Ike Opara (born 1989), American Major League Soccer player
Ike Petersen (1909–1995), American National Football League player
Ike Poole (1915–2002), American college basketball player
Ike Rogers (fl.1916-1917, 1919), American college football player
Ike Quartey (born 1969), Ghanaian former boxer and WBA welterweight world champion
Ike Samuels (1874–1964), American Major League Baseball player
Ike Sewell (1903–1990), American college football player and entrepreneur
Ike Shorunmu (born 1967), Nigerian former football goalkeeper
Ike Taylor (born 1980), American retired National Football League player
Ike Tomlinson (1910-2000), American college baseball, basketball and football coach and athletics administrator
Ike Williams (1923-1994), American boxer and NBA lightweight world champion
Ike Woods (1879–1962), Australian rules footballer
Other
Ike Clanton (1847–1887), Old West outlaw present (unarmed) at the Gunfight at the O.K. Corral
Isaac Haxton (born 1985), American professional poker player
Ike Pappas (1933-2008), longtime CBS News correspondent
Fictional characters
Ike (Fire Emblem), the main character in the video games Fire Emblem: Path of Radiance and Fire Emblem: Radiant Dawn, and a playable fighter in Super Smash Bros. Brawl, Super Smash Bros. for Wii U/3DS, and Super Smash Bros. Ultimate.
Ike Broflovski, a recurring character in the animated television series South Park
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