This is a list of the number-one hits of 2008 on FIMI's Italian Download and Albums Charts.
| Issue date | Song | Artist | Album | Artist |
|---|---|---|---|---|
| 4 January | "Baby Let's Play House" | Elvis Presley | All the Best | Zucchero |
| 11 January | GiannaBest | Gianna Nannini | ||
| 18 January | Safari | Jovanotti | ||
| 25 January | ||||
| 1 February | Beat ReGeneration | Pooh | ||
| 8 February | "Apologize" | Timbaland presents OneRepublic | ||
| 15 February | "Baby Let's Play House" | Elvis Presley | ||
| 22 February | "Apologize" | Timbaland presents OneRepublic | ||
| 29 February | "Estupido" | Cinema 2 | Safari | Jovanotti |
| 7 March | "Colpo di fulmine" | Giò Di Tonno and Lola Ponce | ||
| 14 March | "Il mondo che vorrei" | Vasco Rossi | ||
| 21 March | ||||
| 28 March | Il mondo che vorrei | Vasco Rossi | ||
| 4 April | "4 Minutes" | Madonna featuring Justin Timberlake and Timbaland | ||
| 11 April | "A te" | Jovanotti | ||
| 18 April | ||||
| 25 April | Hard Candy | Madonna | ||
| 2 May | ||||
| 9 May | ||||
| 16 May | Safari | Jovanotti | ||
| 23 May | Per brevità chiamato artista | Francesco De Gregori | ||
| 30 May | "Non ti scordar mai di me" | Giusy Ferreri | Secondo tempo | Ligabue |
| 6 June | ||||
| 13 June | "Cry..." | Novecento | Viva la Vida or Death and All His Friends | Coldplay |
| 20 June | ||||
| 27 June | "Everything" | Michael Bublé | Non ti scordar mai di me | Giusy Ferreri |
| 4 July | "Non ti scordar mai di me" | Giusy Ferreri | ||
| 11 July | ||||
| 18 July | ||||
| 25 July | ||||
| 1 August | ||||
| 8 August | ||||
| 15 August | ||||
| 22 August | ||||
| 29 August | ||||
| 5 September | ||||
| 12 September | Death Magnetic | Metallica | ||
| 19 September | "I Kissed a Girl" | Katy Perry | Psiche | Paolo Conte |
| 26 September | ||||
| 3 October | Dig Out Your Soul | Oasis | ||
| 10 October | "Alla Mia Età" | Tiziano Ferro | Musica moderna | Ivano Fossati |
| 17 October | "Novembre" | Giusy Ferreri | Black Ice | AC/DC |
| 24 October | Questo sono io | Gigi D'Alessio | ||
| 31 October | Il cielo ha una porta sola | Biagio Antonacci | ||
| 7 November | Alla Mia Età | Tiziano Ferro | ||
| 14 November | Primavera in anticipo | Laura Pausini | ||
| 21 November | ||||
| 28 November | ||||
| 5 December | ||||
| 12 December | ||||
| 19 December | ||||
| 26 December |