Hepatitis C stem-loop IV

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Hepatitis C stem-loop IV
RF00469.jpg
Predicted secondary structure and sequence conservation of HCV_SLIV
Identifiers
SymbolHCV_SLIV
Rfam RF00469
Other data
RNA type Cis-reg
Domain(s) Viruses
SO SO:0000233
PDB structures PDBe

The Hepatitis C stem-loop IV is part of a putative RNA element found in the NS5B coding region. This element along with stem-loop VII, is important (but not essential) for colony formation, though its exact function and mechanism are unknown. [1]

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<span class="mw-page-title-main">Retroviral psi packaging element</span>

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Non-structural protein 5B (NS5B) inhibitors are a class of direct-acting antivirals widely used in the treatment of chronic hepatitis C. Depending on site of action and chemical composition, NS5B inhibitors may be categorized into three classes—nucleoside active site inhibitors (NIs), non-nucleoside allosteric inhibitors, and pyrophosphate analogues. Subsequently, all three classes are then subclassified. All inhibit RNA synthesis by NS5B but at different stages/sites resulting in inability of viral RNA replication. Expression of direct-acting NS5B inhibitors does not takes place cells that are not infected by hepatitis C virus, which seems to be beneficial for this class of drugs.

<span class="mw-page-title-main">Flavivirus 5' UTR</span> Untranslated regions in the genome of viruses in the genus Flavivirus

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References

  1. Lee H, Shin H, Wimmer E, Paul AV (October 2004). "cis-acting RNA signals in the NS5B C-terminal coding sequence of the hepatitis C virus genome". Journal of Virology. 78 (20): 10865–10877. doi:10.1128/JVI.78.20.10865-10877.2004. PMC   521798 . PMID   15452207.