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Hyperparathyroidism is an increase in parathyroid hormone (PTH) levels in the blood. This occurs from a disorder either within the parathyroid glands or as response to external stimuli. Symptoms of hyperparathyroidism are caused by inappropriately normal or elevated blood calcium excreted from the bones and flowing into the blood stream in response to increased production of parathyroid hormone. In healthy people, when blood calcium levels are high, parathyroid hormone levels should be low. With long-standing hyperparathyroidism, the most common symptom is kidney stones. Other symptoms may include bone pain, weakness, depression, confusion, and increased urination. Both primary and secondary may result in osteoporosis.
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Paricalcitol (chemically it is 19-nor-1,25-(OH)2-vitamin D2. Marketed by Abbott Laboratories under the trade name Zemplar) is a drug used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic kidney failure. It is an analog of 1,25-dihydroxyergocalciferol, the active form of vitamin D2 (ergocalciferol).
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References
- 1 2 "Honours and Awards". The Gazette. 5 August 2014. Retrieved 9 September 2014.
- 1 2 ‘CUNNINGHAM, Prof. John’, Who's Who 2017, A & C Black, an imprint of Bloomsbury Publishing plc, 2017
- 1 2 3 4 "Professor John Cunningham – At the Limits". www.atthelimits.org. Retrieved 29 January 2022.
- ↑ Professor John Cunningham Archived October 4, 2013, at the Wayback Machine
- ↑ Malvern, Jack. "Duke of Edinburgh in hospital as chest infection makes him miss charity event". The Times. Archived from the original on 21 May 2021. Retrieved 21 May 2021.
- ↑ Wright, Paul (2 August 2014). "Former lead physician to the Queen and Royal Free professor knighted". Hampstead Highgate Express. Retrieved 29 January 2022.
- ↑ Achieving therapeutic targets in the treatment of secondary hyperparathyroidism
- ↑ New Vitamin D analogs and changing therapeutic paradigms
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