Michael B. Elowitz is a biologist and professor of Biology, Bioengineering, and Applied Physics at the California Institute of Technology,[1][2][3] and investigator at the Howard Hughes Medical Institute.[4] In 2007 he was the recipient of the Genius grant, better known as the MacArthur Fellows Program for the design of a synthetic gene regulatory network, the Repressilator, which helped initiate the field of synthetic biology.[5] He was the first to show how inherently random effects, or 'noise', in gene expression could be detected and quantified in living cells,[6] leading to a growing recognition of the many roles that noise plays in living cells. His work in Synthetic Biology and Noise represent two foundations of the field of Systems Biology. Since then, his laboratory has contributed to the development of synthetic biological circuits that perform a range of functions inside cells, and revealed biological circuit design principles underlying epigenetic memory, cell fate control, cell-cell communication, and multicellular behaviors.[7]
His laboratory studies the dynamics of genetic circuits in individual living cells using synthetic biology, time-lapse microscopy, and mathematical modeling, with a particular focus on the way in which cells make use of noise to implement behaviors that would be difficult or impossible without it. Recently, his lab has expanded their approaches beyond bacteria to include eukaryotic and mammalian cells.[8]
Bintu L, Yong J, Antebi YE, McCue K, Kazuki Y, Uno N, Oshimura M, Elowitz MB, "Dynamics of epigenetic regulation at the single-cell level," Science (2016).[23]
Lin Y, Sohn CH, Dalal CK, Cai L, Elowitz MB, Combinatorial gene regulation by modulation of relative pulse timing, Nature, 2015[24]
Rosenfeld, N.; Elowitz, M. B.; Alon, U. (2002). "Negative autoregulation speeds the response times of transcription networks". Journal of Molecular Biology. 323 (5): 785–793. doi:10.1016/S0022-2836(02)00994-4. PMID12417193.
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