Mark T. Wallace

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Mark Wallace, Ph.D WallaceM 2015.jpg
Mark Wallace, Ph.D

Mark Wallace (born 1959) is an American neuroscientist currently holding the Louise B. McGavock Chair of Neuroscience at Vanderbilt University.

Contents

Biography

Wallace graduated in biology from Temple University in 1985, where he also completed a master's degree in biology and a Ph.D. in Neurobiology in 1990. [1] He was also a post-doctoral fellow at the Medical College of Virginia from 1990 to 1993.

Wallace was Director of the Vanderbilt Brain Institute from 2008 to 2021. Wallace was an assistant professor in the department of physiology at the Medical College of Virginia for a year before moving to Wake Forest University School of Medicine where he was assistant professor from 1994 to 2002 and associate professor from 2002 to 2005.

Wallace joined the faculty at Vanderbilt University in 2006 where he has held positions in the departments of Hearing and Speech Sciences, Psychology and Pharmacology. Wallace was dean of the Graduate School at Vanderbilt University from 2015 to 2020. [2] Wallace is an elected Fellow of the American Association for the Advancement of Science (2017) [3] and of the Association for Psychological Science (2018).

Wallace heads the Multisensory Research Lab which studies the neural bases of multisensory processing. [4] He is a member of the Vanderbilt Kennedy Center. [5]

Research

Wallace is an expert on multisensory integration using animal behavior, [6] neurophysiological recordings from single neurons and ensembles of neurons, neuroanatomical tract tracing, human psychophysics and fMRI. [7]

In studies in the rat, Wallace discovered that neurons located between sensory-specific areas (e.g., only visual or auditory) responded to inputs from several modalities (e.g., both visual and auditory). [8] [9] His most cited work (521 citations as in June 2023) has demonstrated that older adults benefit more than younger ones from redundant information across multiple sensory channels (e.g., vision and audition).

His research on visual perception in Autism was featured in Scientific American. [10] Wallace has co-authored books on multi-sensory integration.

Selected publications

Related Research Articles

<span class="mw-page-title-main">Sensory nervous system</span> Part of the nervous system responsible for processing sensory information

The sensory nervous system is a part of the nervous system responsible for processing sensory information. A sensory system consists of sensory neurons, neural pathways, and parts of the brain involved in sensory perception and interoception. Commonly recognized sensory systems are those for vision, hearing, touch, taste, smell, balance and visceral sensation. Sense organs are transducers that convert data from the outer physical world to the realm of the mind where people interpret the information, creating their perception of the world around them.

<span class="mw-page-title-main">Parietal lobe</span> Part of the brain responsible for sensory input and some language processing

The parietal lobe is one of the four major lobes of the cerebral cortex in the brain of mammals. The parietal lobe is positioned above the temporal lobe and behind the frontal lobe and central sulcus.

Multisensory integration, also known as multimodal integration, is the study of how information from the different sensory modalities may be integrated by the nervous system. A coherent representation of objects combining modalities enables animals to have meaningful perceptual experiences. Indeed, multisensory integration is central to adaptive behavior because it allows animals to perceive a world of coherent perceptual entities. Multisensory integration also deals with how different sensory modalities interact with one another and alter each other's processing.

Sensory processing is the process that organizes and distinguishes sensation from one's own body and the environment, thus making it possible to use the body effectively within the environment. Specifically, it deals with how the brain processes multiple sensory modality inputs, such as proprioception, vision, auditory system, tactile, olfactory, vestibular system, interoception, and taste into usable functional outputs.

Sensory neuroscience is a subfield of neuroscience which explores the anatomy and physiology of neurons that are part of sensory systems such as vision, hearing, and olfaction. Neurons in sensory regions of the brain respond to stimuli by firing one or more nerve impulses following stimulus presentation. How is information about the outside world encoded by the rate, timing, and pattern of action potentials? This so-called neural code is currently poorly understood and sensory neuroscience plays an important role in the attempt to decipher it. Looking at early sensory processing is advantageous since brain regions that are "higher up" contain neurons which encode more abstract representations. However, the hope is that there are unifying principles which govern how the brain encodes and processes information. Studying sensory systems is an important stepping stone in our understanding of brain function in general.

Eric Knudsen is a professor of neurobiology at Stanford University. He is best known for his discovery, along with Masakazu Konishi, of a brain map of sound location in two dimensions in the barn owl, tyto alba. His work has contributed to the understanding of information processing in the auditory system of the barn owl, the plasticity of the auditory space map in developing and adult barn owls, the influence of auditory and visual experience on the space map, and more recently, mechanisms of attention and learning. He is a recipient of the Lashley Award, the Gruber Prize in Neuroscience, and the Newcomb Cleveland prize and is a member of the National Academy of Sciences.

Mriganka Sur is the Newton Professor of Neuroscience and Director of the Simons Center for the Social Brain at the Massachusetts Institute of Technology. He is also a Visiting Faculty Member in the Department of Computer Science and Engineering at the Indian Institute of Technology Madras and N.R. Narayana Murthy Distinguished Chair in Computational Brain Research at the Centre for Computational Brain Research, IIT Madras. He was on the Life Sciences jury for the Infosys Prize in 2010 and has been serving as Jury Chair from 2018.


Sensory integration therapy (SIT) was originally developed by occupational therapist A. Jean Ayres in the 1970s to help children with sensory-processing difficulties. It was specifically designed to treat Sensory Processing Disorder. Sensory Integration Therapy is based on A. Jean Ayres's Sensory Integration Theory, which proposes that sensory-processing is linked to emotional regulation, learning, behavior, and participation in daily life. Sensory integration is the process of organizing sensations from the body and from environmental stimuli.

Barry E. Stein the Chairman of the Department of Neurobiology & Anatomy at the Wake Forest University School of Medicine, where he is also Professor of Neurology. He is also director of the joint Cognitive Neuroscience PhD Program between Wake Forest University and the University of Bologna in Italy.

Sensory-motor coupling is the coupling or integration of the sensory system and motor system. Sensorimotor integration is not a static process. For a given stimulus, there is no one single motor command. "Neural responses at almost every stage of a sensorimotor pathway are modified at short and long timescales by biophysical and synaptic processes, recurrent and feedback connections, and learning, as well as many other internal and external variables".

Andreas Karl Engel is a German neuroscientist. He is the director of the Department of Neurophysiology and Pathophysiology at the University Medical Center Hamburg-Eppendorf (UKE).

<span class="mw-page-title-main">Sensory processing disorder</span> Medical condition

Sensory processing disorder is a condition in which multisensory input is not adequately processed in order to provide appropriate responses to the demands of the environment. Sensory processing disorder is present in many people with dyspraxia, autism spectrum disorder and attention deficit hyperactivity disorder. Individuals with SPD may inadequately process visual, auditory, olfactory (smell), gustatory (taste), tactile (touch), vestibular (balance), proprioception, and interoception sensory stimuli.

<span class="mw-page-title-main">Mark Bear</span> American neuroscientist

Mark Firman Bear is an American neuroscientist. He is currently the Picower Professor of Neuroscience at The Picower Institute for Learning and Memory at Massachusetts Institute of Technology. He is a former Howard Hughes Medical Institute Investigator; an Elected Fellow of the American Association for the Advancement of Science and the American Academy of Arts and Sciences; and a Member of the National Academy of Medicine.

Multisensory learning is the assumption that individuals learn better if they are taught using more than one sense (modality). The senses usually employed in multisensory learning are visual, auditory, kinesthetic, and tactile – VAKT. Other senses might include smell, taste and balance.

Anne K. Churchland is a neuroscientist at University of California, Los Angeles. Her laboratory studies the function of the posterior parietal cortex in cognitive processes such as decision-making and multisensory integration. One of her discoveries is that individual neurons in rodent posterior parietal cortex can multitask i.e. play a role in multiple behaviors. Another discovery is that rodents are similar to humans in their ability to perform multisensory integration, i.e. to integrate stimuli from two different modalities such as vision and hearing.

Anna Wang Roe is an American neuroscientist, the director of the Interdisciplinary Institute of Neuroscience and Technology (ZIINT), and full-time professor at the Zhejiang University, Hangzhou, China. She is known for her studies on the functional organization and connectivity of cerebral cortex and for bringing interdisciplinary approaches to address questions in systems neuroscience.

HollisT. Cline is an American neuroscientist and the Director of the Dorris Neuroscience Center at the Scripps Research Institute in California. Her research focuses on the impact of sensory experience on brain development and plasticity.

<span class="mw-page-title-main">Laura Busse</span> German neuroscientist

Laura Busse is a German neuroscientist and professor of Systemic Neuroscience within the Division of Neurobiology at the Ludwig Maximilian University of Munich. Busse's lab studies context-dependent visual processing in mouse models by performing large scale in vivo electrophysiological recordings in the thalamic and cortical circuits of awake and behaving mice.

<span class="mw-page-title-main">John Foxe (neuroscientist)</span> Irish neuroscientist

John J. Foxe is an English-born Irish neuroscientist, who is the Kilian J. and Caroline F. Schmitt Chair in Neuroscience at the University of Rochester in New York, where he is Professor and Chair of the Department of Neuroscience. He is a visiting professor at The Albert Einstein College of Medicine in New York, Trinity College Dublin, City University of New York, and the National University of Ireland at Maynooth. He is the editor-in-chief of the European Journal of Neuroscience.

<span class="mw-page-title-main">Sophie Molholm</span> American neuroscientist

Sophie Molholm is an American neuroscientist, who is the director of the Cognitive Neurophysiology Laboratory (CNL) and the Human Clinical Phenotyping Core (HCP) at the Albert Einstein College of Medicine in New York. She is professor (tenured) of Paediatrics, Neuroscience and Psychiatry, and Behavioral Sciences, and was endowed as the Muriel and Harold Block Faculty Scholar in Mental Illness at Einstein (2012–2017).

References

  1. "SFARI | Mark Wallace". 2021-10-26. Archived from the original on 2021-10-26. Retrieved 2023-08-07.
  2. "Mark Wallace named dean of the Graduate School". Vanderbilt University.
  3. Snyder, Bill. "15 faculty members elected as AAAS fellows". Vanderbilt University.
  4. "Wallace Lab Members". Vanderbilt Kennedy Center.
  5. "Mark Wallace, Ph.D." Vanderbilt Kennedy Center.
  6. "Expert lectures on multisensory integration". USC News. 23 January 2012.
  7. "Turning Heads: The Vanderbilt Brain Institute has emerged as a hub of discovery as neuroscience's influence expands". Vanderbilt University.
  8. Calvert, G; Spence, C; Stein, BE (2004). The handbook of multisensory processes. MIT press. ISBN   9780262033213.
  9. Ghazanfar, AA; Schroeder, CE (2006). "s neocortex essentially multisensory?". Trends in Cognitive Sciences. 10 (6): 278–285. doi:10.1016/j.tics.2006.04.008. PMID   16713325. S2CID   2218969.
  10. Katsnelson,Spectrum, Alla. "Visual Task May Offer a Brain Marker for Autism". Scientific American.