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Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, and metabolism. Over the last decades of the 20th century, biochemistry has become successful at explaining living processes through these three disciplines. Almost all areas of the life sciences are being uncovered and developed through biochemical methodology and research. Biochemistry focuses on understanding the chemical basis which allows biological molecules to give rise to the processes that occur within living cells and between cells, in turn relating greatly to the understanding of tissues and organs as well as organism structure and function. Biochemistry is closely related to molecular biology, the study of the molecular mechanisms of biological phenomena.
Molecular biology is a branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions.
Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations. Biophysical research shares significant overlap with biochemistry, molecular biology, physical chemistry, physiology, nanotechnology, bioengineering, computational biology, biomechanics, developmental biology and systems biology.
Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and cell parts. The word "biochemist" is a portmanteau of "biological chemist."
In biochemistry and molecular biology, a binding site is a region on a macromolecule such as a protein that binds to another molecule with specificity. The binding partner of the macromolecule is often referred to as a ligand. Ligands may include other proteins, enzyme substrates, second messengers, hormones, or allosteric modulators. The binding event is often, but not always, accompanied by a conformational change that alters the protein's function. Binding to protein binding sites is most often reversible, but can also be covalent reversible or irreversible.
The Max Planck Institute of Biochemistry is a research institute of the Max Planck Society located in Martinsried, a suburb of Munich. The institute was founded in 1973 by the merger of three formerly independent institutes: the Max Planck Institute of Biochemistry, the Max Planck Institute of Protein and Leather Research, and the Max Planck Institute of Cell Chemistry.
The Journal of Biological Chemistry (JBC) is a weekly peer-reviewed scientific journal that was established in 1905. Since 1925, it is published by the American Society for Biochemistry and Molecular Biology. It covers research in areas of biochemistry and molecular biology. The editor is Alex Toker. As of January 2021, the journal is fully open access. In press articles are available free on its website immediately after acceptance.
The L'Oréal-UNESCO For Women in Science International Awards, created in 1998, aim to improve the position of women in science by recognizing outstanding women researchers who have contributed to scientific progress. The awards are a result of a partnership between the Foundation of the French company L'Oréal and the United Nations Educational, Scientific and Cultural Organization (UNESCO) and carry a grant of $100,000 USD for each laureate. This award is also known as the L'Oréal-UNESCO Women in Science Awards.
The American Society for Biochemistry and Molecular Biology (ASBMB) is a learned society that was founded on December 26, 1906, at a meeting organized by John Jacob Abel. The roots of the society were in the American Physiological Society, which had been formed some 20 years earlier. ASBMB is the US member of the International Union of Biochemistry and Molecular Biology.
Franz-Ulrich Hartl is a German biochemist and the current Executive Director of the Max Planck Institute of Biochemistry. He is known for his pioneering work in chaperone-mediated protein folding.
Charles Tanford was a German-born protein biochemist. He died in York, England, on October 1, 2009.
Joseph Stewart Fruton, born Joseph Fruchtgarten, was a Polish-American biochemist and historian of science. His most significant scientific work involved synthetic peptides and their interactions with proteases; with his wife Sofia Simmonds he also published an influential textbook, General Biochemistry. From 1970 until his death, Fruton worked extensively on the history of science, particularly the history of biochemistry and molecular biology.
In molecular biology, binding domain is a protein domain which binds to a specific atom or molecule, such as calcium or DNA. A protein domain is a part of a protein sequence and a tertiary structure that can change or evolve, function, and live by itself independent of the rest of the protein chain. Upon binding, proteins may undergo a conformational change. Binding domains are essential for the function of many proteins. They are essential because they help splice, assemble, and translate proteins.
Scott D. Emr is an American cell biologist and the founding and current Director of the Weill Institute for Cell and Molecular Biology at Cornell University, where he is also a Frank H.T. Rhodes Class of 1956 Professor at the Department of Molecular Biology and Genetics.
Harry F. Noller is an American biochemist, and since 1992 the director of the University of California, Santa Cruz's Center for the Molecular Biology of RNA. He has made significant contributions to our understanding of the ribosome and is a member of the National Academy of Sciences.
Alanna Schepartz is an American professor and scientist. She is currently the T.Z. and Irmgard Chu Distinguished Chair in Chemistry at University of California, Berkeley. She was formerly the Sterling Professor of Chemistry at Yale University.
Sheena Elizabeth Radford is a British biophysicist, and Astbury Professor of Biophysics and a Royal Society Research Professor in the Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology at the University of Leeds. Radford is the Associate Editor of the Journal of Molecular Biology.
James Hurley is a university professor known for his research into proteins. He won the 2014 Neurath Award from the Protein Society for a unique, recent contribution to basic science.
Robert L. Hill (1928-2012) was a biochemist who spent most of his career on the faculty at Duke University School of Medicine, from which he retired as the James B. Duke Professor Emeritus. Hill's research focused on the chemistry of enzymes, with particular specialization in glycosyltransferases and glycobiology.
Barry H. Honig is an American biochemist, molecular biophysicist, and computational biophysicist, who develops theoretical methods and computer software for "analyzing the structure and function of biological macromolecules."
References
- ↑ "James Sodetz". aaas.org. Retrieved May 12, 2017.
- ↑ "James Sodetz". sc.edu. Retrieved May 12, 2017.
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