List of immunofluorescence findings for autoimmune bullous conditions

Last updated

Several cutaneous conditions can be diagnosed with the aid of immunofluorescence studies.

Cutaneous conditions with positive direct or indirect immunofluorescence when using salt-split skin include:

Antibody isotype(s) and location of antibody deposition in immunofluorescence studies using salt-split skin for autoimmune bullous conditions targeting the basement membrane zone of the human integumentary system
ConditionAntibody isotype(s) depositedLocalization of antibody with use of salt-split skin
Antiepilegrin cicatricial pemphigoid IgGDermal
Bullous lupus erythematosus Dermal
Bullous pemphigoid IgG Epidermal
Cicatricial pemphigoid IgGEpidermal
Epidermolysis bullosa acquisita IgGDermal
Linear IgA bullous dermatosis IgA Epidermal
Orf-induced immunobullous disease IgGDermal
Pemphigoid gestationis IgGEpidermal

For several subtypes of pemphigus a variety of substrates are used for indirect immunofluorescence:

Substrates used in indirect immunofluorescence studies for the different pemphigus variants
Pemphigus variantSubstrate
Pemphigus foliaceous Guinea pig esophagus
Pemphigus vulgaris Monkey esophagus
IgA pemphigus Cultured skin
Paraneoplastic pemphigus Rat bladder

See also

Related Research Articles

Pemphigoid Autoimmune blistering diseases

Pemphigoid is a group of rare autoimmune blistering diseases of the skin, and mucous membranes. As its name indicates, pemphigoid is similar in general appearance to pemphigus, but, unlike pemphigus, pemphigoid does not feature acantholysis, a loss of connections between skin cells.

Epidermolysis bullosa acquisita (EBA) is a chronic subepidermal blistering disease associated with autoimmunity to type VII collagen within anchoring fibril structures that are located at the dermoepidermal junction.

Linear IgA bullous dermatosis Medical condition

Linear IgA bullous dermatosis is a rare immune-mediated blistering skin disease frequently associated with medication exposure, especially vancomycin, with men and women being equally affected. It was first described by Tadeusz Chorzelski in 1979 and may be divided into two types:

IgA pemphigus is a subtype of pemphigus with two distinct forms:

References