cage, part of the occipital bone, skeletal muscle, cartilage, tendons, and skin.
A gynandromorph is an organism that contains both male and female characteristics. The term comes from the Greek γυνή (gynē) 'female', ἀνήρ (anēr) 'male', and μορφή (morphē) 'form', and is used mainly in the field of entomology. Gynandromorphism is most frequently recognized in organisms that have strong sexual dimorphism such as certain butterflies, spiders, and birds, but has been recognized in numerous other types of organisms.
In embryology, cleavage is the division of cells in the early development of the embryo, following fertilization. The zygotes of many species undergo rapid cell cycles with no significant overall growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula, or of the blastocyst in mammals.
Superfecundation is the fertilization of two or more ova from the same cycle by sperm from separate acts of sexual intercourse, which can lead to twin babies from two separate biological fathers. The term superfecundation is derived from fecund, meaning able to produce offspring. Homopaternal superfecundation is fertilization of two separate ova from the same father, leading to fraternal twins, while heteropaternal superfecundation is a form of atypical twinning where, genetically, the twins are half siblings – sharing the same mother, but with different fathers.
A polar body is a small haploid cell that is formed at the same time as an egg cell during oogenesis, but generally does not have the ability to be fertilized. It is named from its polar position in the egg.
A sheep–goat hybrid is a hybrid between a sheep and a goat.
Human embryonic development or human embryogenesis is the development and formation of the human embryo. It is characterised by the processes of cell division and cellular differentiation of the embryo that occurs during the early stages of development. In biological terms, the development of the human body entails growth from a one-celled zygote to an adult human being. Fertilization occurs when the sperm cell successfully enters and fuses with an egg cell (ovum). The genetic material of the sperm and egg then combine to form the single cell zygote and the germinal stage of development commences. Human embryonic development covers the first eight weeks of development, which have 23 stages, called Carnegie stages. At the beginning of the ninth week, the embryo is termed a fetus. In comparison to the embryo, the fetus has more recognizable external features and a more complete set of developing organs.
The English Grey budgerigar mutation is one of approximately 30 mutations affecting the colour of budgerigars. It appeared briefly in the 1930s but was lost shortly after and until recently was believed to be no longer extant. However, the appearance of the anthracite budgerigar mutation in 1998 with a seemingly identical appearance and identical genetic behaviour, insofar as can now be determined, suggests the mutation may have been regained.
A knockout mouse, or knock-out mouse, is a genetically modified mouse in which researchers have inactivated, or "knocked out", an existing gene by replacing it or disrupting it with an artificial piece of DNA. They are important animal models for studying the role of genes which have been sequenced but whose functions have not been determined. By causing a specific gene to be inactive in the mouse, and observing any differences from normal behaviour or physiology, researchers can infer its probable function.
46,XX/46,XY is a chimeric genetic condition characterized by the presence of some cells that express a 46,XX karyotype and some cells that express a 46,XY karyotype in a single human being. The cause of the condition lies in conception or utero with the aggregation of two distinct zygotes or blastocysts into a single embryo, which subsequently leads to the development of a single individual with two distinct cell lines, instead of a pair of fraternal twins. This is not to be confused with mosaicism or hybridism, neither of which are chimeric conditions, but is considered as an intersex condition.
A human–animal hybrid and animal–human hybrid is an organism that incorporates elements from both humans and non-human animals. Technically, in a human–animal hybrid, each cell has both human and non-human genetic material. It is in contrast to an individual where some cells are human and some are derived from a different organism, called a human-animal chimera.
A human chimera is a human with a subset of cells with a distinct genotype than other cells, that is, having genetic chimerism. In contrast, an individual where each cell contains genetic material from a human and an animal is called a human–animal hybrid, while an organism that contains a mixture of human and non-human cells would be a human-animal chimera.