Hepatitis C virus 3'X element

Last updated
Hepatitis C virus 3'X element
RF00481.jpg
Identifiers
SymbolHCV_X3
Rfam RF00481
Other data
RNA type Cis-reg
Domain(s) Viruses
SO 0000233
PDB structures PDBe

The Hepatitis C virus 3'X element is an RNA element which contains three stem-loop structures that are essential for replication. [1] [2] [3]

Cis-regulatory elements (CREs) are regions of non-coding DNA which regulate the transcription of neighboring genes. CREs are vital components of genetic regulatory networks, which in turn control morphogenesis, the development of anatomy, and other aspects of embryonic development, studied in evolutionary developmental biology.

Stem-loop intramolecular base-pairing pattern in RNA and also DNA

Stem-loop intramolecular base pairing is a pattern that can occur in single-stranded DNA or, more commonly, in RNA. The structure is also known as a hairpin or hairpin loop. It occurs when two regions of the same strand, usually complementary in nucleotide sequence when read in opposite directions, base-pair to form a double helix that ends in an unpaired loop. The resulting structure is a key building block of many RNA secondary structures. As an important secondary structure of RNA, it can direct RNA folding, protect structural stability for messenger RNA (mRNA), provide recognition sites for RNA binding proteins, and serve as a substrate for enzymatic reactions.

Contents

See also

Hepatitis C alternative reading frame stem-loop

Hepatitis C alternative reading frame stem-loop is a conserved secondary structure motif identified in the RNA genome of the Hepatitis C virus (HCV) which is proposed to have an important role in regulating translation and repression of the viral genome.

Hepatitis C stem-loop IV

The Hepatitis C stem-loop IV is part of a putative RNA element found in the NS5B coding region. This element along with stem-loop VII, is important for colony formation, though its exact function and mechanism are unknown.

Hepatitis C virus stem-loop VII

Hepatitis C virus stem-loop VII is a regulatory element found in the coding region of the RNA-dependent RNA polymerase gene, NS5B. Similarly to stem-loop IV, the stem-loop structure is important for colony formation, though its exact function and mechanism are unknown.

Related Research Articles

Hepatitis D is a disease caused by the hepatitis D virus (HDV), a small spherical enveloped virusoid. This is one of five known hepatitis viruses: A, B, C, D, and E. HDV is considered to be a subviral satellite because it can propagate only in the presence of the hepatitis B virus (HBV). Transmission of HDV can occur either via simultaneous infection with HBV (coinfection) or superimposed on chronic hepatitis B or hepatitis B carrier state (superinfection).

<i>Hepadnaviridae</i>

Hepadnaviridae is a family of viruses. Humans, apes, and birds serve as natural hosts. There are currently seven species in this family, divided among 2 genera. Its best-known member is the hepatitis B virus. Diseases associated with this family include: liver infections, such as hepatitis, hepatocellular carcinomas, and cirrhosis.

<i>Hepacivirus C</i> species of virus

Hepatitis C virus (HCV), a member of the Hepacivirus C species, is a small, enveloped, positive-sense single-stranded RNA virus of the family Flaviviridae. The hepatitis C virus is the cause of hepatitis C and some cancers such as liver cancer and lymphomas in humans.

<i>Rubella virus</i> species of virus

Rubella virus (RuV) is the pathogenic agent of the disease rubella, and is the cause of congenital rubella syndrome when infection occurs during the first weeks of pregnancy.

Coronavirus packaging signal

The Coronavirus packaging signal is a conserved cis-regulatory element found in Coronavirus which has an important role in regulating the packaging of the viral genome into the capsid.

Coronavirus SL-III cis-acting replication element

The coronavirus SL-III cis-acting replication element (CRE) is an RNA element that regulates defective interfering (DI) RNA replication.

Hepatitis C virus cis-acting replication element

The Hepatitis C virus (HCV) cis-acting replication element (CRE) is an RNA element which is found in the coding region of the RNA-dependent RNA polymerase NS5B. Mutations in this family have been found to cause a blockage in RNA replication and it is thought that both the primary sequence and the structure of this element are crucial for HCV RNA replication.

Hepatitis E virus cis-reactive element

The hepatitis E virus cis-reactive element is a RNA element that is thought to be essential for "some step in gene expression". The mutation of this element resulted in hepatitis E strains which were unable to infect rhesus macaques.

Retroviral Psi packaging element

Retroviral Psi packaging element is a cis-acting RNA element identified in the genomes of the retroviruses Human immunodeficiency virus (HIV) and Simian immunodeficiency virus (SIV). It is involved in regulating the essential process of packaging the retroviral RNA genome into the viral capsid during replication. The final virion contains a dimer of two identical unspliced copies of the viral genome.

Human parechovirus 1 (HPeV1) cis regulatory element (CRE)

The Human Parechovirus 1 cis regulatory element is an RNA element which is located in the 5'-terminal 112 nucleotides of the genome of human parechovirus 1 (HPeV1). The element consists of two stem-loop structures together with a pseudoknot. Disruption of any of these elements impairs both viral replication and growth.

Tombusvirus 5 UTR

Tombusvirus 5' UTR is an important cis-regulatory region of the Tombus virus genome.

Turnip crinkle virus (TCV) repressor of minus strand synthesis H5

The TCV hairpin 5 (H5) is an RNA element found in the turnip crinkle virus. This RNA element is composed of a stem-loop that contains a large symmetrical internal loop (LSL). H5 can repress minus-strand synthesis when the 3' side of the LSL pairs with the 4 bases at the 3'-terminus of the RNA(GCCC-OH).

NSP1, the product of rotavirus gene 5, is a nonstructural RNA-binding protein that contains a cysteine-rich region and is a component of early replication intermediates. RNA-folding predictions suggest that this region of the NSP1 mRNA can interact with itself, producing a stem-loop structure similar to that found near the 5'-terminus of the NSP1 mRNA.

Avian HBV RNA encapsidation signal epsilon

The Avian HBV RNA encapsidation signal epsilon is an RNA structure that is shown to facilitate encapsidation of the pregenomic RNA required for replication. There are two main classes of encapsidation signals in avian HBV viruses - Duck hepatitis B virus (DHBV) and Heron hepatitis B virus (HHBV) like. DHBV is used as a model to understand human HBV. Although studies have shown that the HHBV epsilon has less pairing in the upper stem than DHBV, this pairing is not absolutely required for DHBV infection in ducks.

<i>Hepatitis B virus</i> species of the genus Orthohepadnavirus

Hepatitis B virus, abbreviated HBV, is a partially double-stranded DNA virus, a species of the genus Orthohepadnavirus and a member of the Hepadnaviridae family of viruses. This virus causes the disease hepatitis B.

In molecular biology, the Hepatitis A virus cis-acting replication element (CRE) is an RNA element which is found in the coding region of the RNA-dependent RNA polymerase in Hepatitis A virus (HAV). It is larger than the CREs found in related Picornavirus species, but is thought to be functionally similar. It is thought to be involved in uridylylation of VPg.

In molecular biology, the Avian encephalitis virus cis-acting replication element (CRE) is an s an RNA element which is found in the coding region of the RNA-dependent RNA polymerase in Avian encephalitis virus (AEV). It is structurally similar to the Hepatitis A virus cis-acting replication element.

References

  1. Lee H, Shin H, Wimmer E, Paul AV (October 2004). "cis-acting RNA signals in the NS5B C-terminal coding sequence of the hepatitis C virus genome". Journal of Virology. 78 (20): 10865–77. doi:10.1128/JVI.78.20.10865-10877.2004. PMC   521798 . PMID   15452207.
  2. Yi M, Lemon SM (March 2003). "3' nontranslated RNA signals required for replication of hepatitis C virus RNA". Journal of Virology. 77 (6): 3557–68. doi:10.1128/JVI.77.6.3557-3568.2003. PMC   149512 . PMID   12610131.
  3. Yi M, Lemon SM (March 2003). "Structure-function analysis of the 3' stem-loop of hepatitis C virus genomic RNA and its role in viral RNA replication". RNA. 9 (3): 331–45. doi:10.1261/rna.2144203. PMC   1370400 . PMID   12592007.