Joanne Gignilliat Trimmier Woodward is an American actress. A star since the Golden Age of Hollywood, Woodward made her career breakthrough in the 1950s and earned esteem and respect playing complex women with a characteristic nuance and depth of character. She is one of the first film stars to have an equal presence in television. Her accolades include an Academy Award, three Primetime Emmy Awards, a British Academy Film Award, three Golden Globe Awards, and a Screen Actors Guild Award. She is one of the last surviving stars from the Golden Age of Hollywood cinema and the oldest living Best Actress Oscar-winner.
Maria Owings Shriver is an American journalist, author, a member of the Kennedy family, former First Lady of California, and the founder of the nonprofit organization The Women's Alzheimer's Movement. She was married to former governor of California and actor Arnold Schwarzenegger, from whom she filed for divorce in 2011 and which was finalized in 2021.
Biogen Inc. is an American multinational biotechnology company based in Cambridge, Massachusetts, specializing in the discovery, development, and delivery of therapies for the treatment of neurological diseases to patients worldwide.
Donepezil, sold under the brand name Aricept among others, is a medication used to treat dementia of the Alzheimer's type. It appears to result in a small benefit in mental function and ability to function. Use, however, has not been shown to change the progression of the disease. Treatment should be stopped if no benefit is seen. It is taken by mouth or via a transdermal patch.
Coste is a surname. Notable people with the surname include:
Hazel Susan Hawke, AO was the first wife of Bob Hawke, the 23rd Prime Minister of Australia. She married him in 1956, and supported him throughout his prime ministership (1983–1991); they divorced in 1995. She worked in social policy areas, and was an amateur pianist and a patron of the arts. After she was diagnosed with Alzheimer's disease, she made public appearances in order to raise awareness of the disease.
Memantine is a medication used to slow the progression of moderate-to-severe Alzheimer's disease. It is taken by mouth.
Princess Yasmin Aga Khan is a Swiss-born American philanthropist known for raising public awareness of Alzheimer's disease.
Vernon Martin Ingram, was a German–American professor of biology at the Massachusetts Institute of Technology.
Apolipoprotein E (Apo-E) is a protein involved in the metabolism of fats in the body of mammals. A subtype is implicated in the Alzheimer's disease and cardiovascular diseases. It is encoded in humans by the gene APOE.
scyllo-Inositol is one of the stereoisomers of inositol. It is also known as scyllitol, cocositol, quercinitol, and 1,3,5/2,4,6-hexahydroxycyclohexane. scyllo-Inositol is a naturally occurring plant sugar alcohol found most abundantly in the coconut palm.
Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As the disease advances, symptoms can include problems with language, disorientation, mood swings, loss of motivation, self-neglect, and behavioral issues. As a person's condition declines, they often withdraw from family and society. Gradually, bodily functions are lost, ultimately leading to death. Although the speed of progression can vary, the typical life expectancy following diagnosis is three to nine years.
I Remember Better When I Paint is a feature length international documentary film about the positive impact of art and other creative therapies in people with Alzheimer's disease and how these approaches can change the way the disease is viewed by society. The film examines the way creative arts bypass the limitations of dementia disorders such as Alzheimer's and shows how patients' still-vibrant imaginations are strengthened through therapeutic art.
Trish Vradenburg was an American playwright, author, television writer, and advocate of research to cure Alzheimer's disease.
Cymserine is a drug related to physostigmine, which acts as a reversible cholinesterase inhibitor, with moderate selectivity (15×) for the plasma cholinesterase enzyme butyrylcholinesterase, and relatively weaker inhibition of the better-known acetylcholinesterase enzyme. This gives it a much more specific profile of effects that may be useful for treating Alzheimer's disease without producing side effects such as tremors, lacrimation, and salivation that are seen with the older nonselective cholinesterase inhibitors currently used for this application, such as donepezil. A number of cymserine derivatives have been developed with much greater selectivity for butyrylcholinesterase, and both cymserine and several of its analogues have been tested in animals, and found to increase brain acetylcholine levels and produce nootropic effects, as well as reducing levels of amyloid precursor protein and amyloid beta, which are commonly used biomarkers for the development of Alzheimer's disease.
Laurie Hollis Glimcher is an American physician-scientist who was appointed president and CEO of Dana–Farber Cancer Institute in October 2016. She was elected a Member of the American Philosophical Society in 2019.
Ann McKee is a neuropathologist and expert in neurodegenerative disease at the New England Veterans Affairs Medical Centers (VISN-1) and is professor of neurology and pathology at Boston University School of Medicine and director of Boston University CTE Center. She is particularly known for her work studying Alzheimer's disease and the consequences of repetitive traumatic brain injury. In 2017, she was named "Bostonian of the Year" by The Boston Globe for her leading work in this area, and in 2018, Time named McKee one of its 100 most influential people.
Still Alice is a 2014 American drama film written and directed by Richard Glatzer and Wash Westmoreland and based on the 2007 novel by Lisa Genova. It stars Julianne Moore as Alice Howland, a linguistics professor diagnosed with familial Alzheimer's disease shortly after her 50th birthday. Alec Baldwin plays her husband, John, and Kristen Stewart, Kate Bosworth, and Hunter Parrish play her children.
Still Alice is a 2007 novel by Lisa Genova, a neuroscientist and author. The novel is about a woman who suffers early-onset Alzheimer's disease. Alice Howland, a 50-year-old woman, is a cognitive psychology professor at Harvard University and is a world-renowned linguistics expert. She is married to an equally successful husband, and they have three grown children. The disease takes hold swiftly, and it changes Alice's relationship with her family and the world. It is Genova's first novel.
Virginia Man-Yee Lee is a Chinese-born American biochemist and neuroscientist who specializes in the research of Alzheimer's disease. She is the current John H. Ware 3rd Endowed Professor in Alzheimer's Research at the Department of Pathology and Laboratory Medicine, and the director of the Center for Neurodegenerative Disease Research and co-director of the Marian S. Ware Alzheimer Drug Discovery Program at the Perelman School of Medicine, University of Pennsylvania. She received the 2020 Breakthrough Prize in Life Sciences.
