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A zoonosis or zoonotic disease is an infectious disease of humans caused by a pathogen that can jump from a non-human vertebrate to a human. When humans infect non-humans, it is called reverse zoonosis or anthroponosis.
An epidemic is the rapid spread of disease to a large number of hosts in a given population within a short period of time. For example, in meningococcal infections, an attack rate in excess of 15 cases per 100,000 people for two consecutive weeks is considered an epidemic.
Disease is described as a decrease in performance of normal functions of an individual caused by many factors, which is not limited to infectious agents. Furthermore, wildlife disease is a disease when one of the hosts includes a wildlife species. In many cases, wildlife hosts can act as a reservoir of diseases that spillover into domestic animals, people and other species. Wildlife diseases spread through both direct contact between two individual animals or indirectly through the environment. Additionally, human industry has created the possibility for cross-species transmission through the wildlife trade.Furthermore, there are many relationships that must be considered when discussing wildlife disease, which are represented through the Epidemiological Triad Model. This model describes the relationship between a pathogen, host and the environment. There are many routes to infection of a susceptible host by a pathogen, but when the host becomes infected that host now has the potential to infect other hosts. Whereas, environmental factors affect pathogen persistence and spread through host movement and interactions with other species. An example to apply to the ecological triad is Lyme disease, where changes in environment have changed the distribution of Lyme disease and its vector, the Ixodes tick. The recent increase in wildlife disease occurrences is cause for concern among conservationists, as many vulnerable species do not have the population to recover from devastating disease outbreaks.
Alessandro Vespignani is an Italian-American physicist, best known for his work on complex networks, and particularly for work on the applications of network theory to the mathematical modeling of infectious disease, applications of computational epidemiology, and for studies of the topological properties of the Internet. He is currently the Sternberg Family Distinguished University Professor of Physics, Computer Science and Health Sciences at Northeastern University, where he is the director of the Network Science Institute.
Bryan Thomas Grenfell is a British population biologist and the Kathryn Briger and Sarah Fenton Professor of Ecology and Evolutionary Biology and Public Affairs at the Princeton School of Public and International Affairs at Princeton University.
Peter John Morland Openshaw, is a British clinician and scientist specialising in lung immunology, particularly defence against viral infections. He trained in lung diseases and undertook a PhD in immunology before establishing a laboratory at St Mary's Hospital Medical School. He created the academic department of Respiratory Medicine and the Centre for Respiratory Infection at Imperial College and was elected President of the British Society for Immunology in 2014.
Spillover infection, also known as pathogen spillover and spillover event, occurs when a reservoir population with a high pathogen prevalence comes into contact with a novel host population. The pathogen is transmitted from the reservoir population and may or may not be transmitted within the host population. Due to climate change and land use expansion, the risk of viral spillover is predicted to significantly increase.
Lalita Ramakrishnan is an Indian-born American microbiologist who is known for her contributions to the understanding of the biological mechanism of tuberculosis. As of 2019 she serves as a professor of Immunology and Infectious Diseases at the University of Cambridge, where she is also a Wellcome Trust Principal Research Fellow and a practicing physician. Her research is conducted at the MRC Laboratory of Molecular Biology, where she serves as the Head of the Molecular Immunity Unit of the Department of Medicine embedded at the MRC LMB. Working with Stanley Falkow at Stanford, she developed the strategy of using Mycobacterium marinum infection as a model for tuberculosis. Her work has appeared in a number of journals, including Science, Nature, and Cell. In 2018 and 2019 Ramakrishnan coauthored two influential papers in the British Medical Journal (BMJ) arguing that the widely accepted estimates of the prevalence of latent tuberculosis—estimates used as a basis for allocation of research funds—are far too high. She is married to Mark Troll, a physical chemist.
Christl Ann Donnelly is a professor of statistical epidemiology at Imperial College London, the University of Oxford and a Fellow of St Peter's College, Oxford. She serves as associate director of the MRC Centre for Global Infectious Disease Analysis. In 2022, Donnelly was appointed Head of the Department of Statistics, University of Oxford.
David Arnold Relman is an American microbiologist and the Thomas C. and Joan M. Merigan Professor in Medicine, and in Microbiology & Immunology at the Stanford University School of Medicine. His research focuses on the human microbiome and microbial ecosystem—for which he was a pioneer in the use of modern molecular methods, as well as on pathogen discovery and the genomics of host response.
Guan Yi is a Chinese virologist. In 2014, he was ranked as 11th in the world by Thomson Reuters among global researchers in the field of microbiology. He obtained his PhD in microbiology at the University of Hong Kong and is now a professor of microbiology at his alma mater. His research on the viral respiratory disease SARS helped the Chinese government avert the 2004 outbreak of this disease. He is the current director of the State Key Laboratory for Emerging Infectious Diseases University of Hong Kong. In early 2017, Guan warned that the H7N9 influenza virus "poses the greatest threat to humanity than any other in the past 100 years".
Julia Rose Gog is a British mathematician and professor of mathematical biology in the faculty of mathematics at the University of Cambridge. She is also a David N. Moore fellow, director of studies in mathematics at Queens' College, Cambridge and a member of both the Cambridge immunology network and the infectious diseases interdisciplinary research centre.
Neil Morris Ferguson is a British epidemiologist and professor of mathematical biology, who specialises in the patterns of spread of infectious disease in humans and animals. He is the director of the Jameel Institute, and of the MRC Centre for Global Infectious Disease Analysis, and head of the Department of Infectious Disease Epidemiology in the School of Public Health and Vice-Dean for Academic Development in the Faculty of Medicine, all at Imperial College London.
François Balloux is the director of the UCL Genetics Institute, and a professor of computational biology at University College London.
Cécile Viboud is a Staff Scientist based in the Fogarty International Center at the National Institutes of Health, where she is part of the Multinational Influenza Seasonal Mortality Study (MISMS). Viboud specialises in the mortality of infectious disease. Viboud was involved with epidemiological analysis during the COVID-19 pandemic.
Saskia Popescu is an infectious disease epidemiologist and global health security expert in Phoenix, Arizona. She is an Assistant Professor of epidemiology at the University of Maryland, and holds academic appointments at the University of Arizona and George Mason University’s Schar School of Policy and Government, where she lectures on biopreparedness and outbreak response. Since the start of the Coronavirus disease 2019 pandemic, Popescu has worked to prepare for and mitigate the spread of the disease within healthcare and the entertainment industry, where she led the global epidemiology and infection prevention response for Netflix. She has been recognized for her communication efforts around the pandemic, as well as her work on the front lines in infection prevention and healthcare biopreparedness. Popescu currently is a Policy Researcher at RAND Corporation, addressing converging biological risks from biological weapons nonproliferation, biosecurity, emerging infectious diseases and ecological security, biopreparedness in private industry, and global health security vulnerabilities.
David Hayman is a New Zealand-based epizootic epidemiologist and disease ecologist whose general multi-disciplinary work focuses on the maintenance of infectious diseases within their hosts and the process of emergence and transmission to humans specifically related to bats. He has gathered data on the relationship between ecological degradation due to anthropogenic actions, and increased pathogen emergence in humans and animals. During COVID-19 he was involved as an expert in several international collaborations, some convened by the World Health Organization, and was a regular commentator in the New Zealand media about the country's response to the pandemic. He has had lead roles in research organisations at Massey University and Te Pūnaha Matatini and was the recipient of the 2017 Rutherford Discovery Fellowship Award. Since 2014 Hayman has been a professor at Massey University.
Maria Vanessa Sancho Shimizu is a UKRI Future Leaders Fellow and Reader in the sections of Paediatrics Infectious Diseases and Virology investigating the human genetic basis of life-threatening infections.
Katerina Heran Darwin is an American microbiologist and professor of microbiology at New York University Grossman School of Medicine. Her research interests include the bacterial proteasome and the antimicrobial effects of host-produced effectors including nitric oxide, copper, and aldehydes
Jordan L. Peccia is an American engineer and Professor of Environmental Engineering at Yale University. He was born in Cut Bank, MT. Since 2005, Peccia has been a member of the Chemical and Environmental Engineering faculty at Yale University, where he holds the Thomas E. Golden endowed professorship., and serves as the department's Chair. He is an elected member of the Connecticut Academy of Science and Engineering. In 2023, Peccia was named Head of Yale’s Benjamin Franklin College.
References
- ↑ Gallagher, James. "Covid origins: Genetic ghosts suggest pandemic started in market". BBC News . Archived from the original on 5 October 2024. Retrieved 2024-09-19.
- ↑ "James Wood". Wolfson College, Cambridge. Archived from the original on 5 October 2024. Retrieved 2024-09-19.
- ↑ "Prof James Wood". Professionals. Royal College of Vetinary Surgeons. Retrieved 5 October 2024.
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