Historically, puerperal fever was a devastating disease. It affected women within the first three days after childbirth and progressed rapidly, causing acute symptoms of severe abdominal pain, fever and debility.
The most common infection causing puerperal fever is genital tract sepsis caused by contaminated medical equipment or unhygienic medical staff who contaminate the mother's genital tract during the delivery. Other types of infection that can lead to sepsis after childbirth include urinary tract infection, breast infection (mastitis) and respiratory tract infection (more common after anaesthesia due to lesions in the trachea). Puerperal fever is now rare in the West due to improved hygiene during delivery, and the few infections that do occur are usually treatable with antibiotics.
Dr. Ignaz Semmelweis worked at the Vienna General Hospital's maternity clinic on a 3-year contract from 1846–1849. There, as elsewhere in European and North American hospitals, puerperal fever, or childbed fever, was rampant, sometimes climbing to 40 percent of admitted patients. He was disturbed by these mortality rates, and eventually developed a theory of infection, in which he theorized that decaying matter on the hands of doctors, who had recently conducted autopsies, was brought into contact with the genitals of birthgiving women during the medical examinations at the maternity clinic. He proposed a radical hand washing theory using chlorinated lime, now a known disinfectant.[ citation needed ]
At the time however, the germ theory of infection had not been developed and Semmelweis' ideas ran contrary to key medical beliefs and practices. His ideas were rejected and ridiculed. Quite unusually, his contract was not renewed, effectively expelling him from the medical community in Vienna. He died as an outcast in a mental institution.
An 1841 account of epidemic childbed fever states that insofar as existing historical documents permit one to judge, childbed fever is a modern disease. The cases reported by Hippocrates that are generally identified as such are not puerperal fever. There are only examples of bilious fever, then common, which among maternity patients was no different from its appearance among non-maternity patients or men; Hippocrates himself never identified it as a separate and distinguishable disease. [1]
We encounter the first, as yet unclear indication of childbed fever in the second half of the 17th century at the Hôtel-Dieu in Paris. Phillipe Peu relates that mortality among the newly delivered was very great and greater in certain seasons than others. The year 1664 was particularly devastating. [1]
Another account states that the lower abdominal infection, la fièvre puerpérale, had raged every winter since 1774 among the maternity patients of the Hôtel-Dieu, and that often as many as 7 of every 12 patients suffered from it. [2]
For the relatively small maternity clinic at Würzburg in Germany, Franz Kiwisch von Rotterau reported 27 deaths from 102 patients (26.5%) cared for during one year, much higher than the Viennese hospital. Semmelweis explained this from the need in small hospitals to use every patient as teaching material. In contrast, "in Vienna there is such an excess of teaching material that hundreds of individuals are not used for teaching and thus are not infected". [3]
There are various inconsistencies in the datasets reported by Semmelweis and provided below.[ citation needed ] Inconsistencies exist for instance in reported yearly rates, and monthly rates (if aggregated to yearly basis). One of the causes may be that Semmelweis used different sources. He points out several times that actual mortality rates were higher than reported ones, because during childbed fever epidemics, the maternity ward was overwhelmed with dying women, who were then transferred to the general hospital, and therefore not registered at the maternity ward, when dying. [4] Some women were also released from the maternity ward, either healthy or not so healthy, only to be readmitted to the general hospital when symptoms appeared or worsened. See also a similar underreporting practice at the Charité in Berlin, Joseph Hermann Schmidt.
There were two maternity clinics at the Vienna General Hospital. Semmelweis is not always specific, if the numbers are for both clinics, or for his own clinic only. The figures presented below are exactly as reported in (the 1983 translation by Carter of) Semmelweis' 1861 publication.
There are also at times minor arithmetical errors in his computed rates; for this reason all rates on this page are computed.
The table below shows monthly incidence rates from 1841–1849, Semmelweis' handwashing policy was implemented from June 1847 to February 1849.
Year | Month | Births | Deaths | Rate (%) | Notes |
---|---|---|---|---|---|
1841 | January 1841 | 254 | 37 | 14.6 | |
February 1841 | 239 | 18 | 7.5 | ||
March 1841 | 277 | 12 | 4.3 | ||
April 1841 | 255 | 4 | 1.6 | ||
May 1841 | 255 | 2 | 0.8 | ||
June 1841 | 200 | 10 | 5.0 | ||
July 1841 | 190 | 16 | 8.4 | ||
August 1841 | 222 | 3 | 1.4 | ||
September 1841 | 213 | 4 | 1.9 | ||
October 1841 | 236 | 26 | 11.0 | ||
November 1841 | 235 | 53 | 22.6 | ||
December 1841 | na | na | na | ||
1842 | January 1842 | 307 | 64 | 20.8 | |
February 1842 | 311 | 38 | 12.2 | ||
March 1842 | 264 | 27 | 10.2 | ||
April 1842 | 242 | 26 | 10.7 | ||
May 1842 | 310 | 10 | 3.2 | ||
June 1842 | 273 | 18 | 6.6 | ||
July 1842 | 231 | 48 | 20.8 | ||
August 1842 | 216 | 55 | 25.5 | ||
September 1842 | 223 | 41 | 18.4 | ||
October 1842 | 242 | 71 | 29.3 | ||
November 1842 | 209 | 48 | 23.0 | ||
December 1842 | 239 | 75 | 31.4 | ||
1843 | January 1843 | 272 | 52 | 19.1 | |
February 1843 | 263 | 42 | 16.0 | ||
Mar 1843 | 266 | 33 | 12.4 | ||
April 1843 | 285 | 34 | 11.9 | ||
May 1843 | 246 | 15 | 6.1 | ||
June 1843 | 196 | 8 | 4.1 | ||
July 1843 | 191 | 1 | 0.5 | ||
August 1843 | 193 | 3 | 1.6 | ||
September 1843 | 221 | 5 | 2.3 | ||
October 1843 | 250 | 44 | 17.6 | ||
November 1843 | 252 | 18 | 7.1 | ||
December 1843 | 236 | 19 | 8.1 | ||
1844 | January 1844 | 244 | 37 | 15.2 | |
February 1844 | 257 | 29 | 11.3 | ||
March 1844 | 276 | 47 | 17.0 | ||
April 1844 | 208 | 36 | 17.3 | ||
May 1844 | 240 | 14 | 5.8 | ||
June 1844 | 224 | 6 | 2.7 | ||
July 1844 | 206 | 9 | 4.4 | ||
August 1844 | 269 | 17 | 6.3 | ||
September 1844 | 245 | 3 | 1.2 | ||
October 1844 | 248 | 8 | 3.2 | ||
November 1844 | 245 | 27 | 11.0 | ||
December 1844 | 256 | 27 | 10.5 | ||
1845 | January 1845 | 303 | 23 | 7.6 | |
February 1845 | 274 | 13 | 4.7 | ||
March 1845 | 292 | 13 | 4.5 | ||
April 1845 | 260 | 11 | 4.2 | ||
May 1845 | 296 | 13 | 4.4 | ||
June 1845 | 280 | 20 | 7.1 | ||
July 1845 | 245 | 15 | 6.1 | ||
August 1845 | 251 | 9 | 3.6 | ||
September 1845 | 237 | 25 | 10.5 | ||
October 1845 | 283 | 42 | 14.8 | ||
November 1845 | 265 | 29 | 10.9 | ||
December 1845 | 267 | 28 | 10.5 | ||
1846 | January 1846 | 336 | 45 | 13.4 | |
February 1846 | 293 | 53 | 18.1 | ||
March 1846 | 311 | 48 | 15.4 | ||
April 1846 | 253 | 48 | 19.0 | ||
May 1846 | 305 | 41 | 13.4 | ||
June 1846 | 266 | 27 | 10.2 | ||
July 1846 | 252 | 33 | 13.1 | ||
August 1846 | 216 | 39 | 18.1 | ||
September 1846 | 271 | 39 | 14.4 | ||
October 1846 | 254 | 38 | 15.0 | ||
November 1846 | 297 | 32 | 10.8 | ||
December 1846 | 298 | 16 | 5.4 | ||
1847 | January 1847 | 311 | 10 | 3.2 | |
February 1847 | 312 | 6 | 1.9 | ||
March 1847 | 305 | 11 | 3.6 | ||
April 1847 | 312 | 57 | 18.3 | ||
May 1847 | 294 | 36 | 12.2 | Handwashing policy instituted mid-May | |
June 1847 | 268 | 6 | 2.2 | ||
July 1847 | 250 | 3 | 1.2 | ||
August 1847 | 264 | 5 | 1.9 | ||
September 1847 | 262 | 12 | 4.6 | ||
October 1847 | 278 | 11 | 4.0 | ||
November 1847 | 246 | 11 | 4.5 | ||
December 1847 | 273 | 8 | 2.9 | ||
1848 | January 1848 | 283 | 10 | 3.5 | strict controls enforced on students' negligent hand-wash |
February 1848 | 291 | 2 | 0.7 | ||
March 1848 | 276 | 0 | 0.0 | ||
April 1848 | 305 | 2 | 0.7 | ||
May 1848 | 313 | 3 | 1.0 | ||
June 1848 | 264 | 3 | 1.1 | ||
July 1848 | 269 | 1 | 0.4 | ||
August 1848 | 261 | 0 | 0.0 | ||
September 1848 | 312 | 3 | 1.0 | ||
October 1848 | 299 | 7 | 2.3 | ||
November 1848 | 310 | 9 | 2.9 | ||
December 1848 | 373 | 5 | 1.3 | ||
1849 | January 1849 | 403 | 9 | 2.2 | |
February 1849 | 389 | 12 | 3.1 | ||
March 1849 | 406 | 20 | 4.9 | Semmelweis' employment terminated |
From his theory of decaying matter on the hands of examining physicians as a cause for childbed fever he was able to explain other features in the dataset, for instance why mortality rates were remarkably higher during winter than summer, because of increased student activity and scheduled autopsies immediately before the rounds at the maternity clinic. He writes:
He was able to explain additional features:
A second clinic was started in 1833 because of the large number of women being admitted to the maternity ward. Medical students and midwife students undertook their studies at both clinics. In 1841 however, these two groups were separated. Thereafter, medical students attended the first clinic only, and midwife students attended the second clinic only. Joseph Späth was professor at the second clinic.
First clinic | Second clinic | |||||||
---|---|---|---|---|---|---|---|---|
Year | Births | Deaths | Rate (%) | Births | Deaths | Rate (%) | Note | |
1833 | 3,737 | 197 | 5.3 | 353 | 8 | 2.3 | Second clinic started | |
1834 | 2,657 | 205 | 7.7 | 1,744 | 150 | 8.6 | ||
1835 | 2,573 | 143 | 5.6 | 1,682 | 84 | 5.0 | ||
1836 | 2,677 | 200 | 7.5 | 1,670 | 131 | 7.8 | ||
1837 | 2,765 | 251 | 9.1 | 1,784 | 124 | 7.0 | ||
1838 | 2,987 | 91 | 3.0 | 1,779 | 88 | 4.9 | ||
1839 | 2,781 | 151 | 5.4 | 2,010 | 91 | 4.5 | ||
1840 | 2,889 | 267 | 9.2 | 2,073 | 55 | 2.7 | ||
1841 | 3,036 | 237 | 7.8 | 2,442 | 86 | 3.5 | Only midwives worked in the second clinic | |
1842 | 3,287 | 518 | 15.8 | 2,659 | 202 | 7.6 | ||
1843 | 3,060 | 274 | 9.0 | 2,739 | 164 | 6.0 | ||
1844 | 3,157 | 260 | 8.2 | 2,956 | 68 | 2.3 | ||
1845 | 3,492 | 241 | 6.9 | 3,241 | 66 | 2.0 | ||
1846 | 4,010 | 459 | 11.4 | 3,754 | 105 | 2.8 | ||
1847 | 3,490 | 176 | 5.0 | 3,306 | 32 | 1.0 | Handwashing in first clinic mid-May | |
1848 | 3,556 | 45 | 1.3 | 3,319 | 43 | 1.3 | ||
1849 | 3,858 | 103 | 2.7 | 3,371 | 87 | 2.6 | Semmelweis dismissed in March | |
1850 | 3,745 | 74 | 2.0 | 3,261 | 54 | 1.7 | ||
1851 | 4,194 | 75 | 1.8 | 3,395 | 121 | 3.6 | ||
1852 | 4,471 | 181 | 4.0 | 3,360 | 192 | 5.7 | ||
1853 | 4,221 | 94 | 2.2 | 3,480 | 67 | 1.9 | ||
1854 | 4,393 | 400 | 9.1 | 3,396 | 210 | 6.2 | ||
1855 | 3,659 | 198 | 5.4 | 2,938 | 174 | 5.9 | ||
1856 | 3,925 | 156 | 4.0 | 3,070 | 125 | 4.1 | ||
1857 | 4,220 | 124 | 2.9 | 3,795 | 83 | 2.2 | ||
1858 | 4,203 | 86 | 2.0 | 4,179 | 60 | 1.4 |
Semmelweis seeks to demonstrate that the advent of pathological anatomy, and consequently the increase in autopsies, is correlated to the incidence of childbed fever. From 1789–1822 professor Johann Lucas Boër was assigned the teaching post at the maternity ward, however he left the post discouraged of what was then regarded as an enormous mortality rate. He was succeeded by professor Johann Klein who reformed obstetrics to an anatomical orientation emphasizing the value of pathological autopsies. Mortality rates jump markedly.
Year | Births | Deaths | Rate (%) | Note |
1784 | 284 | 6 | 2.1 | No pathological anatomy |
1785 | 899 | 13 | 1.4 | |
1786 | 1,151 | 5 | 0.4 | |
1787 | 1,407 | 5 | 0.4 | |
1788 | 1,425 | 5 | 0.4 | |
1789 | 1,246 | 7 | 0.6 | |
1790 | 1,326 | 10 | 0.8 | |
1791 | 1,395 | 8 | 0.6 | |
1792 | 1,579 | 14 | 0.9 | |
1793 | 1,684 | 44 | 2.6 | |
1794 | 1,768 | 7 | 0.4 | |
1795 | 1,798 | 38 | 2.1 | |
1796 | 1,904 | 22 | 1.2 | |
1797 | 2,012 | 5 | 0.2 | |
1798 | 2,046 | 5 | 0.2 | |
1799 | 2,067 | 20 | 1.0 | |
1800 | 2,070 | 41 | 2.0 | |
1801 | 2,106 | 17 | 0.8 | |
1802 | 2,346 | 9 | 0.4 | |
1803 | 2,215 | 16 | 0.7 | |
1804 | 2,022 | 8 | 0.4 | |
1805 | 2,112 | 9 | 0.4 | |
1806 | 1,875 | 13 | 0.7 | |
1807 | 925 | 6 | 0.6 | |
1808 | 855 | 7 | 0.8 | |
1809 | 912 | 13 | 1.4 | |
1810 | 744 | 6 | 0.8 | |
1811 | 1,050 | 20 | 1.9 | |
1812 | 1,419 | 9 | 0.6 | |
1813 | 1,945 | 21 | 1.1 | |
1814 | 2,062 | 66 | 3.2 | |
1815 | 2,591 | 19 | 0.7 | |
1816 | 2,410 | 12 | 0.5 | |
1817 | 2,735 | 25 | 0.9 | |
1818 | 2,568 | 56 | 2.2 | |
1819 | 3,089 | 154 | 5.0 | |
1820 | 2,998 | 75 | 2.5 | |
1821 | 3,294 | 55 | 1.7 | |
1822 | 3,066 | 26 | 0.8 | |
1823 | 2,872 | 214 | 7.5 | Pathological anatomy begins |
1824 | 2,911 | 144 | 4.9 | |
1825 | 2,594 | 229 | 8.8 | |
1826 | 2,359 | 192 | 8.1 | |
1827 | 2,367 | 51 | 2.2 | |
1828 | 2,833 | 101 | 3.6 | |
1829 | 3,012 | 140 | 4.6 | |
1830 | 2,797 | 111 | 4.0 | |
1831 | 3,353 | 222 | 6.6 | |
1832 | 3,331 | 105 | 3.2 | |
1833 | 3,737 | 197 | 5.3 | |
1834 | 2,657 | 205 | 7.7 | |
1835 | 2,573 | 143 | 5.6 | |
1836 | 2,677 | 200 | 7.5 | |
1837 | 2,765 | 251 | 9.1 | |
1838 | 2,987 | 91 | 3.0 | |
1839 | 2,781 | 151 | 5.4 | |
1840 | 2,889 | 267 | 9.2 | |
1841 | 3,036 | 237 | 7.8 | Separation of clinics |
1842 | 3,287 | 518 | 15.8 | hereafter numbers refer to first clinic only |
1843 | 3,060 | 274 | 9.0 | |
1844 | 3,157 | 260 | 8.2 | |
1845 | 3,492 | 241 | 6.9 | |
1846 | 4,010 | 459 | 11.4 | |
1847 | 3,490 | 176 | 5.0 | Chlorine washings begin mid-May |
1848 | 3,556 | 45 | 1.3 | |
1849 | 3,858 | 103 | 2.7 | Semmelweis dismissed from hospital in March |
The mortality rate for newborn infants was also higher in the first clinic.
First clinic | Second clinic | ||||||
Year | Births | Deaths | Rate (%) | Births | Deaths | Rate (%) | |
1841 | 2,813 | 177 | 6.3 | 2,252 | 91 | 4.0 | |
1842 | 3,037 | 279 | 9.2 | 2,414 | 113 | 4.7 | |
1843 | 2,828 | 195 | 6.9 | 2,570 | 130 | 5.1 | |
1844 | 2,917 | 251 | 8.6 | 2,739 | 100 | 3.7 | |
1845 | 3,201 | 260 | 8.1 | 3,017 | 97 | 3.2 | |
1846 | 3,533 | 235 | 6.7 | 3,398 | 86 | 2.5 |
Semmelweis compared mortality rates in Vienna with maternity institutions in the United Kingdom where mortality rates were lower. He wished to show that childbed fever was related to pathological anatomy. His choice, Dublin Maternity Hospital, was like the Viennese hospital, a large teaching institution for physicians.
He argued that, as a rule, German and French maternity hospitals are associated with large general hospitals. Therefore, their students occupy themselves in morgues, and in medical and surgical wards, as well as in maternity wards. In this way they become carriers of the decaying matter responsible for childbed fever.
Contrary hereto, maternity hospitals in the United Kingdom were independent institutions; removed from general hospitals. The students are forced to concern themselves exclusively with obstetrics, they do not carry out pathological autopsies. [13]
Year | Births | Deaths | Rate (%) |
---|---|---|---|
1784 | 1261 | 11 | 0.9 |
1785 | 1292 | 8 | 0.6 |
1786 | 1351 | 8 | 0.6 |
1787 | 1347 | 10 | 0.7 |
1788 | 1469 | 23 | 1.6 |
1789 | 1435 | 25 | 1.7 |
1790 | 1546 | 12 | 0.8 |
1791 | 1602 | 25 | 1.6 |
1792 | 1631 | 10 | 0.6 |
1793 | 1747 | 19 | 1.1 |
1794 | 1543 | 20 | 1.3 |
1795 | 1503 | 7 | 0.5 |
1796 | 1621 | 10 | 0.6 |
1797 | 1712 | 13 | 0.8 |
1798 | 1604 | 8 | 0.5 |
1799 | 1537 | 10 | 0.7 |
1800 | 1837 | 18 | 1 |
1801 | 1725 | 30 | 1.7 |
1802 | 1985 | 26 | 1.3 |
1803 | 2028 | 44 | 2.2 |
1804 | 1915 | 16 | 0.8 |
1805 | 2220 | 12 | 0.5 |
1806 | 2406 | 23 | 1 |
1807 | 2511 | 12 | 0.5 |
1808 | 2665 | 13 | 0.5 |
1809 | 2889 | 21 | 0.7 |
1810 | 2854 | 29 | 1 |
1811 | 2561 | 24 | 0.9 |
1812 | 2676 | 43 | 1.6 |
1813 | 2484 | 62 | 2.5 |
1814 | 2508 | 25 | 1 |
1815 | 3075 | 17 | 0.6 |
1816 | 3314 | 18 | 0.5 |
1817 | 3473 | 32 | 0.9 |
1818 | 3539 | 56 | 1.6 |
1819 | 3197 | 94 | 2.9 |
1820 | 2458 | 70 | 2.8 |
1821 | 2849 | 22 | 0.8 |
1822 | 2675 | 12 | 0.4 |
1823 | 2584 | 59 | 2.3 |
1824 | 2446 | 20 | 0.8 |
1825 | 2740 | 26 | 0.9 |
1826 | 2440 | 81 | 3.3 |
1827 | 2550 | 33 | 1.3 |
1828 | 2856 | 43 | 1.5 |
1829 | 2141 | 34 | 1.6 |
1830 | 2288 | 12 | 0.5 |
1831 | 2176 | 12 | 0.6 |
1832 | 2242 | 12 | 0.5 |
1833 | 2138 | 12 | 0.6 |
1834 | 2024 | 34 | 1.7 |
1835 | 1902 | 34 | 1.8 |
1836 | 1810 | 36 | 2 |
1837 | 1833 | 24 | 1.3 |
1838 | 2126 | 45 | 2.1 |
1839 | 1951 | 25 | 1.3 |
1840 | 1521 | 26 | 1.7 |
1841 | 2003 | 23 | 1.1 |
1842 | 2171 | 21 | 1 |
1843 | 2210 | 22 | 1 |
1844 | 2288 | 14 | 0.6 |
1845 | 1411 | 35 | 2.5 |
1846 | 2025 | 17 | 0.8 |
1847 | 1703 | 47 | 2.8 |
1848 | 1816 | 35 | 1.9 |
1849 | 2063 | 38 | 1.8 |
The second obstetrical clinic at Vienna General Hospital that instructed midwife students evidently had a lower mortality rate than the first obstetrical clinic, where physicians were instructed.
While the midwife students in Vienna were not partaking in autopsies, there were still opportunities for them to contaminate their hands. In a lecture in 1846 Jakob Kolletschka is reputed to have said, "It is here no uncommon thing for midwives, especially in the commencement of their practice, to pull off legs and arms of infants, and even to pull away the entire body and leave the head in the uterus. Such occurrences are not altogether uncommon; they often happen." [15]
The Maternité in Paris was an exception. It was exclusively for the education of midwives, but it had a mortality rate as great as Paul-Antoine Dubois's Paris Clinic for the education of physicians. In the Maternité, midwives participated in autopsies as frequently physicians would elsewhere.
The hospital midwives and some of their students accompanied the physician on his daily rounds through the infirmary for maternity patients. Each student was assigned a diseased patient for particular observation and was expected to prepare a short case history of the birth and of the physician's treatment. Autopsies were conducted in a building in the garden somewhat removed from the maternity hospital; these were usually attended by student midwives. I was often astonished to see the active part some of the young women took in the dissection of corpses. With bare and bloody arms, holding large knives in their hands, laughing and quarreling, they cut the pelvis apart, having received permission from the physician to prepare the corpse for him. [16]
Obstetrics is the field of study concentrated on pregnancy, childbirth and the postpartum period. As a medical specialty, obstetrics is combined with gynecology under the discipline known as obstetrics and gynecology (OB/GYN), which is a surgical field.
Ignaz Philipp Semmelweis was a Hungarian physician and scientist of German descent, who was an early pioneer of antiseptic procedures, and was described as the "saviour of mothers". Postpartum infection, also known as puerperal fever or childbed fever, consists of any bacterial infection of the reproductive tract following birth, and in the 19th century was common and often fatal. Semmelweis discovered that the incidence of infection could be drastically reduced by requiring healthcare workers in obstetrical clinics to disinfect their hands. In 1847, he proposed hand washing with chlorinated lime solutions at Vienna General Hospital's First Obstetrical Clinic, where doctors' wards had three times the mortality of midwives' wards. The maternal mortality rate dropped from 18% to less than 2%, and he published a book of his findings, Etiology, Concept and Prophylaxis of Childbed Fever in 1861.
Postpartum infections, also known as childbed fever and puerperal fever, are any bacterial infections of the female reproductive tract following childbirth or miscarriage. Signs and symptoms usually include a fever greater than 38.0 °C (100.4 °F), chills, lower abdominal pain, and possibly bad-smelling vaginal discharge. It usually occurs after the first 24 hours and within the first ten days following delivery.
Johann Baptist Chiari was an Austrian gynecologist and obstetrician born in Salzburg.
The Cry and the Covenant is a novel by Morton Thompson written in 1949 and published by Doubleday. The novel is a fictionalized story of Ignaz Semmelweis, an Austrian-Hungarian physician known for his research into puerperal fever and his advances in medical hygiene. The novel includes historical references, and details into Semmelweis' youth and education, as well as his later studies.
Jakob Kolletschka was Professor of Forensic Medicine at Vienna General Hospital in Austria.
Carl Edvard Marius Levy was professor and head of the Danish Maternity institution in Copenhagen. His name is sometimes spelled "Carl Eduard Marius Levy" or, in foreign literature, "Karl Edouard Marius Levy".
Johann Klein was professor of obstetrics at the University of Salzburg and at the University of Vienna. Johann Baptist Chiari was his son-in-law. In Vienna, he was succeeded by professor Carl Braun in 1856.
Carl Braun, sometimes Carl Rudolf Braun alternative spelling: Karl Braun, or Karl von Braun-Fernwald, name after knighthood Carl Ritter von Fernwald Braun was an Austrian obstetrician. He was born 22 March 1822 in Zistersdorf, Austria, son of the medical doctor Carl August Braun.
Johann Lucas Boër, originally Johann Lucas Boogers was a German medical doctor and obstetrician.
Joseph Späth was professor of obstetrics in Vienna, and from 1873 to 1886 he was director of the second obstetrical clinic at the Vienna General Hospital.
Ignaz Semmelweis discovered in 1847 that hand-washing with a solution of chlorinated lime reduced the incidence of fatal childbed fever tenfold in maternity institutions. However, the reaction of his contemporaries was not positive; his subsequent mental disintegration led to him being confined to an insane asylum, where he died in 1865.
The Semmelweis reflex or "Semmelweis effect" is a metaphor for the reflex-like tendency to reject new evidence or new knowledge because it contradicts established norms, beliefs, or paradigms.
Joseph Hermann Schmidt was professor of obstetrics in Berlin, and official of the Prussian cultural ministry.
Carl Mayrhofer was a physician conducting work on the role of germs in childbed fever.
Etiology, Concept and Prophylaxis of Childbed Fever is a pioneering medical book by Ignaz Semmelweis published in 1861, which explains how hygiene in hospitals can drastically reduce unnecessary deaths. The book and concept saved millions of mothers from a preventable, streptococcal infection.
Joseph Bolivar DeLee was an American physician who became known as the father of modern obstetrics. DeLee founded the Chicago Lying-in Hospital, where he introduced the first portable infant incubator. Early in his career, he was associated with the medical school at Northwestern University. After 1929, he was employed by the medical school at the University of Chicago.
Alexander Gordon MA, MD was a Scottish obstetrician best known for clearly demonstrating the contagious nature of puerperal sepsis. By systematically recording details of all visits to women with the condition, he concluded that it was spread from patient to patient by the attending midwife or doctor, and he published these findings in his 1795 paper "Treatise on the Epidemic Puerperal Fever of Aberdeen". On the basis of these conclusions, he advised that the spread could be limited by fumigation of the clothing and burning of the bed linen used by women with the condition and by cleanliness of her medical and midwife attendants. He also recognised a connection between puerperal fever and erysipelas, a skin infection later shown to be caused by the bacterium Streptococcus pyogenes, the same organism that causes puerperal fever. His paper gave insights into the contagious nature of puerperal sepsis around half a century before the better-known publications of Ignaz Semmelweis and Oliver Wendell Holmes and some eighty years before the role of bacteria as infecting agents was clearly understood. Gordon's textbook The Practice of Physik gives valuable insights into medical practice in the later years of the Enlightenment. He advised that clinical decisions be based on personal observations and experience rather than ancient aphorisms.
Robert Collins was an Irish physician who became master of the Rotunda Hospital aged 26. He pioneered methods to control the spread of puerperal fever in the hospital, and the use of the stethoscope in obstetrics.
In the mid to late nineteenth century, scientific patterns emerged which contradicted the widely held miasma theory of disease. These findings led medical science to what we now know as the germ theory of disease. The germ theory of disease proposes that invisible microorganisms are the cause of particular illnesses in both humans and animals. Prior to medicine becoming hard science, there were many philosophical theories about how disease originated and was transmitted. Though there were a few early thinkers that described the possibility of microorganisms, it was not until the mid to late nineteenth century when several noteworthy figures made discoveries which would provide more efficient practices and tools to prevent and treat illness. The mid-19th century figures set the foundation for change, while the late-19th century figures solidified the theory.