Klaus Lauer

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Klaus Lauer (born 1950) is a German neuroepidemologist, mostly known for his work on multiple sclerosis (MS).

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Klaus Lauer DrKlausLauerGriesheim.png
Klaus Lauer

Early life

Klaus Joachim Lauer was born in 1950 and studied medicine in Frankfurt (Germany) from 1968 to 1975. He became a resident in the Department of Neurology of Klinikum Darmstadt, the Academic Teaching Hospital of Frankfurt University (Akademisches Lehrkrankenhaus der Universitäten Frankfurt/Main und Heidelberg-Mannheim, a major healthcare institution in South Hesse. Besides clinical work, Lauer devoted most of his research to epidemiology, with a special focus on MS etiology.

Career

Early on, he published a series of five articles [1] [2] [3] [4] [5] on multiple sclerosis in the land of Hesse with Wolfgang Firnhaber, who had already been studying MS epidemiology in Göttingen and Darmstadt, [6] with support from the Hertie Foundation, the German Research Foundation and the Stifterverband für die Deutsche Wissenschaft. His lasting collaboration with Prof. Firnhaber, a longtime expert in MS prognostication [7] [8] [9] and geomedical aspects of MS, [10] provided K. Lauer with a solid background in geomedical investigation. [11] [12]

In the mid 80's, Lauer launched a series of specialized reports in Scandinavia, starting with a study of multiple sclerosis in Western Norway published in Neurology. [13] He has been following Norvegian MS ever since [14] [15] and has also coauthored epidemiological studies in Sweden with Anne-Marie Landtblom and Inger Boström. [16]

Like John Kurtzke, [17] Klaus J. Lauer has dedicated a large part of his work to the study of MS in the Faroe Islands, [18] starting with a 1986 article in the Journal of Neurology entitled "Some comments on the occurrence of multiple sclerosis in the Faroe Islands", [19] followed in 1988 by "Multiple sclerosis in relation to industrial and commercial activities in the Faroe Islands" [20] in the journal Neuroepidemiology, followed one year later by "Dietary changes in temporal relation to multiple sclerosis in the Faroe Islands: an evaluation of literary sources" [21] in the same journal.

Remains of the WW2 British barracks at Vagar Airport on the Faroe Islands British barracks' remains at Vagar Airport, Faroe Islands.JPG
Remains of the WW2 British barracks at Vágar Airport on the Faroe Islands
2005 Faroese stamp: British soldiers and children in the Faroe Islands Faroe stamp 536 world war 2.jpg
2005 Faroese stamp: British soldiers and children in the Faroe Islands

MS is generally considered a multifactorial disease, [22] in which genetic predispositions and environmental triggers combine to launch an autoimmune process. As an international expert on the environmental dimension of MS, [23] Lauer compiled a review in Expert Review of Neurotherapeutics. [24]

Since 1992, Lauer has published a large number of epidemiological studies covering most west European countries, [25] [26] [27] [28] [29] Russia, [30] the USA, [31] [32] Canada, some countries in Asia and the Middle-East, [33] with a special focus on dietary aspects of etiology. [34] [35] [36] [37] Most recently, Klaus Lauer has focused again on MS in the Faroes [38] [39] and has been involved as an expert in the steering committee of the EnviMS study, a major multi-countries study investigating the impact of environmental exposures on MS. [40] [41] [42] Lauer is also one of the authors of a reference study of the cost of MS in Europe [43] and of several publications dealing with technical and methodological considerations in neuroepidemiology applied to multiple sclerosis. [44] [45]

References

  1. Lauer K, Firnhaber W, Reining R, Leuchtweis B (October 1984). "Epidemiological investigations into multiple sclerosis in southern Hesse. I. Methodological problems and basic epidemiologic characteristics". Acta Neurologica Scandinavica. 70 (4): 257–65. doi:10.1111/j.1600-0404.1984.tb00823.x. PMID   6507035. S2CID   37474492.
  2. Lauer K, Firnhaber W (October 1984). "Epidemiological investigations into multiple sclerosis in southern Hesse. II. The distribution of cases in relation to exogenous features". Acta Neurologica Scandinavica. 70 (4): 266–73. doi: 10.1111/j.1600-0404.1984.tb00824.x . PMID   6507036. S2CID   11874178.
  3. Lauer K, Firnhaber W (October 1985). "Epidemiological investigations into multiple sclerosis in Southern Hesse. III. The possible influence of occupation on the risk of disease". Acta Neurologica Scandinavica. 72 (4): 397–402. doi: 10.1111/j.1600-0404.1985.tb00890.x . PMID   4082904. S2CID   28427761.
  4. Lauer K, Firnhaber W (October 1985). "Epidemiological investigations into multiple sclerosis in Southern Hesse. IV. The influence of urban and rural environment on disease risk". Acta Neurologica Scandinavica. 72 (4): 403–6. doi: 10.1111/j.1600-0404.1985.tb00891.x . PMID   4082905. S2CID   36477076.
  5. Lauer K, Firnhaber W (July 1987). "Epidemiological investigations into multiple sclerosis in Southern Hesse. V. Course and prognosis". Acta Neurologica Scandinavica. 76 (1): 12–7. doi: 10.1111/j.1600-0404.1987.tb03537.x . PMID   3498287. S2CID   32088559.
  6. "Deutsches Ärzteblatt international: Multiple Sclerosis Registry in Germany – Results of the Extension Phase 2005/2006: Article of 30 Years Ago (25.04.2008)". Deutsches Ärzteblatt. Aerzteblatt.de. 2008-04-25. Retrieved 2015-04-01.
  7. Bauer HJ, Firnhaber W, Winkler W (March 1965). "Prognostic criteria in multiple sclerosis". Annals of the New York Academy of Sciences. 122 (1): 542–51. Bibcode:1965NYASA.122..542B. doi:10.1111/j.1749-6632.1965.tb20234.x. PMID   14313511. S2CID   31948757.
  8. Bauer H, Firnhaber W (July 1963). "Zur Leistungsprognose Multiple-Sklerose-Kranker" [On the prognosis of work capacity in patients with multiple sclerosis]. Deutsche Medizinische Wochenschrift (in German). 88 (27): 1357–64. doi:10.1055/s-0028-1112108. PMID   13966928.
  9. Lauer K, Firnhaber W (February 1992). "Prognostic criteria in an epidemiological group of patients with multiple sclerosis: an exploratory study". Journal of Neurology. 239 (2): 93–7. doi:10.1007/BF00862981. PMID   1552310. S2CID   24945652.
  10. Firnhaber W (May 1972). "[Multiple sclerosis. Methods and results of a geomedical study]". Fortschritte der Medizin (in German). 90 (14): 551–4. PMID   5072275.
  11. Poser S, Poser W, Schlaf G, et al. (November 1986). "Prognostic indicators in multiple sclerosis". Acta Neurologica Scandinavica. 74 (5): 387–92. doi:10.1111/j.1600-0404.1986.tb03531.x. PMID   3825497. S2CID   42211498.
  12. Prange AJ, Lauer K, Poser S, et al. (1986). "Epidemiological aspects of multiple sclerosis: a comparative study of four centres in Europe". Neuroepidemiology. 5 (2): 71–9. doi:10.1159/000110816. PMID   3785525.
  13. Lauer K, Firnhaber W (September 1985). "Western Norway: a high-risk area for MS". Neurology. 35 (9): 1392. doi:10.1212/wnl.35.9.1392. PMID   4022391. S2CID   41877517.
  14. Risberg G, Aarseth JH, Nyland H, Lauer K, Myhr KM, Midgard R (October 2011). "Prevalence and incidence of multiple sclerosis in Oppland County: a cross-sectional population-based study in a landlocked county of Eastern Norway". Acta Neurologica Scandinavica. 124 (4): 250–7. doi:10.1111/j.1600-0404.2010.01465.x. PMID   21143594. S2CID   22178018.
  15. Lauer K (February 2006). "Multiple sclerosis in Nordland County". Tidsskrift for den Norske Lægeforening. 126 (5): 637–8. PMID   16505886.
  16. Boström I, Landtblom AM, Lauer K (December 2011). "An ecological study of industry in a high-risk region of multiple sclerosis". Journal of the Neurological Sciences. 311 (1–2): 50–7. doi:10.1016/j.jns.2011.09.005. PMID   21982618. S2CID   9442941.
  17. "Multiple Sclerosis". Web.stanford.edu. 1997-03-21. Retrieved 2015-04-01.
  18. Klaus Lauer. "Dietary Changes in Temporal Relation to Multiple Sclerosis in the Faroe Islands : An Evaluation of Literary Sources" (PDF). While-science-sleeps.com. Retrieved 2015-04-01.
  19. Lauer K (June 1986). "Some comments on the occurrence of multiple sclerosis in the Faroe Islands". Journal of Neurology. 233 (3): 171–3. doi:10.1007/BF00314427. PMID   3522812. S2CID   22437259.
  20. Lauer K (1988). "Multiple sclerosis in relation to industrial and commercial activities in the Faroe Islands". Neuroepidemiology. 7 (4): 228–33. doi:10.1159/000110155. PMID   3264057.
  21. Lauer K (1989). "Dietary changes in temporal relation to multiple sclerosis in the Faroe Islands: an evaluation of literary sources". Neuroepidemiology. 8 (4): 200–6. doi:10.1159/000110183. PMID   2755551.
  22. Maxmen, Amy. "Whodunit? | Multiple Sclerosis Discovery Forum". Msdiscovery.org. Retrieved 2015-04-01.
  23. Lauer K (1995). "Environmental associations with the risk of multiple sclerosis: the contribution of ecological studies". Acta Neurologica Scandinavica. Supplementum. 161 (Suppl 161): 77–88. doi:10.1111/j.1600-0404.1995.tb05861.x. PMC   7159802 . PMID   7653250.
  24. Lauer K (March 2010). "Environmental risk factors in multiple sclerosis". Expert Review of Neurotherapeutics. 10 (3): 421–40. doi:10.1586/ern.10.7. PMID   20187864. S2CID   20219149.
  25. Lauer, K (1988). "Sociogeographic factors and multiple sclerosis--an ecological study in 6 European countries". Neuroepidemiology. 7 (3): 122–9. doi:10.1159/000110145. PMID   3405364.
  26. Lauer, K (1989). "Multiple sclerosis in relation to meat preservation in France and Switzerland". Neuroepidemiology. 8 (6): 308–15. doi:10.1159/000110199. PMID   2586701.
  27. Lauer, Klaus (1993-12-01). "A factor-analytical study of the multiple sclerosis mortality in Hesse and Baden-Wuerttemberg, Germany". Journal of Public Health. 1 (4): 319–327. doi:10.1007/BF02959681. S2CID   32460157.
  28. Lauer, K (1990). "Mortality of multiple sclerosis in relation to geographic factors in France". Neuroepidemiology. 9 (3): 113–7. doi:10.1159/000110759. PMID   2402320.
  29. Lauer, K (1989). "Risk of multiple sclerosis in relation to industrial activities: An ecological study in four European countries". Neuroepidemiology. 8 (1): 38–42. doi:10.1159/000110163. PMID   2911392.
  30. Gusev, E; Boiko, A; Lauer, K; Riise, T; Deomina, T (1996). "Environmental risk factors in MS: A case-control study in Moscow". Acta Neurologica Scandinavica. 94 (6): 386–94. doi: 10.1111/j.1600-0404.1996.tb00050.x . PMID   9017026. S2CID   20421779.
  31. Lauer, K (1994). "The risk of multiple sclerosis in the U.S.A. In relation to sociogeographic features: A factor-analytic study". Journal of Clinical Epidemiology. 47 (1): 43–8. doi:10.1016/0895-4356(94)90032-9. PMID   8283194.
  32. "Divergent risk of multiple sclerosis in two anabaptist communities in…". Archived from the original on 2014-08-04.
  33. Lauer, K; Alter, M.; Kahana, E.; Zilber, N.; Miller, A. (2007). "Multiple sclerosis frequency in Israel's diverse populations". Neurology. 68 (4): 311, author reply 311. doi:10.1212/01.wnl.0000255650.40828.98. PMID   17242346. S2CID   6452138.
  34. Lauer K (2014-11-12). "The food pattern in geographical relation to the risk of multiple sclerosis in the Mediterranean and Near East region". J Epidemiol Community Health. 45 (3): 251–2. doi:10.1136/jech.45.3.251. PMC   1060768 . PMID   1757770.
  35. Klaus Lauer (1997-08-01). "Diet and multiple sclerosis". Neurology. 49 (2 Suppl 2): S55 –S61. doi:10.1212/WNL.49.2_Suppl_2.S55. PMID   9270693. S2CID   5740619.
  36. Lauer, K (1991). "The history of nitrite in human nutrition: A contribution from German cookery books". Journal of Clinical Epidemiology. 44 (3): 261–4. doi:10.1016/0895-4356(91)90037-a. PMID   1999685.
  37. "Dr. Klaus Joachim Lauer Biography – Webcast powered by - MULTIWEBCAST - State-of-the-art Webcast Services". Multiwebcast.com. Retrieved 2015-04-01.
  38. Klaus Lauer (2011-06-13). "Multiple sclerosis incidence in the Faroe Islands". Multiple Sclerosis Journal. 17 (11): 1393–1394. doi:10.1177/1352458511408479. PMID   21669934. S2CID   39510239.
  39. Lauer, Klaus (2014). "IJMS | Free Full-Text | Notes on the Epidemiology of Multiple Sclerosis, with Special Reference to Dietary Habits". International Journal of Molecular Sciences. 15 (3): 3533–3545. doi: 10.3390/ijms15033533 . PMC   3975352 . PMID   24577315.
  40. Pugliatti, M.; Casetta, I.; Drulovic, J.; Granieri, E.; Holmøy, T.; Kampman, M. T.; Landtblom, A.-M.; Lauer, K.; Myhr, K.-M.; Parpinel, M.; Pekmezovic, T.; Riise, T.; Zhu, B.; Wolfson, C. (2012-12-20). "A questionnaire for multinational case-control studies of environmental risk factors in multiple sclerosis (EnvIMS-Q)". Acta Neurologica Scandinavica. 126 (195): 43–50. doi: 10.1111/ane.12032 . PMID   23278656. S2CID   29741160.
  41. Bjørnevik, Kjetil; Riise, Trond; Casetta, Ilaria; Drulovic, Jelena; Granieri, Enrico; Holmøy, Trygve; Kampman, Margitta T.; Landtblom, Anne-Marie; Lauer, Klaus; Lossius, Andreas; Magalhaes, Sandra; Myhr, Kjell-Morten; Pekmezovic, Tatjana; Wesnes, Kristin; Wolfson, Christina; Pugliatti, Maura (2014-01-10). "Sun exposure and multiple sclerosis risk in Norway and Italy: The EnvIMS study". Multiple Sclerosis Journal. 20 (8): 1042–1049. doi:10.1177/1352458513513968. PMID   24414538. S2CID   20910092.
  42. "Abstractverwaltung Congrex". Registration.akm.ch. 2013-10-03. Archived from the original on 2014-07-29. Retrieved 2015-04-01.
  43. Sobocki, P; Pugliatti, M; Lauer, K; Kobelt, G (2007). "Estimation of the cost of MS in Europe: Extrapolations from a multinational cost study". Multiple Sclerosis. 13 (8): 1054–64. doi:10.1177/1352458507077941. PMID   17623729. S2CID   3263445.
  44. Wolfson, C; Granieri, E; Lauer, K (1997). "Case-control studies in multiple sclerosis". Neurology. 49 (2 Suppl 2): S5–14. doi:10.1212/WNL.49.2_Suppl_2.S5. PMID   9270687. S2CID   31780484.
  45. Riise, T; Grønning, M; Fernández, O; Lauer, K; Midgard, R; Minderhoud, J. M.; Nyland, H; Pálffy, G; Poser, S; Aarli, J. A. (1992). "Early prognostic factors for disability in multiple sclerosis, a European multicenter study". Acta Neurologica Scandinavica. 85 (3): 212–8. doi: 10.1111/j.1600-0404.1992.tb04031.x . PMID   1575007. S2CID   44476.