Louise McCullough

Last updated

Louise McCullough is an American neurologsit who is the Prof. Roy M. & Phyllis Gough Huffington Distinguished Chair of Neurology and is actively engaged in stroke research at the University of Texas Health Science Center in Houston, Texas (a.k.a. McGovern Medical School). She provides neurological care at Memorial Hermann Hospital, which has a state-of-the-art stroke center and is co-director of the Mischer Neuroscience Institute. [1]

Contents

Education

McCullough received an MD-PhD in neuroscience from the University of Connecticut. She continued her training as an intern and later neurology resident at Johns Hopkins University from 1996-2000, followed by a fellowship in cerebrovascular disease. [1] [2]

Career

McCullough began her career at Johns Hopkins School of Medicine, where she was an instructor and assistant professor in neurology. She relocated to UConn Health in 2004 and progressed to professor of neurology and neuroscience and director of stroke research at Hartford Hospital. [2] [3] She also received a Health Center Teaching and Faculty Award for excellence in teaching basic medical sciences. [4]

In 2015, McCullough moved to UT Health and later became the Prof. Roy M. & Phyllis Gough Huffington Distinguished Chair of Neurology. In 2018, McCullough was inducted into the Johns Hopkins Society of Scholars for excelling in her career since her training at the university. [5] McCullough also serves as the Program Chair of the International Stroke Conference. [6] [7] She also received the Javits Neuroscience Investigator Award from the National Institute of Neurological Disorders and Stroke in 2017 and the C. Miller Fisher, MD Neuroscience Visionary Award from the American Heart Association/American Stroke Association (AHA/ASA) in 2021. [1] [8] [9]

Research

McCullough’s research focuses on ischemic stroke. Because women tend to do worse than men in terms of survival and disability, she is studying the role that hormones play in stroke risk and recovery. [10] McCullough's work was instrumental in the development of the National Institutes of Health's requirement to include female animals in basic and translational studies. [5]

She recently received funding to apply her studies of sex differences towards improving understanding of COVID-19 outcomes. [11]

Related Research Articles

A transient ischemic attack (TIA), commonly known as a mini-stroke, is a minor stroke whose noticeable symptoms usually end in less than an hour. TIA causes the same symptoms associated with strokes, such as weakness or numbness on one side of the body, sudden dimming or loss of vision, difficulty speaking or understanding language, slurred speech, or confusion.

<span class="mw-page-title-main">National Institute of Neurological Disorders and Stroke</span> Department of the U.S. National Institutes of Health

The National Institute of Neurological Disorders and Stroke (NINDS) is a part of the U.S. National Institutes of Health (NIH). It conducts and funds research on brain and nervous system disorders and has a budget of just over US$2.03 billion. The mission of NINDS is "to reduce the burden of neurological disease—a burden borne by every age group, every segment of society, and people all over the world". NINDS has established two major branches for research: an extramural branch that funds studies outside the NIH, and an intramural branch that funds research inside the NIH. Most of NINDS' budget goes to fund extramural research. NINDS' basic science research focuses on studies of the fundamental biology of the brain and nervous system, genetics, neurodegeneration, learning and memory, motor control, brain repair, and synapses. NINDS also funds clinical research related to diseases and disorders of the brain and nervous system, e.g. AIDS, Alzheimer's disease, epilepsy, muscular dystrophy, multiple sclerosis, Parkinson's disease, spinal cord injury, stroke, and traumatic brain injury.

<span class="mw-page-title-main">Stroke</span> Death of a region of brain cells due to poor blood flow

A stroke is a medical condition in which poor blood flow to the brain causes cell death. There are two main types of stroke: ischemic, due to lack of blood flow, and hemorrhagic, due to bleeding. Both cause parts of the brain to stop functioning properly.

<span class="mw-page-title-main">Aptiganel</span> Chemical compound

Aptiganel is an unsuccessful drug candidate which acts as a noncompetitive NMDA antagonist, and that was under development by Cambridge Neuroscience, Inc as a treatment for stroke. It has neuroprotective effects and was researched for potential use in the treatment of stroke, but despite positive results in animal studies, human trials showed limited efficacy, as well as undesirable side effects such as sedation and hallucinations, and clinical development was ultimately not continued.

<span class="mw-page-title-main">Eve Marder</span> American neuroscientist

Eve Marder is a University Professor and the Victor and Gwendolyn Beinfield Professor of Neuroscience at Brandeis University. At Brandeis, Marder is also a member of the Volen National Center for Complex Systems. Dr. Marder is known for her pioneering work on small neuronal networks which her team has interrogated via a combination of complementary experimental and theoretical techniques.

<span class="mw-page-title-main">Wade Regehr</span>

Wade G. Regehr is a Professor of Neurobiology at Harvard Medical School's Department of Neurobiology.

<span class="mw-page-title-main">Anne B. Young</span> American neuroscientist

Anne Buckingham Young is an American physician and neuroscientist who has made major contributions to the study of neurodegenerative diseases, with a focus on movement disorders like Huntington's disease and Parkinson's disease. Young completed her undergraduate studies at Vassar College and earned a dual MD/PhD from Johns Hopkins Medical School. She has held faculty positions at University of Michigan and Harvard University. She became the first female chief of service at Massachusetts General Hospital when she was appointed Chief of Neurology in 1991. She retired from this role and from clinical service in 2012. She is a member of many academic societies and has won numerous awards. Young is also the only person to have been president of both the international Society for Neuroscience and the American Neurological Association.

<span class="mw-page-title-main">Huda Zoghbi</span> Lebanese scientist

Huda Yahya Zoghbi, born Huda El-Hibri, is a Lebanese-born American geneticist, and a professor at the Departments of Molecular and Human Genetics, Neuroscience and Neurology at the Baylor College of Medicine. She is the director of the Jan and Dan Duncan Neurological Research Institute. She became the editor of the Annual Review of Neuroscience as of 2018.

<span class="mw-page-title-main">Memorial Hermann–Texas Medical Center</span> Hospital in Texas, United States

Memorial Hermann–Texas Medical Center is a nationally ranked hospital at the Texas Medical Center. It is the first hospital founded in the Texas Medical Center in Houston, Texas. Founded in 1925, it is the primary teaching hospital for McGovern Medical School and the flagship location of 13 hospitals in the Memorial Hermann Healthcare System. It is one of three certified Level I Trauma Centers in the greater Houston area. The Memorial Hermann Life Flight air ambulance service operates its fleet of helicopters from Memorial Hermann–Texas Medical Center. Pediatric care to the hospital is provided by Children's Memorial Hermann Hospital which treats infants, children, teens, and young adults age 0-21.

Julie Bernhardt is an Australian physiotherapist and clinician scientist, a Principal Research Fellow and an NHMRC Senior Research Fellow and Clinical Head of the Stroke Division at the Florey Institute of Neuroscience and Mental Health, University of Melbourne. Bernhardt is Principal Investigator of the 'A Very Early Rehabilitation Trial' (AVERT) and a leader in the field of stroke recovery.

<span class="mw-page-title-main">Vladimir Hachinski</span> Canadian clinical neuroscientist

Vladimir Hachinski is a Canadian clinical neuroscientist and researcher based at the Schulich School of Medicine and Dentistry at Western University. He is also a Senior Scientist at London's Robarts Research Institute. His research pertains in the greatest part to stroke and dementia, the interactions between them and their joint prevention. He and John W. Norris helped to establish the world's first successful stroke unit at Sunnybrook Hospital in Toronto, and, by extension, helped cement stroke units as the standard of care for stroke patients everywhere. He discovered that the control of the heart by the brain is asymmetric, the fight/flight (sympathetic) response being controlled by the right hemisphere and the rest and digest (parasympathetic) response being controlled by the left hemisphere and damage to one key component can lead to heart irregularities and sudden death. This discovery has added fundamental knowledge to how the brain controls the heart and blood pressure and lays the foundation for helping prevent sudden death.

Kameshwar Prasad is an Indian neurologist, medical researcher, academic and the head of the department of Neurology at the All India Institute of Medical Sciences, Delhi (AIIMS), known as a proponent of Evidence-based medicine (EBM) and Evidence-based Healthcare (EBHC). The Government of India awarded him the fourth highest civilian honour of the Padma Shri in 1991.

<span class="mw-page-title-main">Amy Bastian</span> American neuroscientist (born 1968)

Amy Jo Bastian is an American neuroscientist, who has made important contributions to the neuroscience of sensorimotor control. From 2011 she has been a professor of neuroscience at Johns Hopkins University. In 2015 Bastian was appointed Chief Science Officer at the Kennedy Krieger Institute. Bastian is a member of the National Academy of Sciences.

<span class="mw-page-title-main">Odette Harris</span> American neurosurgeon

Odette Harris is a professor of neurosurgery at Stanford University and the Director of the Brain Injury Program for the Stanford University School of Medicine. She is the Deputy Chief of Staff, Rehabilitation at the VA Palo Alto Health Care System.

Maria G. Castro is the R. C. Schneider Collegiate Professor of Neurosurgery and a Professor of Cell and Developmental Biology at the University of Michigan Medical School. Her research focuses on cancer immunology and gliomas.

Ralph Lewis Sacco was an American neurologist. He held the Olemberg Family Chair in Neurological Disorders, Miller Professor of Neurology, Public Health Sciences, Human Genetics, and Neurosurgery at the Leonard M. Miller School of Medicine at the University of Miami and Chief of the Neurology Service at Jackson Memorial Hospital. In 2020, Sacco was named editor-in-chief of the Stroke journal and the inaugural recipient of the Edgar J. Kenton III Lecture Award from the American Stroke Association.

Lynda D. Lisabeth is an American epidemiologist who is Professor and Senior Associate Dean for Faculty Affairs in the School of Public Health at the University of Michigan. Her research considers the epidemiology of stroke in the United States, and she has worked with the National Institute of Neurological Disorders and Stroke on the advancement of stroke research.

David Alan McCormick is an American neurobiologist. He holds one of two Presidential chair positions and is director of the Institute of Neuroscience at the University of Oregon and co-director of the Neurons to Minds Cluster of Excellence.

Elizabeth Ann Jonas is an American physician and neuroscientist at the Yale School of Medicine where she is Professor of endocrinology and neuroscience. Her seminal work includes the first in vivo electrical recordings of mitochrondrial membrane potentials and influential research on metabolic pathways of neuronal death.

Opeolu Makanju Adeoye is an American physician who is the BJC HealthCare Distinguished Professor of Emergency Medicine and Department Chair at the Washington University School of Medicine. He was elected Fellow of the National Academy of Medicine in 2022.

References

  1. 1 2 3 "Visiting Professor Dr. Louise D. McCullough, MD, PhD". Department of Neurological Surgery. 606. Retrieved 2022-08-22.
  2. 1 2 "Averting the Devastating Effects of Stroke". UConn Today. 2013-05-30. Retrieved 2022-08-22.
  3. ↑ Averting the Devastating Effects of Stroke , retrieved 2022-08-22
  4. ↑ "Health Center Teaching and Faculty Award Winners Announced". UConn Today. 2012-05-07. Retrieved 2022-08-22.
  5. 1 2 "New members inducted into Johns Hopkins Society of Scholars". The Hub. 2018-04-10. Retrieved 2022-08-22.
  6. ↑ "Improving Patient Outcomes, Balancing Cost of Mobile Stroke Units with Louise McCullough, MD, PhD". Practical Cardiology. Retrieved 2022-08-22.
  7. ↑ "Science News 2022 - International Stroke Conference". professional.heart.org. Retrieved 2022-08-22.
  8. ↑ "McCullough honored with prestigious NIH Javits Award for stroke research". EurekAlert!. Retrieved 2022-08-22.
  9. ↑ "McCullough wins AHA/ASA Neuroscience Visionary Award". John P. and Kathrine G. McGovern Medical School at UTHealth. 2021-09-27. Retrieved 2022-08-22.
  10. ↑ McCullough LD, Zeng Z, Blizzard KK, Debchoudhury I, Hurn PD (2005). "Ischemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: male toxicity, female protection". J. Cereb. Blood Flow Metab. 25 (4): 502–12. doi: 10.1038/sj.jcbfm.9600059 . PMID   15689952.
  11. ↑ "McCullough and Liu awarded $3.7M NIH grant to study sex differences in COVID-19 outcomes". EurekAlert!. Retrieved 2021-11-16.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.