| Rank | Name | Image | Height | Floors | Year | Notes |
|---|
| 01.01 | City Hall Plaza |  | 275 ft (84 m) | 22 | 1992 | The tallest building in New Hampshire since its completion in 1992, succeeding the Hampshire Plaza (now Brady Sullivan Plaza). The tallest building in New England north of Cambridge, Massachusetts. |
| 01.02 | Brady Sullivan Plaza |  | 259 ft (79 m) | 20 | 1972 | The tallest building in New Hampshire from 1972 until 1992. |
| 01.03 | Wall Street Apartments |  | 223 ft (68 m) | 18 | 1985 | Used to have a restaurant on the top floor. |
| 01.04 | WZID Tower | | 194 ft (59 m) | 5 | 1991 | 194-foot communications tower on top of the WZID Building. |
| 01.05 | Brady Sullivan Tower |  | 180 ft (55 m) | 18 | 1970 | Briefly was tallest building in New Hampshire. |
| 01.06 | Rev. Raymond A. Burns, OSB High Rise |  | 161 ft | 13 | 1980 | Residential. Tallest building on West Side. |
| 01.07 | DoubleTree by Hilton Manchester Downtown Hotel |  | 148 ft (45 m) | 12 | 1983 | Hotel and residential building |
| 01.08 | Carpenter Center |  | 148 ft (45 m) | 12 | 1923 | Once the biggest hotel in Manchester. |
| 01.09 | Citizens Bank Building |  | 131 ft (40 m) | 10 | 1913 | Known throughout 20th century as the Amoskeag Bank, it was referred to as the city's first "skyscraper". |
| 01.010 | Hampshire Tower | | 127 | 12 | 1973 | Condos |
| 01.011 | Henry J. Pariseau Building |  | 126 ft (38 m) | 11 | 1973 | Residential |
| 01.012 | 1155 Elm Street | | 121 ft (37 m) | 8 | 1986 | Office |
| 01.013 | Thomas B. O'Malley High Rise | | 112 ft (34 m) | 9 | 1969 | Residential |
| 01.013 | Christos Kalivas High Rise | | 112 ft (34 m) | 9 | 1972 | Residential |
| 01.013 | Residences at Manchester Place | | 112 ft (34 m) | 7 | 2005 | Residential |
| 01.016 | Elliot Hospital |  | 100 ft (30 m) | 8 | 1945 | ~300 beds |
| 01.017 | Center of New Hampshire |  | 92.5 ft (28.2 m) | 7 | 1985 | Attached to the DoubleTree hotel through the Center of NH Expo. |
| 01.018 | SNHU Arena |  | 92 ft (28 m) | 3 | 2001 | Hockey, concert and basketball arena. |
| 01.019 | Norris Cotton Federal Building | | 87 ft (27 m) | 7 | 1976 | |
| 01.019 | Governor Hugh J. Gallen Apartments | | 87 ft (27 m) | 7 | | |
| 01.019 | Catholic Medical Center |  | 87 ft (27 m) | 7 | 1978 | 300+ beds |
| 01.022 | VA Hospital | | 75 ft (23 m) | 6 | 1950 | |
| 01.022 | WMUR Building | | 75 ft (23 m) | 4 | 1987 | Headquarters for "New Hampshire's Number One News Team". |
