Johannes Kornhuber

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Johannes Kornhuber
Johannes Kornhuber.jpg
Kornhuber in 2014
Born (1959-09-11) 11 September 1959 (age 65)
Occupation(s) Psychiatrist and Psychotherapist

Johannes Kornhuber (born 11 September 1959) is a German psychiatrist and psychotherapist.

Contents

Work

His research interests include the pathophysiology of Alzheimer’s disease, the early diagnosis and treatment of dementia syndromes, the pathophysiology of alcohol addiction and the pathophysiology of major depressive disorder. He has authored or co-authored more than 400 Journal articles. Kornhuber described novel molecular mechanisms of approved psychotropic drugs, namely that memantine, amantadine, budipine and orphenadrine act as low-affinity NMDA-receptor antagonists. [1] [2] The data obtained with memantine formed an important basis for its worldwide approval as an antidementive drug. Kornhuber developed the pharmacokinetic hypothesis explaining the delayed therapeutic effects of antidepressant drugs. [3] Furthermore, he found that antidepressant drugs like amitriptyline and fluoxetine mediate their effects on neurogenesis and behavior by lowering ceramide abundance in the brain. [4] [5] Among his coauthors has been Peter Riederer.[ citation needed ]

Honors

References

  1. Kornhuber J, Bormann J, et al. Memantine displaces [3H]MK-801 at therapeutic concentrations in postmortem human frontal cortex. In: European Journal of Pharmacology . 166:589-590,1989, PMID   2680528
  2. Kornhuber J, Weller M Psychotogenicity and NMDA receptor antagonism: implications for neuroprotective pharmacotherapy. In: Biological Psychiatry . 41:135-144,1997, PMID   9018383
  3. Kornhuber J, Retz W, Riederer P. Slow accumulation of psychotropic substances in the human brain. Relationship to therapeutic latency of neuroleptic and antidepressant drugs? In: Journal of Neural Transmission. Suppl. 46:311-319,1995, PMID   8821068
  4. Gulbins E, Palmada M, et al. Acid sphingomyelinase/ceramide system mediates effects of antidepressant drugs. In: Nature Medicine . 19:934-938,2013, PMID   23770692
  5. Kornhuber J, Müller CP, et al. The ceramide system as a novel antidepressant target. In: Trends in Pharmacological Sciences . 35:293-304,2014, PMID   24793541