Margaret Hotchkiss | |
---|---|
Alma mater | Yale University |
Scientific career | |
Institutions | University of Kentucky |
Thesis | The influence of various salts upon the growth of bacterium communities (1922) |
Margaret Hotchkiss was a distinguished professor at the University of Kentucky. She is a microbiologist known for her work on bacteria in seawater and sewage, and fungi that cause disease. In 1957, she was elected a fellow of the American Academy of Microbiology.
Hotchkiss grew up in Brooklyn, New York, and graduated from Packer Collegiate Institute and Vassar College. [1] In 1922, Hotchkiss earned a Ph.D. from Yale University. [2] Hotchkiss worked at New York Medical College for seventeen years. [1] [3] She also worked at Woods Hole Oceanographic Institution as a visiting researcher, and was a bacteriologist at the New Jersey Agricultural Experiment Station, and the Department of Health in Paterson, New Jersey. [3] In 1945 Hotchkiss joined the faculty at the University of Kentucky, [3] where she was promoted to associate professor in 1946. [4] She later became the head of the mycology department at the University of Kentucky, [5] and was named a distinguished professor in 1962. [1] [6] Hotchkiss also served as the head of Sigma Xi, [1] [6] and the head of the Kentucky-Tennessee branch of the Society of American Bacteriologists. [7] [8] In 1964, Hotchkiss retired from teaching but continued conducting research. [9] [10]
For her Ph.D., Hotchkiss investigated the positive and negative effects of cations on bacterial growth. [11] She then worked with Selman Waksman to assess whether bacteria in sea water could grow [12] and differences in data obtained from visual examination of bacteria compared to growth of bacteria on agar plates. [13] Her marine research included investigations into the nitrogen cycle mediated by bacteria in seawater, [14] and in 1946 she continued her interest in seawater bacteria when she reviewed Claude ZoBell's Marine Microbiology book. [15] Her subsequent research examined hexosidases in Escherichia coli, [16] and the bacterial community in Imhoff tanks [17] that are used for processing sewage. [18] Having become interested in fungi that cause disease while working in New York, [8] she later published on the bacteria found in the human mouth, [19] and biomedical research on histoplasmosis [20] and Nocardia. [21] After retiring from teaching, she focused on using a precision microtome to slice through bacterial cells [8] and investigated the internal structure of bacteria. [22] [23]
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: CS1 maint: DOI inactive as of November 2024 (link)In 1957, Hotchkiss was elected a charter fellow of the American Academy of Microbiology. [24] In 1959, she was named to Who's Who to honor her contribution to education. [25] The University of Kentucky named her as the 1962-1963 distinguished professor. [26] She was elected a fellow of the New York Academy of Sciences. [9] [ when? ]
Selman Abraham Waksman was a Jewish American inventor, Nobel Prize laureate, biochemist and microbiologist whose research into the decomposition of organisms that live in soil enabled the discovery of streptomycin and several other antibiotics. A professor of biochemistry and microbiology at Rutgers University for four decades, he discovered several antibiotics, and he introduced procedures that have led to the development of many others. The proceeds earned from the licensing of his patents funded a foundation for microbiological research, which established the Waksman Institute of Microbiology located at the Rutgers University Busch Campus in Piscataway, New Jersey (USA). In 1952, he was awarded the Nobel Prize in Physiology or Medicine for "ingenious, systematic, and successful studies of the soil microbes that led to the discovery of streptomycin." Waksman and his foundation later were sued by Albert Schatz, one of his Ph.D. students and the discoverer of streptomycin, for minimizing Schatz's role in the discovery.
Stanley "Stan" Falkow was an American microbiologist and a professor of microbiology at Georgetown University, University of Washington, and Stanford University School of Medicine. Falkow is known as the father of the field of molecular microbial pathogenesis. He formulated molecular Koch's postulates, which have guided the study of the microbial determinants of infectious diseases since the late 1980s. Falkow spent over 50 years uncovering molecular mechanisms of how bacteria cause disease and how to disarm them. Falkow also was one of the first scientists to investigate antimicrobial resistance, and presented his research extensively to scientific, government, and lay audiences explaining the spread of resistance from one organism to another, now known as horizontal gene transfer, and the implications of this phenomenon on our ability to combat infections in the future.
Thermus thermophilus is a Gram-negative bacterium used in a range of biotechnological applications, including as a model organism for genetic manipulation, structural genomics, and systems biology. The bacterium is extremely thermophilic, with an optimal growth temperature of about 65 °C (149 °F). Thermus thermophilus was originally isolated from a thermal vent within a hot spring in Izu, Japan by Tairo Oshima and Kazutomo Imahori. The organism has also been found to be important in the degradation of organic materials in the thermogenic phase of composting. T. thermophilus is classified into several strains, of which HB8 and HB27 are the most commonly used in laboratory environments. Genome analyses of these strains were independently completed in 2004. Thermus also displays the highest frequencies of natural transformation known to date.
Myxococcus xanthus is a gram-negative, bacillus species of myxobacteria that is typically found in the top-most layer of soil. These bacteria lack flagella; rather, they use pili for motility. M. xanthus is well-known for its predatory behavior on other microorganisms. These bacteria source carbon from lipids rather than sugars. They exhibit various forms of self-organizing behavior in response to environmental cues. Under normal conditions with abundant food, they exist as predatory, saprophytic single-species biofilm called a swarm, highlighting the importance of intercellular communication for these bacteria. Under starvation conditions, they undergo a multicellular development cycle.
Swarming motility is a rapid and coordinated translocation of a bacterial population across solid or semi-solid surfaces, and is an example of bacterial multicellularity and swarm behaviour. Swarming motility was first reported by Jorgen Henrichsen and has been mostly studied in genus Serratia, Salmonella, Aeromonas, Bacillus, Yersinia, Pseudomonas, Proteus, Vibrio and Escherichia.
Roberto Kolter is Professor of Microbiology, Emeritus at Harvard Medical School, an author, and past president of the American Society for Microbiology. Kolter has been a professor at Harvard Medical School since 1983 and was Co-director of Harvard's Microbial Sciences Initiative from 2003-2018. During the 35-year term of the Kolter laboratory from 1983 to 2018, more than 130 graduate students and postdoctoral trainees explored an eclectic mix of topics gravitating around the study of microbes. Kolter is a fellow of the American Association for the Advancement of Science and of the American Academy of Microbiology.
Thauera aromatica is a species of bacteria. Its type strain is K 172T.
Azoarcus evansii is a species of bacteria. Its type strain is KB 740T.
Roseovarius nubinhibens is a species of Gram-negative, rod-shaped, aerobic dimethylsulfoniopropionate-demethylating bacteria. Its type strain is ISMT.
Methylophaga marina is an obligately methylotrophic, Gram-negative, strictly aerobic, motile, rod-shaped bacteria, the type species of its genus. Its type strain is ATCC 35842.
Methylophaga thalassica is an obligately methylotrophic, Gram-negative, strictly aerobic, motile, rod-shaped bacteria. Its type strain is ATCC 33146.
Streptomyces antibioticus is a gram-positive bacterium discovered in 1941 by Nobel-prize-winner Selman Waksman and H. Boyd Woodruff. Its name is derived from the Greek "strepto-" meaning "twisted", alluding to this genus' chain-like spore production, and "antibioticus", referring to this species' extensive antibiotic production. Upon its first characterization, it was noted that S. antibioticus produces a distinct soil odor.
The Brachyspira holin (B-Hol) Family consists of several proteins from the GTA holin of Brachyspira hyodysenteriae, which facilitates gene transfer agent-release to VSH-1 holin of Brachyspira pilosicoli. VSH-1 is thought to participate in cell lysis. These proteins range in size from about 85 to 145 amino acyl residues (aas) and exhibit between 2 and 4 transmembrane segments (TMSs). A representative list of proteins belonging to the B-Hol family can be found in the Transporter Classification Database.
R bodies are polymeric protein inclusions formed inside the cytoplasm of bacteria. Initially discovered in kappa particles, bacterial endosymbionts of the ciliate Paramecium, R bodies have since been discovered in a variety of taxa.
Elizabeth Bugie Gregory was an American biochemist who co-discovered Streptomycin, the first antibiotic against Mycobacterium tuberculosis in Selman Waksman laboratory at Rutgers University. Waksman went on to win the Nobel Prize for Medicine in 1952 and took the credit for the discovery.
In bacteriology, minicells are bacterial cells that are smaller than usual. The first minicells reported were from a strain of Escherichia coli that had a mutation in the Min System that lead to mis-localization of the septum during cell division and the production of cells of random sizes.
Catherine Louise Kearney Squires was a microbiologist known for her work on ribosomal RNA using Escherichia coli as a model organism. She was an elected fellow of the American Academy of Microbiology and the American Association for the Advancement of Science.
Virginia L. Miller is a microbiologist known for her work on studying the factors leading to disease caused by bacteria. Miller is an elected fellow of the American Academy of Microbiology (2003) and a former Pew Charitable Trust Biomedical Scholar (1989).
Robert Lyman Starkey was an American microbiologist. He was the president of the American Society for Microbiology in 1963.
Richard P. Novick is an American microbiologist best known for his work in the fields of plasmid biology, staphylococcal pathobiology and antimicrobial resistance. He is the Recanati Family Professor of Science, Emeritus, at NYU Grossman School of Medicine and is a member of the American National Academy of Sciences. Novick has published over 250 peer-reviewed articles, and several book reviews for the Times Literary Supplement, and is a member of the Editorial Board of the Proceedings of the National Academy of Sciences.
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