Large dense core vesicles

Last updated July 14, 2025

Large dense core vesicle (LDCVs) are lipid vesicles in neurons and secretory cells which may be filled with neurotransmitters, such as catecholamines or neuropeptides. LDVCs release their content through SNARE-mediated exocytosis similar to synaptic vesicles.^[1] One key difference between synaptic vesicles and LDCVs is that protein synaptophysin which is present in the membrane of synaptic vesicles is absent in LDCVs.^[2] LDCVs have an electron dense core which appears as a black circle in micrographs obtained with transmission electron microscopy.^[1]

References

1 2 Edwards, Robert H (December 1998). "Neurotransmitter release: Variations on a theme". Current Biology. 8 (24): R883 –R885. Bibcode:1998CBio....8.R883E. doi:10.1016/s0960-9822(07)00551-9. ISSN 0960-9822. PMID 9843673.
↑ Winkler, H. (1997-08-01). "Membrane Composition of Adrenergic Large and Small Dense Core Vesicles and of Synaptic Vesicles: Consequences for Their Biogenesis" . Neurochemical Research. 22 (8): 921–932. doi:10.1023/A:1022410506476. ISSN 1573-6903. PMID 9239747.

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[:0-1] 1 2 Edwards, Robert H (December 1998). "Neurotransmitter release: Variations on a theme". Current Biology. 8 (24): R883 –R885. Bibcode:1998CBio....8.R883E. doi:10.1016/s0960-9822(07)00551-9. ISSN 0960-9822. PMID 9843673.

[2] Winkler, H. (1997-08-01). "Membrane Composition of Adrenergic Large and Small Dense Core Vesicles and of Synaptic Vesicles: Consequences for Their Biogenesis" . Neurochemical Research. 22 (8): 921–932. doi:10.1023/A:1022410506476. ISSN 1573-6903. PMID 9239747.

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