McQuaid is a surname of Irish origin, from the County Monaghan and other surrounding areas in Ulster. It originated as a variation of McCaul, and similar spellings include McQuade and McQuaide. Notable people with the surname include:
Kieron McQuaid (born 1950), former Irish cyclist
Mart McQuaid (1861–1928), professional baseball player
Matt McQuaid (born 1996), American professional basketball player
Melanie McQuaid (born 1973), Canadian triathlete
Melvin McQuaid (1911–2001), Canadian politician
Michelle McQuaid (born 1991), Canadian curler
Oliver McQuaid (born 1954), Irish former cyclist
Paddy McQuaid, Irish road racing cyclist
Pat McQuaid (born 1949), Irish racing cyclist
Paul McQuaid, Irish cyclist
Peter McQuaid, Canadian politician
Phyllis W. McQuaid (1928–2023), American politician
Sarah McQuaid (born 1966), Spanish-born British singer, songwriter and guitarist
Tommy McQuaid (1936–1981), Irish footballer
Ululani McQuaid (1890–1970), Hawaiian opera singer and civic leader