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Leukemia, also spelled leukaemia, is a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells. These blood cells are not fully developed and are called blasts or leukemia cells. Symptoms may include bleeding and bruising, feeling tired, fever, and an increased risk of infections. These symptoms occur due to a lack of normal blood cells. Diagnosis is typically made by blood tests or bone marrow biopsy.
Bone marrow is a semi-solid tissue which may be found within the spongy or cancellous portions of bones. In birds and mammals, bone marrow is the primary site of new blood cell production or hematopoiesis. It is composed of hematopoietic cells, marrow adipose tissue, and supportive stromal cells. In adult humans, bone marrow is primarily located in the ribs, vertebrae, sternum, and bones of the pelvis. Bone marrow comprises approximately 5% of total body mass in healthy adult humans, such that a man weighing 73 kg will have around 3.65 kg of bone marrow.
Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood. It may be autologous, allogeneic or syngeneic.
The myeloproliferative neoplasms (MPNs), previously myeloproliferative diseases (MPDs), are a group of diseases of the bone marrow in which excess cells are produced. They are related to, and may evolve into, myelodysplastic syndrome and acute myeloid leukemia, although the myeloproliferative diseases on the whole have a much better prognosis than these conditions. The concept of myeloproliferative disease was first proposed in 1951 by the hematologist William Dameshek. In the most recent World Health Organization classification of hematologic malignancies, this group of diseases was renamed from "myeloproliferative diseases" to "myeloproliferative neoplasms". This reflects the underlying clonal genetic changes that are a salient feature of this group of disease.
Dana–Farber Cancer Institute is a comprehensive cancer treatment and research institution in Boston, Massachusetts. Dana-Farber is the founding member of Dana–Farber/Harvard Cancer Center, Harvard's Comprehensive Cancer Center designated by the National Cancer Institute, and one of the 15 clinical affiliates and research institutes of Harvard Medical School.
Acute erythroid leukemia is a rare form of acute myeloid leukemia where the myeloproliferation is of erythroblastic precursors. It is defined as type "M6" under the FAB classification.
Craig Graham Sager Sr. was an American sports reporter, covering, from 1981 until the year of his death, an array of sports for CNN and its sister stations, TBS and TNT.
Jim Donovan is an American radio and television personality who serves as sports director and news anchor for WKYC channel 3 (NBC) in Cleveland, Ohio, and has been the radio voice of the Cleveland Browns Radio Network since 1999.
Michael Leslie "Mike" Peters is a Welsh musician, best known as the lead singer of the Alarm. After the band split up in 1991, Peters wrote and released solo work, before reconstituting the Alarm in 2000. Additionally, he is co-founder of the Love Hope Strength Foundation. Between 2011 and 2013, Peters was the vocalist for Big Country as well as The Alarm.
Acute myeloblastic leukemia with maturation (M2) is a subtype of acute myeloid leukemia (AML).
Precursor B-cell lymphoblastic leukemia is a form of lymphoid leukemia in which too many B-cell lymphoblasts are found in the blood and bone marrow. It is the most common type of acute lymphoblastic leukemia (ALL). It is sometimes additionally classified as a lymphoma, as designated leukemia/lymphoma.
Robert Peter Gale is an American physician and medical researcher. He is known for research in leukemia and other bone marrow disorders.
Love Hope Strength Foundation is a charitable foundation whose purpose is to raise funds and awareness in order to benefit people with cancer and leukaemia. The charity sponsors treks and climbs to the world's highest mountains, often performing musical concerts at the peak.
The Gift of Life Marrow Registry is a public bone marrow and blood stem cell registry headquartered in Boca Raton, Florida. Gift of Life facilitates transplants for children and adults suffering from life-threatening illnesses, including leukemia, lymphoma, other cancers and genetic diseases.
The fifth season of Supernatural, an American dark fantasy television series created by Eric Kripke, premiered September 10, 2009, and concluded on May 13, 2010, on The CW. Season five regular cast members include Jared Padalecki, Jensen Ackles and Misha Collins, who was promoted to series regular this season. After the conclusion of this season, series creator Eric Kripke stepped down as showrunner. The fifth season was released on DVD and Blu-ray in region 1 on September 7, 2010. The season follows Sam and Dean as they set out to take down Lucifer, whom Sam had inadvertently released from Hell at the end of the previous season.
Stewart Francke is a singer/musician/songwriter in Detroit.
Childhood leukemia is leukemia that occurs in a child and is a type of childhood cancer. Childhood leukemia is the most common childhood cancer, accounting for 29% of cancers in children aged 0–14 in 2018. There are multiple forms of leukemia that occur in children, the most common being acute lymphoblastic leukemia (ALL) followed by acute myeloid leukemia (AML). Survival rates vary depending on the type of leukemia, but may be as high as 90% in ALL.
Mandi Jocelyn Schwartz was a Canadian ice hockey player with the Yale Bulldogs. She was a three time Eastern College Athletic Conference (ECAC) Hockey All-Academic, and played 73 consecutive games with the team before being diagnosed with acute myeloid leukemia in December 2008. Prior to joining Yale University, Schwartz had played minor hockey for Athol Murray College of Notre Dame in Saskatchewan. Her younger brother, Jaden currently plays for the St. Louis Blues in the National Hockey League.
Michelle Kim Maykin was a well-known figure in the Asian American community who promoted ethnic participation in the national marrow registry, the National Marrow Donor Program. Suffering from acute myeloid leukemia herself, she began a personal search for a bone marrow donor and began the internationally noted campaign, Project Michelle, which was able to register more than 18,000 people as well as find matches for 4 different patients. Unable to find a match herself, she died on July 25, 2009.
DKMS is an international nonprofit bone marrow donor center based in Tübingen, Germany with entities in the US, UK, Chile, Poland, and India. DKMS works in the areas of blood cancer and hematopoietic stem cell transplantation and raises awareness of the need for donors for hematopoietic stem cell transplantation which people with blood cancers need for treatment as well as helping people sign up to their national bone marrow registries. Over the years, DKMS has expanded beyond Germany.
References
- 1 2 Kripke, Pamela Gwyn (15 September 2008). "Preparing For The Worst". American Way . Archived from the original on 17 July 2009. Retrieved 6 February 2009.
- 1 2 3 4 Kripke, Pamela Gwyn (November 9, 2008). "A World Away, Finding a Lifeline and a Friend". New York Times . Retrieved October 6, 2011.
- ↑ "Editorial: Life-saving gift". Dallas News.com. Dallas Morning News. Archived from the original on February 2, 2009. Retrieved 6 February 2009.
- ↑ "Alarm Singer Aims High With Tour". BBC News Wales. BBC. 12 March 2007. Retrieved 6 February 2009.
- ↑ "Love, Hope, Strength and Last Call". NBC DFW. 8 July 2010. Retrieved 31 October 2011.
- ↑ http://www.lovehopestrength.org/site/james-chippendale/