| Tenure | Incumbent | Notes |
|---|
| Agona |
| 1500 | Foundation of Agona state |
| Agonahenes (rulers) |
| 1588 to 1620 | Mumunumfi , Agonahene | Becoming Denkyirahene |
| Denkyira | State renamed |
| Denkyirahene (rulers) |
| 1620 to 1624 | Mumunumfi , Denkyirahene | Hitherto Agonahene |
| 1624 to 1637 | Werempe Ampem , Denkyirahene | |
| 1637 to 1695 | Boa Amponsem I , Denkyirahene | |
| 1695 to 1701 | Ntim Gyakari , Denkyirahene | |
| 1701 | Defeated by Asanteman, becoming tributary |
| 1701 to 1702 | Boado Ahafo Berempon , Denkyirahene | |
| 1702 to 1712 | Kyei Akobeng , Denkyirahene | |
| 1712 to 1720 | Amoako Atta Panyin , Denkyirahene | |
| 1720 to 1725 | Gyan Badu , Denkyirahene | |
| 1725 to 1770 | Amoako Atta Kuma , Denkyirahene | |
| 1770 to 1793 | Amoako Atta Yiadom , Denkyirahene | ♀ |
| 1793 to 1813 | Owusu Bori I , Denkyirahene | |
| 1813 to 1851 | Kwadwo Tibu I , Denkyirahene | |
| 1851 to 1859 | Kwakye Fram , Denkyirahene | |
| 1859 to 1869 | Kwesi Kyei I , Denkyirahene | |
| 1870 to 1875 | Boa Amponsem II , Denkyirahene | |
| 1875 to 1910 | Nkwantabisa I , Denkyirahene | |
| 1910 to 1912 | Kwesi Kyei II , Denkyirahene | |
| 1912 to 1918 | Nkwantabisa II , Denkyirahene | |
| 1919 to 1930 | Kwadwo Tibu II , Denkyirahene | |
| 1931 to 1941 | Nkwantabisa III , Denkyirahene | |
| 1942 to 1953 | Owusu Bori II , Denkyirahene | |
| ante/c.May 1954 to post/c. 1954 | Nana Kojo Odei , Regent | |
| 1955 to 2016 | Ɔdɛɛfoɔ Boa Amponsem III , Denkyirahene | |
| 2016 to 2025 | Vacant | Kingdom ruled by the Queen of Denkyira - Nana Ama Ayensua Saara III |
| 2025 to Present | Ɔdɛɛfoɔ Boa Amponsem IV , Denkyirahene | |
