Rotavirus is a genus of double-stranded RNA viruses in the family Reoviridae. Rotaviruses are the most common cause of diarrhoeal disease among infants and young children. Nearly every child in the world is infected with a rotavirus at least once by the age of five. Immunity develops with each infection, so subsequent infections are less severe. Adults are rarely affected. There are nine species of the genus, referred to as A, B, C, D, F, G, H, I and J. Rotavirus A, the most common species, causes more than 90% of rotavirus infections in humans.
Reoviridae is a family of double-stranded RNA viruses. Member viruses have a wide host range, including vertebrates, invertebrates, plants, protists and fungi. They lack lipid envelopes and package their segmented genome within multi-layered capsids. Lack of a lipid envelope has allowed three-dimensional structures of these large complex viruses to be obtained, revealing a structural and likely evolutionary relationship to the cystovirus family of bacteriophage. There are currently 97 species in this family, divided among 15 genera in two subfamilies. Reoviruses can affect the gastrointestinal system and respiratory tract. The name "reo-" is an acronym for "respiratory enteric orphan" viruses. The term "orphan virus" refers to the fact that some of these viruses have been observed not associated with any known disease. Even though viruses in the family Reoviridae have more recently been identified with various diseases, the original name is still used.
An enterotoxin is a protein exotoxin released by a microorganism that targets the intestines.
Thomas Henry Flewett, MD, FRCPath, FRCP was a founder member of the Royal College of Pathologists and was elected a Fellow of the Royal College of Physicians of London in 1978. He was chairman of the World Health Organization (WHO) Steering Committee on Viral Diarrhoeal Diseases, 1990–3, and a member until 1996. His laboratory in Birmingham was a World Health Organization Reference and Research Centre for Rotavirus Infections from 1980 until his retirement in 1987. He was an external examiner, visiting lecturer, and scientific journal editor. He was a member of the board of the Public Health Laboratory Service from 1977 to 1983 and was Chairman of the Public Health Laboratory Service's Committee on Electron Microscopy from 1977 to 1987.
An attenuated vaccine is a vaccine created by reducing the virulence of a pathogen, but still keeping it viable. Attenuation takes an infectious agent and alters it so that it becomes harmless or less virulent. These vaccines contrast to those produced by "killing" the virus.
Susana López Charretón is a Mexican virologist specialized in understanding the mechanisms of infection of rotavirus. López Charretón has led a research program as principal investigator at the Biotechnology Institute (UNAM) in Cuernavaca, Mexico for over 25 years.
Ruth Frances Bishop was an Australian virologist, who was a leading member of the team that discovered the human rotavirus.
Peter Jay Hotez is an American scientist, pediatrician, and advocate in the fields of global health, vaccinology, and neglected tropical disease control. He serves as founding dean of the National School of Tropical Medicine, Professor of Pediatrics and Molecular Virology & Microbiology at Baylor College of Medicine, where he is also Director of the Texas Children's Hospital Center for Vaccine Development and Texas Children's Hospital Endowed Chair in Tropical Pediatrics, and University Professor of Biology at Baylor College of Medicine. Hotez served previously as president of the American Society of Tropical Medicine and Hygiene and is a founding Editor-in-Chief of PLOS Neglected Tropical Diseases. He is also the co-director of Parasites Without Borders, a global nonprofit organization with a focus on those suffering from parasitic diseases in subtropical environments.
Rotavirus gastroenteritis is a major cause of severe diarrhoea among infants and young children globally. It is caused by rotavirus, a genus of double-stranded RNA virus in the family Reoviridae. The diarrhea tends to be watery and is frequently accompanied by fever, vomiting and abdominal pain. By the age of five, nearly every child in the world has been infected with rotavirus at least once. However, with each infection, immunity develops, and subsequent infections are less severe; adults are rarely affected. There are five species of this virus, referred to as A, B, C, D, and E. Rotavirus A, the most common, causes more than 90% of infections in humans.
Thumbi Ndung’u is a Kenyan-born HIV/AIDS researcher. He is the deputy director (Science) and a Max Planck Research Group Leader at the Africa Health Research Institute (AHRI) in Durban, South Africa. He is Professor of Infectious Diseases in the Division of Immunity and Infection, University College London. He is Professor and Victor Daitz Chair in HIV/TB Research and Scientific Director of the HIV Pathogenesis Programme (HPP) at the Nelson R. Mandela School of Medicine, University of KwaZulu-Natal. He holds the South African Research Chair in Systems Biology of HIV/AIDS. He is an Adjunct Professor of Immunology and Infectious Diseases at the Harvard T.H. Chan School of Public Health. He is the Programme Director of the Sub-Saharan African Network for TB/HIV Research Excellence (SANTHE), a research and capacity building initiative funded by the African Academy of Sciences and the Wellcome Trust.
José Esparza is a Venezuelan American virologist who lives in the USA. He is known for his efforts to promote the international development and testing of vaccines against HIV/AIDS. During 17 years he pursued an academic career at the Venezuelan Institute for Scientific Research (IVIC), attaining positions as full professor of virology and chairman of its Department of Microbiology and Cell Biology. From 1986 to 2014 he worked continuously as a viral vaccine expert and senior public health adviser for international health policy agencies such as the World Health Organization, the Joint United Nations Programme on HIV/AIDS, and the Bill & Melinda Gates Foundation. José G. Esparza is currently an adjunct professor of medicine, at the Institute of Human Virology. During 2016 he was the President of the Global Virus Network. In the context of historical studies on the early use of horsepox for smallpox vaccination, Esparza was appointed in 2018 as a Robert Koch Fellow at the Robert Koch Institute in Berlin, Germany. He is an active member of the Latin American Academy of Sciences, ACAL.
A. Oveta Fuller is an associate professor of microbiology and immunology at University of Michigan Medical School. She currently serves as the director of the African Studies Center (ASC), faculty in the ASC STEM Initiative at the University of Michigan (U-M) and an adjunct professor at Payne Theological Seminary. Fuller is a virologist and specializes in research of Herpes simplex virus, as well as HIV/AIDS. Fuller and her research team discovered a B5 receptor, advancing the understanding of Herpes simplex virus and the cells it attacks.
Janet S Butel is the Chairman and Distinguished Service Professor in the molecular virology and microbiology department at Baylor College of Medicine. Her area of expertise is on polyomavirus pathogenesis of infections and disease. She has more than 120 publications on PubMed. She also has 6 publications in Nature, which is considered one of the most prestigious science journals. She is a member of 9 different organizations and has 13 honors and awards.
Julius S. Youngner was an American Distinguished Service Professor in the School of Medicine and Department of Microbiology & Molecular Genetics at University of Pittsburgh responsible for advances necessary for development of a vaccine for poliomyelitis and the first intranasal equine influenza vaccine.
Gagandeep Kang FRS is an Indian Microbiologist and virologist who is the Professor in the Department of Gastrointestinal Sciences at the Christian Medical College, Vellore, India and from August 2016 to July 2020 was executive director of the Translational Health Science and Technology Institute, Faridabad, an autonomous institute of the Department of Biotechnology, Ministry of Science and Technology, Government of India. She is a leading researcher with a major research focus on viral infections in children, and the testing of rotaviral vaccines. She also works on other enteric infections and their consequences when children are infected in early life, sanitation and water safety. She was awarded the prestigious Infosys Prize in Life Sciences in 2016 for her contributions to understanding the natural history of rotavirus and other infectious diseases. In 2019, she became the first Indian woman to be elected as a Fellow of the Royal Society. She was on the Life Sciences jury for the Infosys Prize in 2020.
Gary J. Nabel is an American virologist and immunologist, and President and chief executive officer of ModeX Therapeutics in Natick, Massachusetts.
Carol Shoshkes Reiss, an American viral immunologist, has been professor in New York University's department of biology since 1991. Her research focused on the dynamic contest between the mouse immune system and virus replication during infection of the central nervous system. Reiss was editor-in-chief of the journal Viral Immunology (2000–2006) and is currently editor-in-chief of the journal DNA and Cell Biology (2012–present).
Karen Louise Mossman is a Canadian virologist who is a professor of Pathology and Molecular Medicine at McMaster University. Mossman looks to understand how viruses get around the defence mechanisms of cells. She was part of a team of Canadian researchers who first isolated SARS-CoV-2.
Herbert "Bert" Lancashire DuPont is an American physician, medical school professor, and medical researcher, specializing in infectious diseases.
