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Christiaan Neethling Barnard was a South African cardiac surgeon who performed the world's first human-to-human heart transplant operation. On 3 December 1967, Barnard transplanted the heart of accident-victim Denise Darvall into the chest of 54-year-old Louis Washkansky, with Washkansky regaining full consciousness and being able to talk easily with his wife, before dying eighteen days later of pneumonia, largely brought on by the anti-rejection drugs that suppressed his immune system. Barnard had told Mr. and Mrs. Washkansky that the operation had an 80% chance of success, an assessment which has been criticised as misleading. Barnard's second transplant patient, Philip Blaiberg, whose operation was performed at the beginning of 1968, lived for a year and a half and was able to go home from the hospital.
In biology, an organ is a collection of tissues joined in a structural unit to serve a common function. In the hierarchy of life, an organ lies between tissue and an organ system. Tissues are formed from same type cells to act together in a function. Tissues of different types combine to form an organ which has a specific function. The intestinal wall for example is formed by epithelial tissue, and smooth muscle tissue. Two or more organs working together in the execution of a specific body function form an organ system, also called a biological system or body system.
Organ transplantation is a medical procedure in which an organ is removed from one body and placed in the body of a recipient, to replace a damaged or missing organ. The donor and recipient may be at the same location, or organs may be transported from a donor site to another location. Organs and/or tissues that are transplanted within the same person's body are called autografts. Transplants that are recently performed between two subjects of the same species are called allografts. Allografts can either be from a living or cadaveric source.
A head transplant is an experimental surgical operation involving the grafting of one organism's head onto the body of another. In many experiments, the recipient's head has not been removed, but in others it has been. Experimentation in animals began in the early 1900s. As of 2021, no lasting successes have been achieved.
An artificial heart is a device that replaces the heart. Artificial hearts are typically used to bridge the time to heart transplantation, or to permanently replace the heart in the case that a heart transplant is impossible. Although other similar inventions preceded it from the late 1940s, the first artificial heart to be successfully implanted in a human was the Jarvik-7 in 1982, designed by a team including Willem Johan Kolff, William DeVries and Robert Jarvik.
Transplant rejection occurs when transplanted tissue is rejected by the recipient's immune system, which destroys the transplanted tissue. Transplant rejection can be lessened by determining the molecular similitude between donor and recipient and by use of immunosuppressant drugs after transplant.
A heart–lung transplant is a procedure carried out to replace both heart and lungs in a single operation. Due to a shortage of suitable donors and due to the fact that both heart and lung have to be transplanted together, it is a rare procedure; only about a hundred such transplants are performed each year in the United States.
Cardiac surgery, or cardiovascular surgery, is surgery on the heart or great vessels performed by cardiac surgeons. It is often used to treat complications of ischemic heart disease ; to correct congenital heart disease; or to treat valvular heart disease from various causes, including endocarditis, rheumatic heart disease, and atherosclerosis. It also includes heart transplantation.
Jonathan Paul "J. P." Losman is an American football coach and former quarterback who is currently the senior offensive analyst at Clemson University. Losman played in the National Football League for seven seasons, primarily with the Buffalo Bills. He played college football at UCLA and Tulane and was drafted by the Bills in the first round in the 2004 NFL Draft.
The Toronto General Hospital (TGH) is a major teaching hospital in Toronto, Ontario, Canada and the flagship campus of University Health Network (UHN). It is located in the Discovery District of Downtown Toronto along University Avenue's Hospital Row; it is directly north of The Hospital for Sick Children, across Gerrard Street West, and east of Princess Margaret Cancer Centre and Mount Sinai Hospital. The hospital serves as a teaching hospital for the University of Toronto Faculty of Medicine. In 2021, Newsweek ranked TGH as the 4th best hospital in the world and 1st in Canada. In 2019, the hospital was ranked first for research in Canada by Research Infosource for the ninth consecutive year.
Organ procurement is a surgical procedure that removes organs or tissues for reuse, typically for organ transplantation.
Dale Gunnar Renlund is an American religious leader and former cardiologist who serves in the Quorum of the Twelve Apostles of The Church of Jesus Christ of Latter-day Saints. He has been a general authority of the church since 2009. Currently, he is the thirteenth most senior apostle in the church.
Norman Edward Shumway was a pioneer of heart surgery at Stanford University. He was the 67th president of the American Association for Thoracic Surgery and the first to perform an adult human to human heart transplantation in the United States.
A heart transplant, or a cardiac transplant, is a surgical transplant procedure performed on patients with end-stage heart failure or severe coronary artery disease when other medical or surgical treatments have failed. As of 2018, the most common procedure is to take a functioning heart, with or without both lungs, from a recently deceased organ donor and implant it into the patient. The patient's own heart is either removed and replaced with the donor heart or, much less commonly, the recipient's diseased heart is left in place to support the donor heart.
ABO-incompatible (ABOi) transplantation is a method of allocation in organ transplantation that permits more efficient use of available organs regardless of ABO blood type, which would otherwise be unavailable due to hyperacute rejection. Primarily in use in infants and young toddlers, research is ongoing to allow for increased use of this capability in adult transplants. Normal ABO-compatibility rules may be observed for all recipients. This means that anyone may receive a transplant of a type-O organ, and consequently, type-O recipients are one of the biggest beneficiaries of ABO-incompatible transplants. While focus has been on infant heart transplants, the principles generally apply to other forms of solid organ transplantation.
Sir Terence Alexander Hawthorne English is a South African-born British retired cardiac surgeon. He was Consultant Cardiothoracic Surgeon, Papworth Hospital and Addenbrooke's Hospital, Cambridge, 1973–1995. After starting a career in mining engineering, English switched to medicine and went on to lead the team that performed Britain's first successful heart transplant in August 1979 at Papworth, and soon established it as one of Europe's leading heart–lung transplant programmes.
Christian Emile Cabrol was a French cardiac surgeon best known for performing Europe's first heart transplant at Pitié-Salpêtrière Hospital in 1968.
The Trillium Gift of Life Network was an agency of the Government of Ontario responsible for the province's organ donation strategy, promotion, and supply. Ronnie Gavsie was the President & CEO. The agency maintained the popular BeADonor.ca website. It was subsequently subsumed under Ontario Health in 2019.
The International Society for Heart and Lung Transplantation (ISHLT), established in 1981, is a professional organization committed to research and education in heart and lung disease and transplantation. It holds annual scientific meetings and publishes The Journal of Heart and Lung Transplantation. It also holds the largest registry of heart and lung transplant data in the world, of which one former director was Michael Peter Kaye (1983–1993).
Michael Peter Kaye was an American surgeon and researcher who co-founded the International Society for Heart and Lung Transplantation (ISHLT) in 1981. He developed the society's registry and edited the Journal of Heart and Lung Transplantation.
References
- ↑ Our Doctors: Jacques G. Losman, MD. Center for Wound Healing & Hyperbaric Medicine. Retrieved 9 September 2018.
- ↑ ISHLT 2017 Final Program. CTI Meeting Technology. 2017. pp. 61–62. GGKEY:YQETT77DRT5.
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