A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer. When this gene mutates to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with other genetic changes. The loss of these genes may be even more important than proto-oncogene/oncogene activation for the formation of many kinds of human cancer cells. Tumor suppressor genes can be grouped into categories including caretaker genes, gatekeeper genes, and landscaper genes; the classification schemes are evolving as medicine advances, learning from fields including molecular biology, genetics, and epigenetics.
BRCA2 and BRCA2 are a human gene and its protein product, respectively. The official symbol and the official name are maintained by the HUGO Gene Nomenclature Committee. One alternative symbol, FANCD1, recognizes its association with the FANC protein complex. Orthologs, styled Brca2 and Brca2, are common in other vertebrate species. BRCA2 is a human tumor suppressor gene, found in all humans; its protein, also called by the synonym breast cancer type 2 susceptibility protein, is responsible for repairing DNA.
Roxana Moslehi is an Iranian genetic epidemiologist.
Prostaglandin-I synthase also known as prostaglandin I2 (prostacyclin) synthase (PTGIS) or CYP8A1 is an enzyme involved in prostanoid biosynthesis that in humans is encoded by the PTGIS gene. This enzyme belongs to the family of cytochrome P450 isomerases.
Glutathione S-transferase P is an enzyme that in humans is encoded by the GSTP1 gene.
Multidrug resistance-associated protein 1 (MRP1) is a protein that in humans is encoded by the ABCC1 gene.
Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 is an enzyme that in humans is encoded by the ALK gene.
Natural resistance-associated macrophage protein 1 is a protein that in humans is encoded by the SLC11A1 gene.
Glutathione S-transferase M3 (brain), also known as GSTM3, is an enzyme which in humans is encoded by the GSTM3 gene.
L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene.
Myosin-XVIIIb is a protein that in humans is encoded by the MYO18B gene.
Thymocyte selection-associated high mobility group box protein TOX is a protein that in humans is encoded by the TOX gene.
TOX high mobility group box family member 3, also known as TOX3, is a human gene.
Zinc transporter 1 is a protein which in humans is encoded by the SLC30A1 gene.
CYP2A7 is a protein that in humans is encoded by the CYP2A7 gene.
Sir Michael Rudolf Stratton, is a British clinical scientist and the third director of the Wellcome Trust Sanger Institute. He currently heads the Cancer Genome Project and is a leader of the International Cancer Genome Consortium.
Glutathione peroxidase 3 (GPx-3), also known as plasma glutathione peroxidase (GPx-P) or extracellular glutathione peroxidase is an enzyme that in humans is encoded by the GPX3 gene.
A gene is said to be polymorphic if more than one allele occupies that gene’s locus within a population. In addition to having more than one allele at a specific locus, each allele must also occur in the population at a rate of at least 1% to generally be considered polymorphic.
Lung cancer susceptibility tests suggest the probability or susceptibility an individual may have of getting lung cancer. Lung cancer is a disease characterized by uncontrolled cell growth in the lung tissue. If left untreated, this growth can spread beyond the lungs in a process called metastasis, into nearby tissues or other parts of the body.
Lung cancer susceptibility 5 is a protein that in humans is encoded by the LNCR5 gene.
