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Mary-Claire King is an American geneticist. She was the first to show that breast cancer can be inherited due to mutations in the gene she called BRCA1. She studies human genetics and is particularly interested in genetic heterogeneity and complex traits. She studies the interaction of genetics and environmental influences and their effects on human conditions such as breast and ovarian cancer,inherited deafness,schizophrenia,HIV,systemic lupus erythematosus and rheumatoid arthritis. She has been the American Cancer Society Professor of the Department of Genome Sciences and of Medical Genetics in the Department of Medicine at the University of Washington since 1995.
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Pseudoexfoliation syndrome,often abbreviated as PEX and sometimes as PES or PXS,is an aging-related systemic disease manifesting itself primarily in the eyes which is characterized by the accumulation of microscopic granular amyloid-like protein fibers. Its cause is unknown,although there is speculation that there may be a genetic basis. It is more prevalent in women than men,and in persons past the age of seventy. Its prevalence in different human populations varies;for example,it is prevalent in Scandinavia. The buildup of protein clumps can block normal drainage of the eye fluid called the aqueous humor and can cause,in turn,a buildup of pressure leading to glaucoma and loss of vision. As worldwide populations become older because of shifts in demography,PEX may become a matter of greater concern.
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References
- 1 2 "Dr. Wiggs Is the Bride Of Dr. Eric Schreiber". The New York Times. October 20, 1986. Retrieved November 12, 2019.
- ↑ "How One Lecture Is Influencing Glaucoma Research: Janey Wiggs '76, Ph.D. '81". alumni.berkeley.edu. 6 May 2019. Retrieved November 12, 2019.
- ↑ "Eye Witness Newsletter #34". August 14, 2017. pp. 8–9. Retrieved September 20, 2020.
- ↑ Wigss J; Nordenskjold M; Yandell D; Rapaport J; Grondin V; Janson M; Werelius B; Petersen R; Craft A; Riedel K (1988). "Prediction of the risk of hereditary retinoblastoma, using DNA polymorphisms within the retinoblastoma gene". New England Journal of Medicine. 318 (3): 151–157. doi:10.1056/NEJM198801213180305. PMID 2892131.
- ↑ "Dr. Wiggs Inducted into AOI". oculargenomics.meei.harvard.edu. May 1, 2017. Retrieved November 12, 2019.
- ↑ "Researchers discover three glaucoma-related genes". nih.gov. January 11, 2016. Retrieved November 12, 2019.
- ↑ "Three New Glaucoma-related Genes Identified". eye.hms.harvard.edu. January 12, 2018. Retrieved November 12, 2019.
- ↑ Harrison, Lair (February 2, 2019). "Glaucoma genetics working toward a cure". ophthalmologytimes.com. Archived from the original on June 4, 2019. Retrieved November 12, 2019.
- ↑ "Janey L. Wiggs, MD, PhD, FARVO". glaucomafoundation.org. Retrieved November 12, 2019.
- ↑ "Wiggs and Collantes receive 2018 Dr. David L. Epstein Award". arvo.org. 2018. Retrieved November 12, 2019.
- ↑ "Janey L. Wiggs, MD, PhD, Elected to the National Academy of Medicine". masseyeandear.org. October 15, 2018. Retrieved November 11, 2019.
