METRNL

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Meteorin-like/Meteorin-Beta (Metrnl)/IL-41, also known as subfatin and cometin, is a small (~27kDa) secreted cytokine, protein encoded by a gene called meteorin-like (METRNL). [1]

Lower serum levels of Metrnl might be a risk factor for developing coronary artery disease and type 2 diabetes mellitus [2] [3]

References

  1. ↑ Rao RR, Long JZ, White JP, et al. (2015). "Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis". Cell. 157 (6): 1279–1291. doi:10.1016/j.cell.2014.03.065. PMC   4131287 . PMID   24906147.
  2. ↑ Dadmanesh M, Aghajani H, Fadaei R, Ghorban K (2018) Lower serum levels of Meteorin-like/Subfatin in patients with coronary artery disease and type 2 diabetes mellitus are negatively associated with insulin resistance and inflammatory cytokines. PLoS ONE 13(9): e0204180. PMID   30212581 PMC   6136801 Lock-green.svg doi : 10.1371/journal.pone.0204180
  3. ↑ Liu, Z. X., Ji, H. H., Yao, M. P., Wang, L., Wang, Y., Zhou, P., ... & Gao, W. (2019). Serum Metrnl is associated with the presence and severity of coronary artery disease. Journal of cellular and molecular medicine, 23(1), 271-280. doi : 10.1111/jcmm.13915 PMC   6307872 Lock-green.svg PMID   30394666
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