Mary M. Horowitz | |
|---|---|
| Born | Brooklyn, New York, US |
| Academic background | |
| Education | MS, 1991, MD, Medical College of Wisconsin |
| Thesis | Comparison of chemotherapy and bone marrow transplantation for adults with acute lymphoblastic leukemia in first remission (1991) |
| Academic work | |
| Institutions | Medical College of Wisconsin |
Mary M. Horowitz is an American oncologist who specializes in blood and marrow transplants.
Horowitz was born to Irish-Italian parents in Brooklyn,New York. As the oldest of seven children,she was discouraged from attending college by her father. [1] Despite this,she enrolled at the Medical College of Wisconsin for her Master's degree and medical degree. Horowitz remained at the institution for her residency in internal medicine and fellowship in hematology and oncology. [2] Prior to beginning medical school,Horowitz gave birth to her first child. [1]
Following her formal education,Horowitz joined the International Bone Marrow Transplant Registry in 1985 and began serving as its Chief Scientific Director in 1991. [3] [4] While serving in this role,she was also appointed Research Director for the Stem Cell Therapeutic Outcomes Database of the C.W. Bill Young Cell Transplantation Program and Principal Investigator of the Data and Coordinating Center of the National Blood and Marrow Transplant Clinical Trials Network. [5] As a result of her mentorships,Horowitz was the recipient of the 2010 ASH Mentor Award in recognition of the "significant impact they have made in the training and career development of many physicians and scientists in the field of hematology." [6] Horowitz continued to study the effectiveness of transplantation as a treatment for life-threatening diseases and was recognized by the American Society for Blood and Marrow Transplantation with the 2014 Lifetime Achievement Award. [5]
In 2019,Horowitz earned recognition from the American College of Physicians and Aplastic Anemia &MDS International Foundation. During the summer of 2019,she received the 2019 Harriet P. Dustan Award for Science as Related to Medicine from the American College of Physicians. [7] Later,Horowitz was honored by the Aplastic Anemia &MDS International Foundation "for the significant impact her work has had on stem cell transplant and hematologic malignancy practice worldwide." [8]
In 2006,Horowitz was diagnosed with stage IIB breast cancer. [9]
A myelodysplastic syndrome (MDS) is one of a group of cancers in which immature blood cells in the bone marrow do not mature,and as a result,do not develop into healthy blood cells. Early on,no symptoms typically are seen. Later,symptoms may include feeling tired,shortness of breath,bleeding disorders,anemia,or frequent infections. Some types may develop into acute myeloid leukemia.
Aplastic anemia is a disease in which the body fails to produce blood cells in sufficient numbers. Blood cells are produced in the bone marrow by stem cells that reside there. Aplastic anemia causes a deficiency of all blood cell types:red blood cells,white blood cells,and platelets.
Fanconi anaemia (FA) is a rare genetic disease resulting in impaired response to DNA damage. Although it is a very rare disorder,study of this and other bone marrow failure syndromes has improved scientific understanding of the mechanisms of normal bone marrow function and development of cancer. Among those affected,the majority develop cancer,most often acute myelogenous leukemia (AML),and 90% develop aplastic anemia by age 40. About 60–75% have congenital defects,commonly short stature,abnormalities of the skin,arms,head,eyes,kidneys,and ears,and developmental disabilities. Around 75% have some form of endocrine problem,with varying degrees of severity.
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare,acquired,life-threatening disease of the blood characterized by destruction of red blood cells by the complement system,a part of the body's innate immune system. This destructive process occurs due to deficiency of the red blood cell surface protein DAF,which normally inhibits such immune reactions. Since the complement cascade attacks the red blood cells within the blood vessels of the circulatory system,the red blood cell destruction (hemolysis) is considered an intravascular hemolytic anemia. Other key features of the disease,such as the high incidence of venous blood clot formation,are incompletely understood.
Edward Donnall "Don" Thomas was an American physician,professor emeritus at the University of Washington,and director emeritus of the clinical research division at the Fred Hutchinson Cancer Research Center. In 1990 he shared the Nobel Prize in Physiology or Medicine with Joseph E. Murray for the development of cell and organ transplantation. Thomas and his wife and research partner Dottie Thomas developed bone marrow transplantation as a treatment for leukemia.
Pancytopenia is a medical condition in which there is significant reduction in the number of almost all blood cells.
Sideroblastic anemia,or sideroachrestic anemia,is a form of anemia in which the bone marrow produces ringed sideroblasts rather than healthy red blood cells (erythrocytes). In sideroblastic anemia,the body has iron available but cannot incorporate it into hemoglobin,which red blood cells need in order to transport oxygen efficiently. The disorder may be caused either by a genetic disorder or indirectly as part of myelodysplastic syndrome,which can develop into hematological malignancies.
Robert Peter Gale is an American physician and medical researcher. He is known for research in leukemia and other bone marrow disorders.
Normocytic anemia is a type of anemia and is a common issue that occurs for men and women typically over 85 years old. Its prevalence increases with age,reaching 44 percent in men older than 85 years. The most common type of normocytic anemia is anemia of chronic disease.
Bone marrow failure occurs in individuals who produce an insufficient amount of red blood cells,white blood cells or platelets. Red blood cells transport oxygen to be distributed throughout the body's tissue. White blood cells fight off infections that enter the body. Bone marrow also contains platelets,which trigger clotting,and thus help stop the blood flow when a wound occurs.
Neal Stuart Young is an American physician and researcher,chief of the Hematology Branch of the National Institutes of Health (NIH),and Director of the Center for Human Immunology at the NIH in Bethesda,Maryland. He is primarily known for work in the pathophysiology and treatment of aplastic anemia,and is also known for his contributions to the pathophysiology of parvovirus B19 infection.
King Fahad Specialist Hospital-Dammam (KFSHD) is a hospital in the Eastern region of Saudi Arabia.
Guo Mei is a hematologist and associate director of 307th Hospital of Chinese People’s Liberation Army and deputy director of Radiation Research Institute.
Refractory cytopenia of childhood is a subgroup of myelodysplastic syndrome (MDS),having been added to the World Health Organization classification in 2008. Before then,RCC cases were classified as childhood aplastic anemia. RCC is the most common form of MDS in children and adolescents,accounting for approximately half of all MDS cases.
Carl H. June is an American immunologist and oncologist. He is currently the Richard W. Vague Professor in Immunotherapy in the Department of Pathology and Laboratory Medicine at the Perelman School of Medicine of the University of Pennsylvania. He is most well known for his research into T cell therapies for the treatment of cancer. In 2020 he was elected to the American Philosophical Society.
Surapol Issaragrisil is medical doctor and professor of medicine at Division of Hematology,Department of Medicine,Faculty of Medicine Siriraj Hospital,Mahidol University. He is an expert at hematology,bone marrow transplantation,and blood stem cells transplantation.
Dr. Mammen Chandy is the Director of Tata Medical Center,Kolkata. Chandy,an alumnus of the Christian Medical College Vellore,is a pioneer in the field of bone marrow transplantation in India. He was involved in setting up the first sustained bone marrow transplantation programme in the country,in Christian Medical College,Vellore in 1986. In January 2019,Chandy was awarded Padma Shri for his contribution in the field of medicine.
Stephanie J. Lee is an American haematologist and physician scientist who is Professor and Associate Director at the Fred Hutchinson Cancer Research Center. Lee works to improve the lives of blood stem cell transplant and bone marrow patients by better understanding the chronic form of graft-versus-host disease. Lee is the former President of the American Society of Hematology.
Julie Ann Panepinto is an American pediatric hematologist-oncologist and physician-scientist. She specializes in health outcomes research and sickle cell disease. Panepinto became the acting director of the division of blood diseases and resources at the National Heart,Lung,and Blood Institute in 2022. She was a professor of pediatrics and hematology at the Medical College of Wisconsin.
