IGHV@

IGHV@
Identifiers
Aliases
External IDs	GeneCards: ; OMA:- orthologs
Orthologs Species Human Mouse Entrez n/a n/a Ensembl n/a n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a n/a
Wikidata
View/Edit Human

Ig heavy chain V-III region VH26 is a protein that in humans is encoded by the IGHV@ gene. ^{[1] [2] [3]}

IGHV is the immunoglobulin heavy chain variable region genes; in B-cell neoplasms such as chronic lymphocytic leukemia, mutations of IGHV are associated with better response to treatment and longer survival. ^[4]

See also

• IGH@

References

1. Walter MA, Dosch HM, Cox DW (Aug 1991). "A deletion map of the human immunoglobulin heavy chain variable region". J Exp Med. 174 (2): 335–49. doi:10.1084/jem.174.2.335. PMC   2118905 . PMID   1649888.
2. Schroeder HW Jr; Walter MA; Hofker MH; Ebens A; Willems van Dijk K; Liao LC; Cox DW; Milner EC; Perlmutter RM (Dec 1988). "Physical linkage of a human immunoglobulin heavy chain variable region gene segment to diversity and joining region elements". Proc Natl Acad Sci U S A. 85 (21): 8196–200. Bibcode:1988PNAS...85.8196S. doi: 10.1073/pnas.85.21.8196 . PMC   282394 . PMID   3141924.
3. "Entrez Gene: IGHV@ immunoglobulin heavy variable group".^{[ dead link ]}
4. Forconi F, Sozzi E, Cencini E, et al. (November 2009). "Hairy cell leukemias with unmutated IGHV genes define the minor subset refractory to single agent cladribine and with more aggressive behavior". Blood. 114 (21): 4696–4702. doi: 10.1182/blood-2009-03-212449 . PMID   19667403.

Further reading

• Matsuda F, Shin EK, Hirabayashi Y, et al. (1990). "Organization of variable region segments of the human immunoglobulin heavy chain: duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segments". EMBO J. 9 (8): 2501–6. doi:10.1002/j.1460-2075.1990.tb07429.x. PMC   552279 . PMID   2114977.
• Cherif D, Berger R (1991). "New localizations of VH sequences by in situ hybridization with biotinylated probes". Genes Chromosomes Cancer. 2 (2): 103–8. doi:10.1002/gcc.2870020205. PMID   2126193. S2CID   22489747.
• Toyonaga B, Yoshikai Y, Vadasz V, et al. (1986). "Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain". Proc. Natl. Acad. Sci. U.S.A. 82 (24): 8624–8. doi: 10.1073/pnas.82.24.8624 . PMC   390970 . PMID   3866244.
• Matthyssens G, Rabbitts TH (1981). "Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region". Proc. Natl. Acad. Sci. U.S.A. 77 (11): 6561–5. doi: 10.1073/pnas.77.11.6561 . PMC   350325 . PMID   6450418.
• Mariette X, Tsapis A, Brouet JC (1993). "Nucleotidic sequence analysis of the variable domains of four human monoclonal IgM with an antibody activity to myelin-associated glycoprotein". Eur. J. Immunol. 23 (4): 846–51. doi:10.1002/eji.1830230412. PMID   7681398. S2CID   38756102.
• Boursier L, Su W, Spencer J (2003). "Imprint of somatic hypermutation differs in human immunoglobulin heavy and lambda chain variable gene segments". Mol. Immunol. 39 (16): 1025–34. doi:10.1016/S0161-5890(03)00033-6. PMID   12749909.
• Nakamura N, Nakamura S, Yamaguchi M, et al. (2005). "CD5+ diffuse large B-cell lymphoma consists of germline cases and hypermutated cases in the immunoglobulin heavy chain gene variable region". Int. J. Hematol. 81 (1): 58–61. doi:10.1532/IJH97.04119. PMID   15717690. S2CID   22639228.
• Suárez E, Magadán S, Sanjuán I, et al. (2006). "Rearrangement of only one human IGHV gene is sufficient to generate a wide repertoire of antigen specific antibody responses in transgenic mice". Mol. Immunol. 43 (11): 1827–35. doi:10.1016/j.molimm.2005.10.015. PMID   16343622.
• Balogh Z, Reiniger L, Deák L, et al. (2007). "IgVH gene mutation status and genomic imbalances in chronic lymphocytic leukaemia with increased prolymphocytes (CLL/PL)". Hematological Oncology. 25 (2): 90–5. doi:10.1002/hon.812. PMID   17410523. S2CID   19587621.