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Rinderpest was an infectious viral disease of cattle, domestic buffalo, and many other species of even-toed ungulates, including gaurs, buffaloes, large antelope, deer, giraffes, wildebeests, and warthogs. The disease was characterized by fever, oral erosions, diarrhea, lymphoid necrosis, and high mortality. Death rates during outbreaks were usually extremely high, approaching 100% in immunologically naïve populations. Rinderpest was mainly transmitted by direct contact and by drinking contaminated water, although it could also be transmitted by air.
Cyclosporiasis is a disease caused by infection with Cyclospora cayetanensis, a pathogenic apicomplexan protozoan transmitted by feces or feces-contaminated food and water. Outbreaks have been reported due to contaminated fruits and vegetables. It is not spread from person to person, but can be a hazard for travelers as a cause of diarrhea.
The global spread of H5N1 influenza in birds is considered a significant pandemic threat. While other H5N1 influenza strains are known, they are significantly different on a genetic level from a recent, highly pathogenic, emergent strain of H5N1, which was able to achieve hitherto unprecedented global spread in 2008. The H5N1 strain is a fast-mutating, highly pathogenic avian influenza virus (HPAI) found in multiple bird species. It is both epizootic and panzootic. Unless otherwise indicated, "H5N1" in this timeline refers to the recent highly pathogenic strain of H5N1.
Simplexvirus bovinealpha2, also known as Bovine alphaherpesvirus 2 (BoHV2) is a virus of the family Herpesviridae. It causes two diseases in cattle, bovine mammillitis and pseudo-lumpy skin disease.
Lumpy skin disease (LSD) is an infectious disease in cattle caused by a virus of the family Poxviridae, also known as Neethling virus. The disease is characterized by fever, enlarged superficial lymph nodes, and multiple nodules on the skin and mucous membranes, including those of the respiratory and gastrointestinal tracts. Infected cattle may also develop edematous swelling in their limbs and exhibit lameness. The virus has important economic implications since affected animals tend to have permanent damage to their skin, lowering the commercial value of their hide. Additionally, the disease often results in chronic debility, reduced milk production, poor growth, infertility, abortion, and sometimes death.
Globalization, the flow of information, goods, capital, and people across political and geographic boundaries, allows infectious diseases to rapidly spread around the world, while also allowing the alleviation of factors such as hunger and poverty, which are key determinants of global health. The spread of diseases across wide geographic scales has increased through history. Early diseases that spread from Asia to Europe were bubonic plague, influenza of various types, and similar infectious diseases.
Mass psychogenic illness (MPI), also called mass sociogenic illness, mass psychogenic disorder, epidemic hysteria or mass hysteria, involves the spread of illness symptoms through a population where there is no infectious agent responsible for contagion. It is the rapid spread of illness signs and symptoms affecting members of a cohesive group, originating from a nervous system disturbance involving excitation, loss, or alteration of function, whereby physical complaints that are exhibited unconsciously have no corresponding organic causes that are known.
Bovine spongiform encephalopathy (BSE), commonly known as mad cow disease, is an incurable and invariably fatal neurodegenerative disease of cattle. Symptoms include abnormal behavior, trouble walking, and weight loss. Later in the course of the disease, the cow becomes unable to function normally. There is conflicting information about the time between infection and onset of symptoms. In 2002, the World Health Organization (WHO) suggested it to be approximately four to five years. Time from onset of symptoms to death is generally weeks to months. Spread to humans is believed to result in variant Creutzfeldt–Jakob disease (vCJD). As of 2018, a total of 231 cases of vCJD had been reported globally.
Foot-and-mouth disease (FMD) or hoof-and-mouth disease (HMD) is an infectious and sometimes fatal viral disease that affects cloven-hoofed animals, including domestic and wild bovids. The virus causes a high fever lasting two to six days, followed by blisters inside the mouth and near the hoof that may rupture and cause lameness.
The 1889–1890 pandemic, often referred to as the "Asiatic flu" or "Russian flu", was a worldwide respiratory viral pandemic. It was the last great pandemic of the 19th century, and is among the deadliest pandemics in history. The pandemic killed about 1 million people out of a world population of about 1.5 billion. The most reported effects of the pandemic took place from October 1889 to December 1890, with recurrences in March to June 1891, November 1891 to June 1892, the northern winter of 1893–1894, and early 1895.
Capripoxvirus is a genus of viruses in the subfamily Chordopoxvirinae and the family Poxviridae. Capripoxviruses are among the most serious of all animal poxviruses. All CaPV are notifiable diseases to the OIE. Sheep, goat, and cattle serve as natural hosts. These viruses cause negative economic consequences by damaging hides and wool and forcing the establishment of trade restrictions in response to an outbreak. The genus consists of three species: sheeppox virus (SPPV), goatpox virus (GTPV), and lumpy skin disease virus (LSDV). They share no serological relationship with camel pox, horse pox, or avian poxes. Capripoxviruses for sheeppox and goatpox infect only sheep and goat respectively. However, it is probable that North American relatives, the mountain goat and mountain sheep, may be susceptible to the strains but has not been experimentally proven. Lumpy skin disease virus affects primarily cattle, but studies have been shown that giraffes and impala are also susceptible to LSDV. Humans cannot be infected by Capripoxviruses.
Actinomyces bovis is a branching, Gram-positive, rod-shaped bacterium of the genus Actinomyces. It is the causative agent of lumpy jaw in cattle, and occasionally causes actinomycosis infections in humans. A. bovis normally populates the gastrointestinal tract of healthy ruminants, but is opportunistic in nature and will move into tissues through ulcerations or abrasions of the mucosa to cause infection. The disease occurs when there is physical damage to the tissue of the mouth, allowing the bacteria to colonize the deep tissue and bone, typically affecting the mandible and maxilla. Actinomycosis is pathognomonic for abscesses containing "sulfur" granules, and its colonies appear basophilic with club-shaped reaction products on a histological preparation. Lumpy jaw is commonly treated with broad-spectrum antibiotics with varying success, and can be a major economic loss for producers in countries where it is endemic. Because this organism is zoonotic, it is a human health concern and can cause granulomas, abscesses, skin lesions, and bronchopneumonia.
The United Kingdom was afflicted with an outbreak of Bovine spongiform encephalopathy, and its human equivalent variant Creutzfeldt–Jakob disease (vCJD), in the 1980s and 1990s. Over four million head of cattle were slaughtered in an effort to contain the outbreak, and 178 people died after contracting vCJD through eating infected beef. A political and public health crisis resulted, and British beef was banned from export to numerous countries around the world, with some bans remaining in place until as late as 2019.
Events in the year 2020 in Nepal.
The COVID-19 pandemic in Nepal is part of the worldwide pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2. The first case in Nepal was confirmed on 23 January 2020 when a 31-year-old student, who had returned to Kathmandu from Wuhan on 9 January, tested positive for the disease. It was also the first recorded case of COVID-19 in South Asia. Nepal's first case of local transmission was confirmed on 4 April in Kailali District. The first death occurred on 14 May. A country-wide lockdown came into effect on 24 March 2020, and ended on 21 July 2020. As of 26 July 2022, the Ministry of Health and Population (MoHP) has confirmed a total of 984,475 cases, 968,802 recoveries, and 11,959 deaths in the country. In the meantime, 5,804,358 real-time RT-PCR (RT-qPCR) tests have been performed in 40 laboratories across the country. The viral disease has been detected in all provinces and districts of the country, with Bagmati Province and Kathmandu being the worst hit province and district respectively. As for Nepalese abroad, as of 26 July 2020, the Non-Resident Nepali Association has reported a total of 12,667 confirmed cases, 16,190 recoveries, and 161 deaths across 35 countries.
Lumpy skin disease was spotted in Pakistan in Jamshoro district, Sindh in November 2021. By 9 September 2022, over 7000 cattle had died. Pakistan has 93 million cattle and buffaloes.
The 2022 lumpy skin disease outbreak in India resulted in the death of over 97,000 cattle in three months between July and 23 September. Starting from outbreaks in Gujarat and Rajasthan, in three months cattle in 15 states across India were affected. On 21 September, out of 18,50,000 cases over 65% of cases were from Rajasthan. Over 50,000 deaths were reported from Rajasthan. India's cattle population according to the last livestock census was 192.5 million.
Lumpi-ProVacInd is a live attenuated vaccine for cattle, made by two institutes of Indian Council of Agricultural Research for prevention of Lumpy skin disease outbreak in India. It is planned for commercial launch in early 2023. It was launched by Prime Minister Narendra Modi and Agriculture Minister Narendra Singh Tomar. Studies concluded that it is 100 percent effective for the prevention of the disease, which complies with all government vaccine standards. It is similar to the vaccines for tuberculosis and rubella.
References
- ↑ Koirala, Pragya; Meki, Irene Kasindi; Maharjan, Manju; Settypalli, Bharani Kumar; Manandhar, Salina; Yadav, Sanjay Kumar; Cattoli, Giovanni; Lamien, Charles Euloge (2022-02-28). "Molecular Characterization of the 2020 Outbreak of Lumpy Skin Disease in Nepal". Microorganisms. 10 (3): 539. doi: 10.3390/microorganisms10030539 . ISSN 2076-2607. PMC 8954389 . PMID 35336114.
- ↑ "Lumpy Skin Disease" (PDF), Technical Bulletin, vol. 1, no. 1, Central Veterinary Laboratory (CVL), Tripureshwar, Kathmandu, retrieved 2024-04-13
- ↑ "Lumpy skin disease kills 48,133 cattle". kathmandupost.com. Retrieved 2024-04-13.
- ↑ "Nepal Development Update". World Bank. Retrieved 2024-04-13.