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Café au lait spots, or café au lait macules, are flat, hyperpigmented birthmarks. The name café au lait is French for "coffee with milk" and refers to their light-brown color. Café au lait lesions with rough borders may be seen in McCune-Albright syndrome. In contrast, café au lait lesions of neurofibromatosis have smooth borders.
A dysplastic nevus or atypical mole is a nevus (mole) whose appearance is different from that of common moles. In 1992, the NIH recommended that the term "dysplastic nevus" be avoided in favor of the term "atypical mole". An atypical mole may also be referred to as an atypical melanocytic nevus, atypical nevus, B-K mole, Clark's nevus, dysplastic melanocytic nevus, or nevus with architectural disorder.
A comedo is a clogged hair follicle (pore) in the skin. Keratin combines with oil to block the follicle. A comedo can be open (blackhead) or closed by skin (whitehead) and occur with or without acne. The word "comedo" comes from the Latin comedere, meaning "to eat up", and was historically used to describe parasitic worms; in modern medical terminology, it is used to suggest the worm-like appearance of the expressed material.
Dermatoscopy also known as dermoscopy or epiluminescence microscopy, is the examination of skin lesions with a dermatoscope. It is a tool similar to a camera to allow for inspection of skin lesions unobstructed by skin surface reflections. The dermatoscope consists of a magnifier, a light source, a transparent plate and sometimes a liquid medium between the instrument and the skin. Dermatoscope is often handheld, although there are stationary cameras allowing the capture of whole body images in a single shot. When the images or video clips are digitally captured or processed, the instrument can be referred to as a digital epiluminescence dermatoscope. The image is then analyzed automatically and given a score indicating how dangerous it is. This technique is useful to dermatologists and skin cancer practitioners in distinguishing benign from malignant (cancerous) lesions, especially in the diagnosis of melanoma.
Blaschko's lines, also called the lines of Blaschko, are lines of normal cell development in the skin. These lines are only visible in those with a mosaic skin condition or in chimeras where different cell lines contain different genes. These lines may express different amounts of melanin, or become visible due to a differing susceptibility to disease. In such individuals, they can become apparent as whorls, patches, streaks or lines in a linear or segmental distribution over the skin. They follow a V shape over the back, S-shaped whirls over the chest and sides, and wavy shapes on the head. Not all mosaic skin conditions follow Blascko's lines.
Degos disease, also known as Köhlmeier-Degos disease or malignant atrophic papulosis, is an extremely rare condition caused by blockage of arteries and veins. Individuals with this condition will develop papules. Those diagnosed with this disease may also develop complications due to impairment of internal organs. The exact underlying mechanism is still unknown, and an effective treatment is still being developed. There are fewer than 50 living patients presently known worldwide, and fewer than 200 reported in medical literature. However, many individuals may go undiagnosed due to rarity of the disease. Most individuals develop symptoms between the ages of 20–50; however, cases outside of this age range have been reported as well.
Ernest Henri Besnier was a French dermatologist and medical director of the Hôpital Saint-Louis in Paris. He was a native of Honfleur, département Calvados.
Joseph (Josef) Jadassohn was a German dermatologist.
Tetrazepam is a benzodiazepine derivative with anticonvulsant, anxiolytic, muscle relaxant and slightly hypnotic properties. It was formerly used mainly in Austria, France, Belgium, Germany and Spain to treat muscle spasm, anxiety disorders such as panic attacks, or more rarely to treat depression, premenstrual syndrome or agoraphobia. Tetrazepam has relatively little sedative effect at low doses while still producing useful muscle relaxation and anxiety relief. The Co-ordination Group for Mutual Recognition and Decentralised Procedures-Human endorsed the Pharmacovigilance Risk Assessment Committee (PRAC) recommendation to suspend the marketing authorisations of tetrazepam-containing medicines across the European Union (EU) in April 2013. The European Commission has confirmed the suspension of the marketing authorisations for Tetrazepam in Europe because of cutaneous toxicity, effective from the 1 August 2013.
Papillon–Lefèvre syndrome (PLS), also known as palmoplantar keratoderma with periodontitis, is an autosomal recessive genetic disorder caused by a deficiency in cathepsin C.
Henri Gougerot was a French dermatologist born in Saint-Ouen-sur-Seine. Gougerot is remembered for his work with numerous dermatological disorders.
Jean Baptiste Émile Vidal was a French dermatologist who was a native of Paris.
Aquagenic urticaria, also known as water allergy and water urticaria, is a rare form of physical urticaria in which hives develop on the skin after contact with water, regardless of its temperature. The condition typically results from contact with water of any type, temperature or additive.
Focal dermal hypoplasia is a form of ectodermal dysplasia. It is a multisystem disorder characterized primarily by skin manifestations to the atrophic and hypoplastic areas of skin which are present at birth. These defects manifest as yellow-pink bumps on the skin and pigmentation changes. The disorder is also associated with shortness of stature and some evidence suggests that it can cause epilepsy.
Schnitzler syndrome or Schnitzler's syndrome is a rare disease characterised by onset around middle age of chronic hives (urticaria) and periodic fever, bone pain and joint pain, weight loss, malaise, fatigue, swollen lymph glands and enlarged spleen and liver.
Schimmelpenning syndrome is a neurocutaneous condition characterized by one or more sebaceous nevi, usually appearing on the face or scalp, associated with anomalies of the central nervous system, ocular system, skeletal system, cardiovascular system and genitourinary system.
Marion Baldur Sulzberger was an American dermatologist known for major contributions in his discipline.
Rudiger syndrome is a congenital disorder characterized by the association of severe growth retardation with abnormalities of the extremities, urogenital abnormalities and facial abnormalities. It has been described in a family where an affected brother and sister died as infants. Both autosomal recessive and autosomal dominant inheritance have been suggested with the disorder.
Robert Degos (1904–1987) was a French dermatologist who described several dermatoses including Degos disease which he first described in a seminal paper published in 1942 in the French journal of dermatology and syphilology.
Lucien-Marie Pautrier was a French dermatologist.
References
- 1 2 A. Simon; B. Asli; M. Braun-Falco; H. De Koning; J.-P. Fermand; C. Grattan; K. Krause; H. Lachmann; C. Lenormand; V. Martinez-Taboada; M. Maurer; M. Peters; R. Rizzi; F. Rongioletti; T. Ruzicka; L. Schnitzler; B. Schubert; J. Sibilia; D. Lipsker (2013). Bieber, Thomas (ed.). "Schnitzler's syndrome: diagnosis, treatment, and follow-up". Allergy: European Journal of Allergy and Clinical Immunology. 68 (5): 562–568. doi:10.1111/all.12129. PMID 23480774. S2CID 12831354.
- ↑ Sanders, Lisa (2019). Diagnosis: Solving the Most Baffling Medical Mysteries. Crown. p. 16. ISBN 9780593136645.
- ↑ Sfriso, Paolo; Galozzi, Paola (2019). "15: The Schnitzler Syndrome". In Efthimiou, Petros (ed.). Auto-Inflammatory Syndromes: Pathophysiology, Diagnosis, and Management. Springer. p. 203.
- ↑ Griffiths, Christopher E.M.; Creamer, Daniel; Barker, Jonathan; Chalmers, Robert; Bleiker, Tanya O., eds. (February 2016). Rook's Textbook of Dermatology. Wiley. p. 45. ISBN 9781118441176.
- ↑ Baker, Charlotte; Cadogan, Mike (November 3, 2020). "Liliane Schnitzler". Life in the Fast Lane.
- ↑ Riaux, Anne (18 October 2006). Robert Degos (1904-1987), Sa Vie, Sa Ouvre (PDF) (doctorate) (in French). p. 31. Retrieved 9 January 2022.